Search Results - "Crean, Conor"

Oxidative DNA Damage Associated with Combination of Guanine and Superoxide Radicals and Repair Mechanisms via Radical Trapping by Misiaszek, Richard, Crean, Conor, Joffe, Avrum, Geacintov, Nicholas E, Shafirovich, Vladimir

“…In living tissues under inflammatory conditions, superoxide radicals ( ) are generated and are known to cause oxidative DNA damage. However, the mechanisms of…”
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Oxidation of single-stranded oligonucleotides by carbonate radical anions: generating intrastrand cross-links between guanine and thymine bases separated by cytosines by Crean, Conor, Uvaydov, Yuriy, Geacintov, Nicholas E, Shafirovich, Vladimir

“…The carbonate radical anion is a biologically important one-electron oxidant that can directly abstract an electron from guanine, the most easily oxidizable…”
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Absolute Configurations of Spiroiminodihydantoin and Allantoin Stereoisomers: Comparison of Computed and Measured Electronic Circular Dichroism Spectra by Ding, Shuang, Jia, Lei, Durandin, Alexander, Crean, Conor, Kolbanovskiy, Alexander, Shafirovich, Vladimir, Broyde, Suse, Geacintov, Nicholas E

“…The assignment of absolute configurations is of critical importance for understanding the biochemical processing of DNA lesions. The diastereomeric…”
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United Nations Office on Drugs and Crime: Recommended methods for the Identification and Analysis of Synthetic Cannabinoid Receptor Agonists in Seized Materials by Tettey, Justice N.A., Crean, Conor, Rodrigues, Joao, Angeline Yap, Tiong Whei, Lee Wendy Lim, Jong, Shirley Lee, Hui Zhi, Ching Ong, Mei

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Methylation of 2′-Deoxyguanosine by a Free Radical Mechanism by Crean, Conor, Geacintov, Nicholas E, Shafirovich, Vladimir

“…The mechanistic aspects of the methylation of guanine in DNA initiated by methyl radicals that are derived from the metabolic oxidation of some chemical…”
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Functionalization of C60 via organometallic reagents by Champeil, Elise, Crean, Conor, Larraya, Carlos, Pescitelli, Gennaro, Proni, Gloria, Ghosez, Léon

“…The reaction of [60]fullerene with organolithium and Grignard reagents carrying orthoester, acetal or other end groups yielded adducts 3– 5 at the 6–6 bond of…”
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New psychoactive substances: catalysing a shift in forensic science practice? by Tettey, Justice, Crean, Conor

“…The analysis of substances of abuse remains one of the most matured areas in forensic science with a strong scientific basis, namely analytical chemistry. The…”
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New psychoactive substances: catalysing a shift in forensic science practice? by Justice Tettey, Crean, Conor

“…The analysis of substances of abuse remains one of the most matured areas in forensic science with a strong scientific basis, namely analytical chemistry. The…”
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Combination Reactions of Superoxide with 8-Oxo-7,8-dihydroguanine Radicals in DNA by Misiaszek, Richard, Uvaydov, Yuriy, Crean, Conor, Geacintov, Nicholas E., Shafirovich, Vladimir

“…One of the major biomarkers of oxidative stress and oxidative damage of cellular DNA is 8-oxo-7,8-dihydroguanine (8-oxoGua), which is more easily oxidized than…”
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Synthesis of N3- and 2-NH2-substituted 6,7-diphenylpterins and their use as intermediates for the preparation of oligonucleotide conjugates designed to target photooxidative damage on single-stranded DNA representing the bcr-abl chimeric gene by Crean, Conor W, Camier, Russell, Lawler, Mark, Stevenson, Clarke, Davies, R Jeremy H, Boyle, Peter H, Kelly, John M

“…Two 17-mer oligodeoxynucleotide-5'-linked-(6,7-diphenylpterin) conjugates, 2 and 3, were prepared as photosensitisers for targeting photooxidative damage to a…”
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Thermodynamic Profiles and Nuclear Magnetic Resonance Studies of Oligonucleotide Duplexes Containing Single Diastereomeric Spiroiminodihydantoin Lesions by Khutsishvili, Irine, Zhang, Na, Marky, Luis A, Crean, Conor, Patel, Dinshaw J, Geacintov, Nicholas E, Shafirovich, Vladimir

