Search Results - "Creasy, Caitlin"

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy by Sharma, Meenu, Khong, Hiep, Fa’ak, Faisal, Bentebibel, Salah-Eddine, Janssen, Louise M. E., Chesson, Brent C., Creasy, Caitlin A., Forget, Marie-Andrée, Kahn, Laura Maria S., Pazdrak, Barbara, Karki, Binisha, Hailemichael, Yared, Singh, Manisha, Vianden, Christina, Vennam, Srinivas, Bharadwaj, Uddalak, Tweardy, David J., Haymaker, Cara, Bernatchez, Chantale, Huang, Shixia, Rajapakshe, Kimal, Coarfa, Cristian, Hurwitz, Michael E., Sznol, Mario, Hwu, Patrick, Hoch, Ute, Addepalli, Murali, Charych, Deborah H., Zalevsky, Jonathan, Diab, Adi, Overwijk, Willem W.

“…High dose interleukin-2 (IL-2) is active against metastatic melanoma and renal cell carcinoma, but treatment-associated toxicity and expansion of suppressive…”
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PD-L1 expression and prognostic impact in glioblastoma by Nduom, Edjah K, Wei, Jun, Yaghi, Nasser K, Huang, Neal, Kong, Ling-Yuan, Gabrusiewicz, Konrad, Ling, Xiaoyang, Zhou, Shouhao, Ivan, Cristina, Chen, Jie Qing, Burks, Jared K, Fuller, Greg N, Calin, George A, Conrad, Charles A, Creasy, Caitlin, Ritthipichai, Krit, Radvanyi, Laszlo, Heimberger, Amy B

“…Therapeutic targeting of the immune checkpoints cytotoxic T-lymphocyte-associated molecule-4 (CTLA-4) and PD-1/PD-L1 has demonstrated tumor regression in…”
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Identification of distinct immune landscapes using an automated nine-color multiplex immunofluorescence staining panel and image analysis in paraffin tumor tissues by Parra, Edwin R., Zhai, Jie, Tamegnon, Auriole, Zhou, Nicolas, Pandurengan, Renganayaki Krishna, Barreto, Carmelia, Jiang, Mei, Rice, David C., Creasy, Caitlin, Vaporciyan, Ara A., Hofstetter, Wayne L., Tsao, Anne S., Wistuba, Ignacio I., Sepesi, Boris, Haymaker, Cara

“…Immune profiling is becoming a vital tool for identifying predictive and prognostic markers for translational studies. The study of the tumor microenvironment…”
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Multi-modal molecular programs regulate melanoma cell state by Andrews, Miles C., Oba, Junna, Wu, Chang-Jiun, Zhu, Haifeng, Karpinets, Tatiana, Creasy, Caitlin A., Forget, Marie-Andrée, Yu, Xiaoxing, Song, Xingzhi, Mao, Xizeng, Robertson, A. Gordon, Romano, Gabriele, Li, Peng, Burton, Elizabeth M., Lu, Yiling, Sloane, Robert Szczepaniak, Wani, Khalida M., Rai, Kunal, Lazar, Alexander J., Haydu, Lauren E., Bustos, Matias A., Shen, Jianjun, Chen, Yueping, Morgan, Margaret B., Wargo, Jennifer A., Kwong, Lawrence N., Haymaker, Cara L., Grimm, Elizabeth A., Hwu, Patrick, Hoon, Dave S. B., Zhang, Jianhua, Gershenwald, Jeffrey E., Davies, Michael A., Futreal, P. Andrew, Bernatchez, Chantale, Woodman, Scott E.

“…Melanoma cells display distinct intrinsic phenotypic states. Here, we seek to characterize the molecular regulation of these states using multi-omic analyses…”
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4-1BB Agonist Focuses CD8 + Tumor-Infiltrating T-Cell Growth into a Distinct Repertoire Capable of Tumor Recognition in Pancreatic Cancer by Sakellariou-Thompson, Donastas, Forget, Marie-Andrée, Creasy, Caitlin, Bernard, Vincent, Zhao, Li, Kim, Young Uk, Hurd, Mark W, Uraoka, Naohiro, Parra, Edwin Roger, Kang, Ya'an, Bristow, Christopher A, Rodriguez-Canales, Jaime, Fleming, Jason B, Varadhachary, Gauri, Javle, Milind, Overman, Michael J, Alvarez, Hector A, Heffernan, Timothy P, Zhang, Jianhua, Hwu, Patrick, Maitra, Anirban, Haymaker, Cara, Bernatchez, Chantale

