Search Results - "Crawley, S C"

Mucin gene and antigen expression in biliopancreatic carcinogenesis by Kim, Y. S., Gum, J. R., Crawley, S. C., Deng, G., Ho, J. J. L.

“…Mucins are high molecular weight glycoproteins which are heavily glycosylated with many carbohydrate side chains. In epithelial cancers such as biliopancreatic…”
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MUC17, a Novel Membrane-Tethered Mucin by Gum, James R., Crawley, Suzanne C., Hicks, James W., Szymkowski, David E., Kim, Young S.

“…Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and…”
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A trisaccharide acceptor analog for N-acetylglucosaminyltransferase V which binds to the enzyme but sterically precludes the transfer reaction by KHAN, S. H, CRAWLEY, S. C, KANIE, O, HINDSGAUL, O

“…Development of inhibitors specific for the glycosyltransferases involved in the biosynthesis of asparagine-linked sugar chains has been undertaken in the hopes…”
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Evaluation of deoxygenated oligosaccharide acceptor analogs as specific inhibitors of glycosyltransferases by Hindsgaul, O, Kaur, K J, Srivastava, G, Blaszczyk-Thurin, M, Crawley, S C, Heerze, L D, Palcic, M M

“…The glycosyltransferases controlling the biosynthesis of cell-surface complex carbohydrates transfer glycosyl residues from sugar nucleotides to specific…”
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Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing by Terdiman, Jonathan P., Gum, James R., Conrad, Peggy G., Miller, Glenn A., Weinberg, Vivian, Crawley, Suzanne C., Levin, Theodore R., Reeves, Cynthia, Schmitt, Anna, Hepburn, Michael, Sleisenger, Marvin H., Kim, Young S.

“…Background & Aims: The optimal strategy for the detection of hereditary nonpolyposis colorectal cancer (HNPCC) gene carriers remains uncertain. We evaluated…”
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Genomic Organization and Structure of the 3′ Region of Human MUC3: Alternative Splicing Predicts Membrane-Bound and Soluble Forms of the Mucin by Crawley, Suzanne C., Gum, James R., Hicks, James W., Pratt, Wendy S., Aubert, Jean-Pierre, Swallow, Dallas M., Kim, Young S.

“…The MUC3 gene encodes a large, glycosylated mucin produced by intestinal epithelial cells to form a protective barrier against the external environment…”
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Initiation of Transcription of the MUC3A Human Intestinal Mucin from a TATA-less Promoter and Comparison with the MUC3B Amino Terminus by Gum, James R., Hicks, James W., Crawley, Suzanne C., Dahl, Christine M., Yang, Stacey C., Roberton, Anthony M., Kim, Young S.

“…Human intestinal mucin genes MUC3A and MUC3B are members of a membrane mucin gene family residing at chromosome 7q22. In this paper, we utilized genomic and…”
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An enzyme-linked immunosorbent assay for N-acetylglucosaminyltransferase-V by Crawley, S C, Hindsgaul, O, Alton, G, Pierce, M, Palcic, M M

“…The development of an enzyme-linked immunosorbent assay (ELISA) for uridine 5'-diphospho-N-acetyl-glucosamine: alpha mannoside beta 1---6…”
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A plant fucosyltransferase with human Lewis blood-group specificity by Crawley, S C, Hindsgaul, O, Ratcliffe, R M, Lamontagne, L R, Palcic, M M

“…A fucosyltransferase from mung bean seedling was found to transfer L-fucose from GDP-fucose to the Type 1 disaccharide beta-D-Galp-(1---3)-beta-D-GlcpNAc-OR [R…”
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Expression of connective tissue growth factor in pancreatic cancer cell lines by KWON, Sungwon, MUNROE, Xander, CRAWLEY, Suzanne C, HWA YOUNG LEE, SPONG, Suzanne, BRADHAM, Douglass, GUM, James R, SLEISENGER, Marvin H, KIM, Young S

“…Connective tissue growth factor (CTGF/CCN2) is thought to play a role in normal wound repair and bone remodeling, but also promotes fibrosis in several disease…”
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Acceptor-substrate recognition by N-acetylglucosaminyltransferase-V: critical role of the 4"-hydroxyl group in beta-D-GlcpNAc-(1-->2)-alpha-D-Manp(1-->6)-beta-D-Glcp-OR by Kanie, O, Crawley, S C, Palcic, M M, Hindsgaul, O

“…The enzyme N-acetylglucosaminyltransferase-V (GlcNAcT-V) transfers GlcNAc from UDP-GlcNAc to the OH-6' group of oligosaccharides terminating in the sequence…”
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Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas by Kim, Grace E., Bae, Han–Ik, Park, Hee–Ug, Kuan, Shih–Fan, Crawley, Suzanne C., Ho, Jenny J.L., Kim, Young S.

