Search Results - "Creaven, Patrick J"

A Phase I Pharmacokinetic and Pharmacodynamic Study of Intravenous Calcitriol in Combination with Oral Gefitinib in Patients with Advanced Solid Tumors by FAKIH, Marwan G, TRUMP, Donald L, JOHNSON, Candace S, MUINDI, Josephia R, BLACK, Jennifer D, BERNARDI, Ronald J, CREAVEN, Patrick J, SCHWARTZ, James, BRATTAIN, Michael G, HUTSON, Alan, FRENCH, Renee

“…Purpose: In preclinical models, calcitriol and the tyrosine kinase inhibitor gefitinib are synergistic and modulate extracellular signal-regulated kinase (Erk)…”
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A Phase I Pharmacokinetic and Pharmacodynamic Study of S-3304, a Novel Matrix Metalloproteinase Inhibitor, in Patients with Advanced and Refractory Solid Tumors by CHIAPPORI, Alberto A, ECKHARDT, S. Gail, MEKHAIL, Tarek, O'BRYANT, Cindy L, CREAVEN, Patrick J, BUKOWSKI, Ronald, SULLIVAN, Daniel M, IKEDA, Minoru, YANO, Yoshitaka, YAMADA-SAWADA, Takuko, KAMBAYASHI, Yoshikaze, TANAKA, Kazushige, JAVLE, Milind M

“…Purpose: Matrix metalloproteinases (MMP) play a fundamental role in cancer development and progression. S-3304 is a potent, orally active, noncytotoxic…”
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Celecoxib and Mucosal Protection: Translation from an Animal Model to a Phase I Clinical Trial of Celecoxib, Irinotecan, and 5-Fluorouracil by JAVIE, Milind M, SHOUSONG CAO, DURRANI, Farukh A, PENDYALA, Lakshmi, LAWRENCE, David D, SMITH, Patrick F, CREAVEN, Patrick J, NOEL, Diane C, LYER, Renuka V, RUSTUM, Youcef M

“…Purpose: Chemotherapy-induced diarrhea occurs secondary to mucosal inflammation and may be cyclooxygenase-2 mediated. Cyclooxygenase-2 inhibitors may…”
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A phase I and pharmacokinetic study of fixed-dose selenomethionine and irinotecan in solid tumors by FAKIH, Marwan G, PENDYALA, Lakshmi, SMITH, Patrick F, CREAVEN, Patrick J, REID, Mary E, BADMAEV, Vladimir, AZRAK, Rami G, PREY, Joshua D, LAWRENCE, David, RUSTUM, Youcef M

“…PURPOSE: We conducted a phase I study to determine the maximum tolerated dose (MTD) of irinotecan with fixed, nontoxic high dose of selenomethionine…”
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Phase I and Pharmacokinetic Study of Weekly Docetaxel, Cisplatin, and Daily Capecitabine in Patients with Advanced Solid Tumors by FAKIH, Marwan G, CREAVEN, Patrick J, ZAMBONI, William C, RAMNATH, Nithya, TRUMP, Donald, JAVLE, Milind, STRYCHOR, Sandra, REPINSKI, Trisha V. W, ZAMBONI, Beth A, SCHWARZ, James K, FRENCH, Renee A

“…Purpose: Docetaxel, cisplatin, and capecitabine are three active chemotherapeutic agents with different mechanisms of action. This phase I study investigated…”
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Matrix metalloproteinase inhibitors by Ramnath, Nithya, Creaven, Patrick J

“…Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are associated with the tumorigenic process. MMPs degrade the extracellular…”
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A Phase I and pharmacokinetic study of selenomethionine in combination with a fixed dose of irinotecan in solid tumors by Fakih, Marwan G., Pendyala, Lakshmi, Brady, William, Smith, Patrick F., Ross, Mary E., Creaven, Patrick J., Badmaev, Vladimir, Prey, Joshua D., Rustum, Youcef M.

“…Purpose We conducted a phase I study to determine the recommended dose of selenomethionine (SLM) in combination with irinotecan that consistently results in a…”
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Scheduled administration of low dose irinotecan before gemcitabine in the second line therapy of non-small cell lung cancer: a phase II study by Ramnath, Nithya, Yu, Jihnhee, Khushalani, Nikhil I, Gottlieb, Ronald H, Schwarz, James K, Iyer, Renuka V, Rustum, Youcef M, Creaven, Patrick J

“…We had previously demonstrated that low dose irinotecan (CPT-11) leads to increased accumulation of cells in S-phase and shows a therapeutic synergy with…”
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Phase I and pharmacokinetic study of anhydrovinblastine every 3 weeks in patients with refractory solid tumors by RAMNATH, Nithya, SCHWARTZ, Gary N, SMITH, Patrick, BONG, Daniel, KANTER, Peter, BERDZIK, Joanne, CREAVEN, Patrick J