“…Survival for pancreatic ductal adenocarcinoma (PDAC) patients is extremely poor and improved therapies are urgently needed. Tumor-infiltrating lymphocyte (TIL)…”
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Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma by Creasy, Caitlin A, Meng, Yuzhong Jeff, Forget, Marie-Andrée, Karpinets, Tatiana, Tomczak, Katarzyna, Stewart, Chip, Torres-Cabala, Carlos A, Pilon-Thomas, Shari, Sarnaik, Amod A, Mulé, James J, Garraway, Levi, Bustos, Matias, Zhang, Jianhua, Patel, Sapna P, Diab, Adi, Glitza, Isabella C, Yee, Cassian, Tawbi, Hussein, Wong, Michael K, McQuade, Jennifer, Hoon, Dave S B, Davies, Michael A, Hwu, Patrick, Amaria, Rodabe N, Haymaker, Cara, Beroukhim, Rameen, Bernatchez, Chantale

“…Adoptive cell therapy (ACT) of tumor-infiltrating lymphocytes (TIL) historically yields a 40%-50% response rate in metastatic melanoma. However, the…”
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Exposure to anti‐PD‐1 causes functional differences in tumor‐infiltrating lymphocytes in rare solid tumors by Creasy, Caitlin A., Forget, Marie‐Andrée, Singh, Gopal, Tapia, Coya, Xu, Mingxuan, Stephen, Bettzy, Sabir, Sharjeel, Meric‐Bernstam, Funda, Haymaker, Cara, Bernatchez, Chantale, Naing, Aung

“…The pervasive use of therapeutic antibodies targeting programmed cell death protein 1 (PD‐1) to boost anti‐tumor immunity has positioned this approach to…”
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Utilizing T-cell Activation Signals 1, 2, and 3 for Tumor-infiltrating Lymphocytes (TIL) Expansion: The Advantage Over the Sole Use of Interleukin-2 in Cutaneous and Uveal Melanoma by Tavera, René J, Forget, Marie-Andrée, Kim, Young Uk, Sakellariou-Thompson, Donastas, Creasy, Caitlin A, Bhatta, Ankit, Fulbright, Orenthial J, Ramachandran, Renjith, Thorsen, Shawne T, Flores, Esteban, Wahl, Arely, Gonzalez, Audrey M, Toth, Christopher, Wardell, Seth, Mansaray, Rahmatu, Radvanyi, Laszlo G, Gombos, Dan S, Patel, Sapna P, Hwu, Patrick, Amaria, Rodabe N, Bernatchez, Chantale, Haymaker, Cara

“…In this study, we address one of the major critiques for tumor-infiltrating lymphocyte (TIL) therapy-the time needed for proper expansion of a suitable…”
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187 Multi-omic single-cell profiling demonstrates that competition for fatty acids and fatty acid oxidation enables tumor-infiltrating lymphocyte function and survival by Paniagua, Melisa Angela, Haymaker, Cara, Adolacion, Jay R, An, Xingyue, Creasy, Caitlin, Fathi, Mohsen, Rezvan, Ali, Geiger, Tamar, Harel, Michal, Robinson, Jonathan, Amritkar, Amit, Woodman, Scott, Hwu, Patrick, Bernatchez, Chantale, Varadarajan, Navin

“…BackgroundAdoptive transfer of ex vivo expanded tumor-infiltrating lymphocytes (TIL) have shown durable responses in metastatic melanoma, yet these responses…”
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Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy by Cascone, Tina, McKenzie, Jodi A., Mbofung, Rina M., Punt, Simone, Wang, Zhe, Xu, Chunyu, Williams, Leila J., Wang, Zhiqiang, Bristow, Christopher A., Carugo, Alessandro, Peoples, Michael D., Li, Lerong, Karpinets, Tatiana, Huang, Lu, Malu, Shruti, Creasy, Caitlin, Leahey, Sara E., Chen, Jiong, Chen, Yuan, Pelicano, Helen, Bernatchez, Chantale, Gopal, Y.N. Vashisht, Heffernan, Timothy P., Hu, Jianhua, Wang, Jing, Amaria, Rodabe N., Garraway, Levi A., Huang, Peng, Yang, Peiying, Wistuba, Ignacio I., Woodman, Scott E., Roszik, Jason, Davis, R. Eric, Davies, Michael A., Heymach, John V., Hwu, Patrick, Peng, Weiyi

