Search Results - "Crawley, Oliver"

Ubiquitin ligase activity inhibits Cdk5 to control axon termination by Desbois, Muriel, Opperman, Karla J, Amezquita, Jonathan, Gaglio, Gabriel, Crawley, Oliver, Grill, Brock

“…The Cdk5 kinase plays prominent roles in nervous system development, plasticity, behavior and disease. It also has important, non-neuronal functions in cancer,…”
Get full text

Autophagy is inhibited by ubiquitin ligase activity in the nervous system by Crawley, Oliver, Opperman, Karla J., Desbois, Muriel, Adrados, Isabel, Borgen, Melissa A., Giles, Andrew C., Duckett, Derek R., Grill, Brock

“…Autophagy is an intracellular catabolic process prominent in starvation, aging and disease. Neuronal autophagy is particularly important, as it affects…”
Get full text

The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1 by Castellano-Pozo, Maikel, Sioutas, Georgios, Barroso, Consuelo, Prince, Josh P, Lopez-Jimenez, Pablo, Davy, Joseph, Jaso-Tamame, Angel-Luis, Crawley, Oliver, Shao, Nan, Page, Jesus, Martinez-Perez, Enrique

“…The cohesin complex plays essential roles in chromosome segregation, 3D genome organisation, and DNA damage repair through its ability to modify DNA topology…”
Get full text

POSTNATAL CONNECTIVITY OF CALLOSAL PROJECTION NEURONS IS DISRUPTED BY LOSS OF THE NMDA RECEPTOR SUBUNIT GLUN3A by Crawley, Oliver, Corral-Sanchez, Barbara, Navarro, Ana Isabel, Mico, Sara, Herrera, Eloísa, Otano, Isabel

Get full text

Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes by Crawley, Oliver, Barroso, Consuelo, Testori, Sarah, Ferrandiz, Nuria, Silva, Nicola, Castellano-Pozo, Maikel, Jaso-Tamame, Angel Luis, Martinez-Perez, Enrique

“…Wapl induces cohesin dissociation from DNA throughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin structure…”
Get full text

Protein phosphatase 4 promotes chromosome pairing and synapsis, and contributes to maintaining crossover competence with increasing age by Sato-Carlton, Aya, Li, Xuan, Crawley, Oliver, Testori, Sarah, Martinez-Perez, Enrique, Sugimoto, Asako, Carlton, Peter M

“…Prior to the meiotic divisions, dynamic chromosome reorganizations including pairing, synapsis, and recombination of maternal and paternal chromosome pairs…”
Get full text

The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis by Nadarajan, Saravanapriah, Mohideen, Firaz, Tzur, Yonatan B, Ferrandiz, Nuria, Crawley, Oliver, Montoya, Alex, Faull, Peter, Snijders, Ambrosius P, Cutillas, Pedro R, Jambhekar, Ashwini, Blower, Michael D, Martinez-Perez, Enrique, Harper, J Wade, Colaiacovo, Monica P

“…Asymmetric disassembly of the synaptonemal complex (SC) is crucial for proper meiotic chromosome segregation. However, the signaling mechanisms that directly…”
Get full text

A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning by Crawley, Oliver, Giles, Andrew C, Desbois, Muriel, Kashyap, Sudhanva, Birnbaum, Rayna, Grill, Brock

“…The Pam/Highwire/RPM-1 (PHR) proteins are conserved intracellular signaling hubs that regulate synapse formation and axon termination. The C. elegans PHR…”
Get full text

Autophagy in axonal and presynaptic development by Crawley, Oliver, Grill, Brock

“…The study of autophagy in the nervous system has predominantly centered on degeneration. Evidence is now cementing crucial roles for autophagy in neuronal…”
Get full text

Abstract 1447: Ubiquitin ligase activity inhibits Cdk5 to control axon termination by Desbois, Muriel, Opperman, Karla, Amezquita, Jonathan, Gaglio, Gabriel, Crawley, Oliver, Grill, Brock

Get full text

GluN3A NMDA receptor subunits: more enigmatic than ever? by Crawley, Oliver, Conde‐Dusman, María J., Pérez‐Otaño, Isabel

“…Non‐conventional N‐methyl‐d‐aspartate receptors (NMDARs) containing GluN3A subunits have unique biophysical, signalling and localization properties within the…”
Get full text

PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2 by Desbois, Muriel, Crawley, Oliver, Evans, Paul R., Baker, Scott T., Masuho, Ikuo, Yasuda, Ryohei, Grill, Brock

“…PHR (PAM/Highwire/RPM-1) proteins are conserved RING E3 ubiquitin ligases that function in developmental processes, such as axon termination and synapse…”
Get full text

PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2 by Desbois, Muriel, Crawley, Oliver, Evans, Paul R., Baker, Scott T., Masuho, Ikuo, Yasuda, Ryohei, Grill, Brock

“…PHR (PAM/Highwire/RPM‐1) proteins are conserved RING E3 ubiquitin ligases that function in developmental processes, such as axon termination and synapse…”
Get full text

ATM/ATR kinases link the synaptonemal complex and DNA double-strand break repair pathway choice by Láscarez-Lagunas, Laura I., Nadarajan, Saravanapriah, Martinez-Garcia, Marina, Quinn, Julianna N., Todisco, Elena, Thakkar, Tanuj, Berson, Elizaveta, Eaford, Don, Crawley, Oliver, Montoya, Alex, Faull, Peter, Ferrandiz, Nuria, Barroso, Consuelo, Labella, Sara, Koury, Emily, Smolikove, Sarit, Zetka, Monique, Martinez-Perez, Enrique, Colaiácovo, Monica P.

“…DNA double-strand breaks (DSBs) are deleterious lesions, which must be repaired precisely to maintain genomic stability. During meiosis, programmed DSBs are…”
Get full text

Protein Phosphatase 4 Promotes Chromosome Pairing and Synapsis, and Contributes to Maintaining Crossover Competence with Increasing Age: e1004638 by Sato-Carlton, Aya, Li, Xuan, Crawley, Oliver, Testori, Sarah, Martinez-Perez, Enrique, Sugimoto, Asako, Carlton, Peter M

“…Prior to the meiotic divisions, dynamic chromosome reorganizations including pairing, synapsis, and recombination of maternal and paternal chromosome pairs…”
Get full text

Investigating the regulation of cohesin dynamics during meiotic prophase in c elegans by Crawley, Oliver

“…The physical linking of sister chromatids after S-phase is known as sister chromatid cohesion (SCC) and is largely provided by the cohesin complex. The…”
Get full text