Search Results - "Creek, J J"

Efficient Hydrate Plug Prevention by Creek, J. L

“…A primary focus of flow assurance engineers during project development is the prevention and management of gas hydrate formation in pipelines. Historically,…”
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Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins by Klonis, Nectarios, Creek, Darren J, Tilley, Leann

“…Graphical abstract…”
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Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments by Srivastava, Anubhav, Philip, Nisha, Hughes, Katie R, Georgiou, Konstantina, MacRae, James I, Barrett, Michael P, Creek, Darren J, McConville, Malcolm J, Waters, Andrew P

“…Malaria parasites (Plasmodium spp.) encounter markedly different (nutritional) environments during their complex life cycles in the mosquito and human hosts…”
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Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics by Dunn, Warwick B., Erban, Alexander, Weber, Ralf J. M., Creek, Darren J., Brown, Marie, Breitling, Rainer, Hankemeier, Thomas, Goodacre, Royston, Neumann, Steffen, Kopka, Joachim, Viant, Mark R.

“…Metabolomics has advanced significantly in the past 10 years with important developments related to hardware, software and methodologies and an increasing…”
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Simultaneous electrical recording of cardiac electrophysiology and contraction on chip by Qian, Fang, Huang, Chao, Lin, Yi-Dong, Ivanovskaya, Anna N, O'Hara, Thomas J, Booth, Ross H, Creek, Cameron J, Enright, Heather A, Soscia, David A, Belle, Anna M, Liao, Ronglih, Lightstone, Felice C, Kulp, Kristen S, Wheeler, Elizabeth K

“…Prevailing commercialized cardiac platforms for in vitro drug development utilize planar microelectrode arrays to map action potentials, or impedance sensing…”
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Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution by Yap, Yann W., Rusu, Patricia M., Chan, Andrea Y., Fam, Barbara C., Jungmann, Andreas, Solon-Biet, Samantha M., Barlow, Christopher K., Creek, Darren J., Huang, Cheng, Schittenhelm, Ralf B., Morgan, Bruce, Schmoll, Dieter, Kiens, Bente, Piper, Matthew D. W., Heikenwälder, Mathias, Simpson, Stephen J., Bröer, Stefan, Andrikopoulos, Sofianos, Müller, Oliver J., Rose, Adam J.

“…Dietary protein dilution (DPD) promotes metabolic-remodelling and -health but the precise nutritional components driving this response remain elusive. Here, by…”
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Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose by Creek, Darren J, Mazet, Muriel, Achcar, Fiona, Anderson, Jana, Kim, Dong-Hyun, Kamour, Ruwida, Morand, Pauline, Millerioux, Yoann, Biran, Marc, Kerkhoven, Eduard J, Chokkathukalam, Achuthanunni, Weidt, Stefan K, Burgess, Karl E V, Breitling, Rainer, Watson, David G, Bringaud, Frédéric, Barrett, Michael P

“…Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form trypomastigotes…”
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Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action by Creek, Darren J, Chua, Hwa H, Cobbold, Simon A, Nijagal, Brunda, MacRae, James I, Dickerman, Benjamin K, Gilson, Paul R, Ralph, Stuart A, McConville, Malcolm J

“…High-throughput phenotypic screening of chemical libraries has resulted in the identification of thousands of compounds with potent antimalarial activity,…”
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Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics by Trochine, Andrea, Creek, Darren J, Faral-Tello, Paula, Barrett, Michael P, Robello, Carlos

“…The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of…”
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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria by Charman, Susan A., Arbe-Barnes, Sarah, Bathurst, Ian C., Brun, Reto, Campbell, Michael, Charman, William N., Chiu, Francis C. K., Chollet, Jacques, Craft, J. Carl, Creek, Darren J., Dong, Yuxiang, Matile, Hugues, Maurer, Melanie, Morizzi, Julia, Nguyen, Tien, Papastogiannidis, Petros, Scheurer, Christian, Shackleford, David M., Sriraghavan, Kamaraj, Stingelin, Lukas, Tang, Yuanqing, Urwyler, Heinrich, Wang, Xiaofang, White, Karen L., Wittlin, Sergio, Zhou, Lin, Vennerstrom, Jonathan L., Wellems, Thomas E.

“…Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase…”
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Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method by Langston-Cox, Annie, Anderson, Dovile, Creek, Darren J, Palmer, Kirsten, Wallace, Euan M, Marshall, Sarah A

“…(1) Background: There is increasing understanding of the potential health benefits of cruciferous vegetables. In particular sulforaphane (SFN), found in…”
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System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion by Giannangelo, Carlo, Siddiqui, Ghizal, De Paoli, Amanda, Anderson, Bethany M, Edgington-Mitchell, Laura E, Charman, Susan A, Creek, Darren J

“…Ozonide antimalarials, OZ277 (arterolane) and OZ439 (artefenomel), are synthetic peroxide-based antimalarials with potent activity against the deadliest…”
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Current and emerging target identification methods for novel antimalarials by Challis, Matthew P., Devine, Shane M., Creek, Darren J.

“…New antimalarial compounds with novel mechanisms of action are urgently needed to combat the recent rise in antimalarial drug resistance. Phenotypic…”
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Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii by Kloehn, Joachim, Oppenheim, Rebecca D, Siddiqui, Ghizal, De Bock, Pieter-Jan, Kumar Dogga, Sunil, Coute, Yohann, Hakimi, Mohamed-Ali, Creek, Darren J, Soldati-Favre, Dominique

“…Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational…”
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BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei by Oppenheim, Rebecca D, Creek, Darren J, Macrae, James I, Modrzynska, Katarzyna K, Pino, Paco, Limenitakis, Julien, Polonais, Valerie, Seeber, Frank, Barrett, Michael P, Billker, Oliver, McConville, Malcolm J, Soldati-Favre, Dominique

“…While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies…”
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Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials by Creek, Darren J, Charman, William N, Chiu, Francis C K, Prankerd, Richard J, Dong, Yuxiang, Vennerstrom, Jonathan L, Charman, Susan A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate by Counihan, Natalie A, Chisholm, Scott A, Bullen, Hayley E, Srivastava, Anubhav, Sanders, Paul R, Jonsdottir, Thorey K, Weiss, Greta E, Ghosh, Sreejoyee, Crabb, Brendan S, Creek, Darren J, Gilson, Paul R, de Koning-Ward, Tania F

“…parasites, the causative agents of malaria, modify their host erythrocyte to render them permeable to supplementary nutrient uptake from the plasma and for…”
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Promising antimalarial hits from phenotypic screens: a review of recently-described multi-stage actives and their modes of action by Luo, Annie-Peiyuan, Giannangelo, Carlo, Siddiqui, Ghizal, Creek, Darren J

“…Over the last two decades, global malaria cases caused by have declined due to the implementation of effective treatments and the use of insecticides. However,…”
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Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei by CREEK, Darren J, NIJAGAL, Brunda, KIM, Dong-Hyun, ROJAS, Federico, MATTHEWS, Keith R, BARRETT, Michael P

“…OA  Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Non‐canonical metabolic pathways in the malaria parasite detected by isotope‐tracing metabolomics by Cobbold, Simon A, V Tutor, Madel, Frasse, Philip, McHugh, Emma, Karnthaler, Markus, Creek, Darren J, Odom John, Audrey, Tilley, Leann, Ralph, Stuart A, McConville, Malcolm J

“…The malaria parasite, Plasmodium falciparum , proliferates rapidly in human erythrocytes by actively scavenging multiple carbon sources and essential nutrients…”
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