“…Adoptive T cell therapy (ACT) produces durable responses in some cancer patients; however, most tumors are refractory to ACT and the molecular mechanisms…”
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Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy by Peng, Weiyi, Chen, Jie Qing, Liu, Chengwen, Malu, Shruti, Creasy, Caitlin, Tetzlaff, Michael T, Xu, Chunyu, McKenzie, Jodi A, Zhang, Chunlei, Liang, Xiaoxuan, Williams, Leila J, Deng, Wanleng, Chen, Guo, Mbofung, Rina, Lazar, Alexander J, Torres-Cabala, Carlos A, Cooper, Zachary A, Chen, Pei-Ling, Tieu, Trang N, Spranger, Stefani, Yu, Xiaoxing, Bernatchez, Chantale, Forget, Marie-Andree, Haymaker, Cara, Amaria, Rodabe, McQuade, Jennifer L, Glitza, Isabella C, Cascone, Tina, Li, Haiyan S, Kwong, Lawrence N, Heffernan, Timothy P, Hu, Jianhua, Bassett, Jr, Roland L, Bosenberg, Marcus W, Woodman, Scott E, Overwijk, Willem W, Lizée, Gregory, Roszik, Jason, Gajewski, Thomas F, Wargo, Jennifer A, Gershenwald, Jeffrey E, Radvanyi, Laszlo, Davies, Michael A, Hwu, Patrick

“…T cell-mediated immunotherapies are promising cancer treatments. However, most patients still fail to respond to these therapies. The molecular determinants of…”
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Abstract PR15: CD74 regulated inflammatory pattern is associated with TIL growth and favorable response to adoptive immunotherapy by Dai-Ogata, Creasy, Caitlin A., Kim, Sun-Hee, Roszik, Jason, Hwu, Patrick, Grimm, Elizabeth A., Bernatchez, Chantale, Ekmekcioglu, Suhendan

“…Abstract We previously reported that in Stage III melanoma patients’ tumors, positive expression of CD74 together with low or absent Macrophage Migration…”
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Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy by Chacon, Jessica Ann, Sarnaik, Amod A, Chen, Jie Qing, Creasy, Caitlin, Kale, Charuta, Robinson, John, Weber, Jeffrey, Hwu, Patrick, Pilon-Thomas, Shari, Radvanyi, Laszlo

“…Cultured tumor fragments from melanoma metastases have been used for years as a source of tumor-infiltrating lymphocytes (TIL) for adoptive cell therapy (ACT)…”
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Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome by Forget, Marie-Andrée, Haymaker, Cara, Hess, Kenneth R, Meng, Yuzhong Jeff, Creasy, Caitlin, Karpinets, Tatiana, Fulbright, Orenthial J, Roszik, Jason, Woodman, Scott E, Kim, Young Uk, Sakellariou-Thompson, Donastas, Bhatta, Ankit, Wahl, Arely, Flores, Esteban, Thorsen, Shawne T, Tavera, René J, Ramachandran, Renjith, Gonzalez, Audrey M, Toth, Christopher L, Wardell, Seth, Mansaray, Rahmatu, Patel, Vruti, Carpio, Destiny Joy, Vaughn, Carol, Farinas, Chantell M, Velasquez, Portia G, Hwu, Wen-Jen, Patel, Sapna P, Davies, Michael A, Diab, Adi, Glitza, Isabella C, Tawbi, Hussein, Wong, Michael K, Cain, Suzanne, Ross, Merrick I, Lee, Jeffrey E, Gershenwald, Jeffrey E, Lucci, Anthony, Royal, Richard, Cormier, Janice N, Wargo, Jennifer A, Radvanyi, Laszlo G, Torres-Cabala, Carlos A, Beroukhim, Rameen, Hwu, Patrick, Amaria, Rodabe N, Bernatchez, Chantale