“…Anhydrovinblastine (AVLB) is a novel semisynthetic vinca alkaloid. We conducted a phase I trial to determine the maximum tolerated dose (MTD), dose-limiting…”
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Intravenous Ifosfamide/Mesna Is Associated with Depletion of Plasma Thiols without Depletion of Leukocyte Glutathione by PENDYALA, L, CREAVEN, P. J, SCHWARTZ, G, MEROPOL, N. J, BOLANOWSKA-HIGDON, W, ZDANOWICZ, J, MURPHY, M, PEREZ, R

“…Depletion of cellular glutathione (GSH) enhances the efficacy of many anticancer agents in preclinical systems. Limited published data showing depletion of GSH…”
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Phase I/pharmacodynamic study of N-acetylcysteine/oltipraz in smokers : Early termination due to excessive toxicity by PENDYALA, Lakshmi, SCHWARTZ, Gary, BOLANOWSKA-HIGDON, Wanda, HITT, Sandra, ZDANOWICZ, Joseph, MURPHY, Michael, LAWRENCE, David, CREAVEN, Patrick J

“…An N-acetylcysteine (NAC)/oltipraz (OLZ) combination was studied in healthy volunteer smokers who received daily NAC (1200 mg/day) and were randomized to…”
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Oral uracil and Ftorafur plus leucovorin : pharmacokinetics and toxicity in patients with metastatic cancer by HO, Dah H, COVINGTON, Wendy, KURITANI, Jun, HAYAKAWA, Tomohisa, BROWN, Nita, LIN, San N, PAZDUR, Richard, HUO, Yuang-Yi, CREAVEN, Patrick J, RUSTUM, Youcef M, MEROPOL, Neal J, LASSERE, Yvonne

“…To assess the pharmacokinetics of Ftorafur (tegafur, FT), 5-fluorouracil (5-FU), and uracil in 31 cancer patients who were enrolled in phase I studies of oral…”
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Identification of cis-dichloro-bis-isopropylamine platinum(II) as a major metabolite of iproplatin in humans by Pendyala, L, Cowens, J W, Chheda, G B, Dutta, S P, Creaven, P J

“…Iproplatin is a quadrivalent second-generation platinum complex undergoing clinical evaluation. In plasma and urine of patients receiving this drug,…”
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Seizures associated with leucovorin administration in cancer patients by Meropol, N J, Creaven, P J, Petrelli, N J, White, R M, Arbuck, S G

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Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas by Au, J L, Rustum, Y M, Ledesma, E J, Mittelman, A, Creaven, P J

“…The effects of thymidine (dThd) coadministration on the pharmacokinetics and metabolism of 5-fluorouracil (FUra) were investigated in 29 colorectal cancer…”
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Preliminary studies of a novel oral fluoropyrimidine carbamate: capecitabine by Budman, D R, Meropol, N J, Reigner, B, Creaven, P J, Lichtman, S M, Berghorn, E, Behr, J, Gordon, R J, Osterwalder, B, Griffin, T

“…To evaluate the toxicology and pharmacology of an orally active fluoropyrimidine given as a continuous daily dose divided into two portions for 6 weeks, and to…”
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Characterization of cells obtained by mechanical and enzymatic means from human melanoma, sarcoma, and lung tumors by Slocum, H K, Pavelic, Z P, Rustum, Y M, Creaven, P J, Karakousis, C, Takita, H, Greco, W R

“…Characterization of cells comprising solid tumors will facilitate the rational design of cancer chemotherapy for individual patients. We have prepared cell…”
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Effect of renal function impairment on iproplatin pharmacokinetics and relation to toxicity by LAKSHMI PENDYALA, MADAJEWICZ, S, CREAVEN, P. J

“…The pharmacokinetics of iproplatin, a quadrivalent second-generation platinum complex the dose-limiting toxicity of which is myelosuppression, was studied in…”
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Growth of cell colonies in soft agar from biopsies of different human solid tumors by Pavelic, Z P, Slocum, H K, Rustum, Y M, Creaven, P J, Nowak, N J, Karakousis, C, Takita, H, Mittelman, A

“…Colony growth in soft agar of cells disaggregated from 87 solid tumor specimens was evaluated. Tumors were disaggregated by an enzymatic method consisting of…”
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Colony growth in soft agar of human melanoma, sarcoma, and lung carcinoma cells disaggregated by mechanical and enzymatic methods by Pavelic, Z P, Slocum, H K, Rustum, Y M, Creaven, P J, Karakousis, C, Takita, H

“…The effect of mechanical and enzymatic disaggregation on human malignant melanoma, soft-tissue sarcoma and lung carcinoma colony growth in soft agar was…”
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