“…Background & Aims: It has recently been suggested that infiltrating adenocarcinoma of the pancreas arises from histologically well-defined precursor ductal…”
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Vasoactive intestinal peptide upregulates MUC2 intestinal mucin via CREB/ATF1 by Hokari, Ryota, Lee, Hwayoung, Crawley, Suzanne C, Yang, Stacey C, Gum, Jr, James R, Miura, Soichiro, Kim, Young S

“…VIP exerts a spectrum of effects as a potent anti-inflammatory factor. In addition, VIP increases expression of MUC2, a major intestinal secretory mucin. We…”
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Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B by Lee, Hae-Wan, Ahn, Dae-Ho, Crawley, Suzanne C, Li, Jian-Dong, Gum, Jr, James R, Basbaum, Carol B, Fan, Nancy Q, Szymkowski, David E, Han, Sang-Young, Lee, Bong H, Sleisenger, Marvin H, Kim, Young S

“…MUC2 is a secretory mucin normally expressed by goblet cells of the intestinal epithelium. It is overexpressed in mucinous type colorectal cancers but…”
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TNF-alpha Activates MUC2 Transcription via NF-kappaB but Inhibits via JNK Activation by Ahn, Dae, Crawley, Suzanne, Hokari, Ryota, Kato, Shingo, Yang, Stacey, Li, Jian, Kim, Young

“…The molecular mechanisms responsible for TNF-α-mediated MUC2 intestinal mucin up-regulation in HM3 colon adenocarcinoma cells were analyzed using…”
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Phorbol 12-Myristate 13-Acetate Up-regulates the Transcription of MUC2 Intestinal Mucin via Ras, ERK, and NF-[kappa]B by Lee, H, Ahn, D, Crawley, S C, Li, J, Jr, Gum, Basbaum, C B, Fan, N Q, Szymkowski, D, Han, S, Lee, B H, Sleisenger, M H, Kim, Y S

“…MUC2 is a secretory mucin normally expressed by goblet cells of the intestinal epithelium. It is overexpressed in mucinous type colorectal cancers but…”
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Recognition of the acceptor beta-D-GlcpNAc-(1-->2)-alpha-D-Manp- (1-->6)-beta-D-Glcp-OR by N-acetyl-glucosaminyltransferase-V: none of the hydroxyl groups on the Glc-residue are important by Linker, T, Crawley, S C, Hindsgaul, O

“…The enzyme, N-acetylglucosaminyltransferase-V (GlcNAcT-V, E.C. 2.4.1.155), transfer a beta-D-GlcpNAc residue, from UDP-GlcNAc, to the OH-6 group of the Man…”
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Key involvement of all three GlcNAc hydroxyl groups in the recognition of beta-D-GlcpNAc-(1-->2)-alpha-D-Manp-(1-->6)-beta-D-Glcp-OR by N-acetylglucosaminyltransferase-V by Kanie, O, Crawley, S C, Palcic, M M, Hindsgaul, O

“…N-Acetylglucosaminyltransferase-V (GlcNAc T-V) transfers a beta-linked GlcNAc residue from UDP-GlcNAc to OH-6' (of the alpha Man residue) in oligosaccharides…”
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A Nutrition Education Intervention on Achieving Healthy Weights Among Adolescents for Nutrition Educators for Low-Income Families by Kaus, Melissa, BS, Lee, J.S., PhD, RD, Lewis, R.D., PhD, RD, Crawley, C., MS, RD

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Using the Child as Change Agent for Preventing Childhood Obesity in Rural Georgia: Baseline Findings by Davis, Marsha, PhD, Christiana, R., PhD, Still, C., MS, RD, Oliver, C., MA, Crawley, C., MS, RD, Mullis, R., PhD, RD, Lewis, R., PhD

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