“…Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) has consistently demonstrated clinical efficacy in metastatic melanoma. Recent…”
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Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma by Kalaora, Shelly, Wolf, Yochai, Feferman, Tali, Barnea, Eilon, Greenstein, Erez, Reshef, Dan, Tirosh, Itay, Reuben, Alexandre, Patkar, Sushant, Levy, Ronen, Quinkhardt, Juliane, Omokoko, Tana, Qutob, Nouar, Golani, Ofra, Zhang, Jianhua, Mao, Xizeng, Song, Xingzhi, Bernatchez, Chantale, Haymaker, Cara, Forget, Marie-Andrée, Creasy, Caitlin, Greenberg, Polina, Carter, Brett W, Cooper, Zachary A, Rosenberg, Steven A, Lotem, Michal, Sahin, Ugur, Shakhar, Guy, Ruppin, Eytan, Wargo, Jennifer A, Friedman, Nir, Admon, Arie, Samuels, Yardena

“…The quest for tumor-associated antigens (TAA) and neoantigens is a major focus of cancer immunotherapy. Here, we combine a neoantigen prediction pipeline and…”
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Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy by Terranova, Christopher J., Tang, Ming, Maitituoheti, Mayinuer, Raman, Ayush T., Ghosh, Archit K., Schulz, Jonathan, Amin, Samir B., Orouji, Elias, Tomczak, Katarzyna, Sarkar, Sharmistha, Oba, Junna, Creasy, Caitlin, Wu, Chang-Jiun, Khan, Samia, Lazcano, Rossana, Wani, Khalida, Singh, Anand, Barrodia, Praveen, Zhao, Dongyu, Chen, Kaifu, Haydu, Lauren E., Wang, Wei-Lien, Lazar, Alexander J., Woodman, Scott E., Bernatchez, Chantale, Rai, Kunal

“…The dynamic evolution of chromatin state patterns during metastasis, their relationship with bona fide genetic drivers, and their therapeutic vulnerabilities…”
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Abstract PR03: Nongenomic BAP1 aberrancy drives highly aggressive cutaneous melanoma phenotype by Zhu, Haifeng, Oba, Junna, Yu, Xiaoxing, Creasy, Caitlin A., Forget, Marie-Andrée, Carapeto, Fernando, Haymaker, Cara L., Wu, Chang-Jiun, Karpinets, Tatiana V., Wang, Wei-Lien, Tetzlaff, Michael T., Lazar, Alexander J., Mills, Gordon B., Moore, Amanda R., Chen, Yu, Zhang, Jianhua, Gershenwald, Jeffrey E., Wargo, Jennifer A., Bernatchez, Chantale, Hwu, Patrick, Futreal, P. Andrew, Woodman, Scott E.

“…Abstract The purpose of this study was to determine the role of BAP1 levels in cutaneous melanoma (CM). BAP1 is a tumor suppressor in which loss of…”
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Integrated profiling of T cells and tumor cells demonstrates metabolic adaptation essential for melanoma cell therapy by Martinez-Paniagua, Melisa A, Haymaker, Cara, Adolacion, Jay R T, An, Xingyue, Bandey, Irfan N, Creasy, Caitlin, Geiger, Tamar, Harel, Michal, Robinson, Jonathan, Nielsen, Jens B, Amritkar, Amit, Woodman, Scott, Roysam, Badrinath, Hwu, Patrick, Bernatchez, Chantale, Varadarajan, Navin

“…Abstract T cell-based therapies have shown promising results, but adoptive T cell therapy (ACT) for solid tumors like melanoma treatment has met limited…”
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IL2 Variant Circumvents ICOS+ Regulatory T-cell Expansion and Promotes NK Cell Activation by Sim, Geok Choo, Liu, Chengwen, Wang, Ena, Liu, Hui, Creasy, Caitlin, Dai, Zhimin, Overwijk, Willem W, Roszik, Jason, Marincola, Francesco, Hwu, Patrick, Grimm, Elizabeth, Radvanyi, Laszlo

“…Clinical responses to high-dose IL2 therapy are limited due to selective expansion of CD4 CD25 Foxp3 T-regulatory cells (Treg), especially ICOS Tregs, rather…”
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Metastatic Melanoma Patient Had a Complete Response with Clonal Expansion after Whole Brain Radiation and PD-1 Blockade by Haymaker, Cara L, Kim, DaeWon, Uemura, Marc, Vence, Luis M, Phillip, Ann, McQuail, Natalie, Brown, Paul D, Fernandez, Irina, Hudgens, Courtney W, Creasy, Caitlin, Hwu, Wen-Jen, Sharma, Padmanee, Tetzlaff, Michael T, Allison, James P, Hwu, Patrick, Bernatchez, Chantale, Diab, Adi

“…We report here on a patient with metastatic melanoma who had extensive brain metastases. After being treated with the sequential combination of whole brain…”
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