“…The spiroiminodihydantoins (Sp) are highly mutagenic oxidation products of guanine and 8-oxo-7,8-dihydroguanine in DNA. The Sp lesions have recently been…”
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Toxicology in international drug control—Prioritizing the most harmful, persistent and prevalent substances by Ifeagwu, Susan C, Raithelhuber, Martin, Crean, Conor, Gerostamoulos, Dimitri, Cheung, Heesun, Tettey, Justice N

“…Abstract The nature of the global drugs market has evolved rapidly and become more complex with the emergence of new psychoactive substances (NPS), some of…”
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Intrastrand G-U cross-links generated by the oxidation of guanine in 5′-d(GCU) and 5′-r(GCU) by Crean, Conor, Geacintov, Nicholas E., Shafirovich, Vladimir

“…It has been suggested that carbonate radical anions are biologically important because they may be produced during the inflammatory response. The carbonate…”
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Oxidation of Guanine and 8-oxo-7,8-Dihydroguanine by Carbonate Radical Anions: Insight from Oxygen-18 Labeling Experiments by Crean, Conor, Geacintov, Nicholas E., Shafirovich, Vladimir

“…Under oxidative stress: The oxidation of guanine and 8‐oxo‐7,8‐dihydroguanine has been monitored by 18O‐labeling methods. The combination of nucleobase…”
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Thermodynamic Profiles and NMR Studies of Oligonucleotide Duplexes Containing Single Diastereomeric Spiroiminodihydantoin Lesions by Khutsishvili, Irine, Zhang, Na, Marky, Luis A., Crean, Conor, Patel, Dinshaw J., Geacintov, Nicholas E., Shafirovich, Vladimir

“…The spiroiminodihydantoins (Sp) are highly mutagenic oxidation products of guanine and 8-oxo-7,8-dihydroguanine in DNA. The Sp lesions have been recently…”
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Histamine determination in human urine using sub-2 μm C18 column with fluorescence and mass spectrometric detection by Hogan, Anna-Marie, Crean, Conor, Barrett, Una Marie, Guihen, Elizabeth, Glennon, Jeremy D

“…A fast, sensitive, and selective method for the determination of histamine in human urine samples by ultrahigh pressure liquid chromatography (LC) with…”
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Pathways of Arachidonic Acid Peroxyl Radical Reactions and Product Formation with Guanine Radicals by Crean, Conor, Geacintov, Nicholas E, Shafirovich, Vladimir

“…Peroxyl radicals were derived from the one-electron oxidation of polyunsaturated fatty acids by sulfate radicals that were generated by the photodissociation…”
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Histamine determination in human urine using sub-2 µm C18 column with fluorescence and mass spectrometric detection by Hogan, Anna-Marie, Crean, Conor, Barrett, Una Marie, Guihen, Elizabeth, Glennon, Jeremy D

“…A fast, sensitive, and selective method for the determination of histamine in human urine samples by ultrahigh pressure liquid chromatography (LC) with…”
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Combination of Nitrogen Dioxide Radicals with 8-Oxo-7,8-dihydroguanine and Guanine Radicals in DNA:  Oxidation and Nitration End-Products by Misiaszek, Richard, Crean, Conor, Geacintov, Nicholas E, Shafirovich, Vladimir

“…The oxidation and nitration reactions in DNA associated with the combination of nitrogen dioxide radicals with 8-oxo-7,8-dihydroguanine (8-oxoGua) and guanine…”
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Oxidation of Guanine by Carbonate Radicals Derived from Photolysis of Carbonatotetramminecobalt(III) Complexes and the pH Dependence of Intrastrand DNA Cross-Links Mediated by Guanine Radical Reactions by Crean, Conor, Lee, Young Ae, Yun, Byeong Hwa, Geacintov, Nicholas E, Shafirovich, Vladimir

“…The carbonate radical anion CO₃.⁻ is a decomposition product of nitrosoperoxycarbonate derived from the combination of carbon dioxide and peroxynitrite, an…”
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