Search Results - "Crawley, James T B"

Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor by Crawley, James T.B., de Groot, Rens, Xiang, Yaozu, Luken, Brenda M., Lane, David A.

“…von Willebrand factor (VWF) is a large adhesive glycoprotein with established functions in hemostasis. It serves as a carrier for factor VIII and acts as a…”
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Conformational activation of ADAMTS13 by South, Kieron, Luken, Brenda M., Crawley, James T. B., Phillips, Rebecca, Thomas, Mari, Collins, Richard F., Deforche, Louis, Vanhoorelbeke, Karen, Lane, David A.

“…Significance We show that a CUB–spacer domain interaction impedes exposure of the ADAMTS13 spacer functional exosite, preventing ADAMTS13 from interacting…”
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High VWF, low ADAMTS13, and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women by Andersson, Helena M., Siegerink, Bob, Luken, Brenda M., Crawley, James T.B., Algra, Ale, Lane, David A., Rosendaal, Frits R.

“…VWF and ADAMTS13 are major determinants of platelet adhesion after vessel injury. In the present study, we aimed to determine whether VWF or ADAMTS13 plasma…”
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ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men by Chion, Chan K.N.K., Doggen, Carine J.M., Crawley, James T.B., Lane, David A., Rosendaal, Frits R.

“…Von Willebrand factor (VWF) mediates the tethering/adhesion of platelets at sites of vascular injury. This function depends on its multimeric size, which is…”
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Crystal structure and substrate-induced activation of ADAMTS13 by Petri, Anastasis, Kim, Hyo Jung, Xu, Yaoxian, de Groot, Rens, Li, Chan, Vandenbulcke, Aline, Vanhoorelbeke, Karen, Emsley, Jonas, Crawley, James T. B.

“…Platelet recruitment to sites of blood vessel damage is highly dependent upon von Willebrand factor (VWF). VWF platelet-tethering function is proteolytically…”
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Protective effects of non-anticoagulant activated protein C variant (D36A/L38D/A39V) in a murine model of ischaemic stroke by Andreou, Anna P, Efthymiou, Maria, Yu, Yao, Watts, Helena R, Noormohamed, Faruq H, Ma, Daqing, Lane, David A, Crawley, James T B

“…Ischaemic stroke is caused by occlusive thrombi in the cerebral vasculature. Although tissue-plasminogen activator (tPA) can be administered as thrombolytic…”
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Platelet-Neutrophil Crosstalk in Thrombosis by Mereweather, Laura J, Constantinescu-Bercu, Adela, Crawley, James T B, Salles-Crawley, Isabelle I

“…Platelets are essential for the formation of a haemostatic plug to prevent bleeding, while neutrophils are the guardians of our immune defences against…”
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Thrombotic thrombocytopenic purpura: basic pathophysiology and therapeutic strategies by Crawley, James T B, Scully, Marie A

“…VWF is a multimeric plasma glycoprotein that specifically recruits platelets to sites of vessel injury. VWF multimeric size is central to this function, with…”
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The GPIbα intracellular tail - role in transducing VWF- and collagen/GPVI-mediated signaling by Constantinescu-Bercu, Adela, Wang, Yuxiao A, Woollard, Kevin J, Mangin, Pierre, Vanhoorelbeke, Karen, Crawley, James T B, Salles-Crawley, Isabelle I

“…The GPIbT-VWF A1 domain interaction is essential for platelet tethering under high shear. Synergy between GPIbα and GPVI signaling machineries has been…”
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An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF by Pos, Wouter, Crawley, James T.B., Fijnheer, Rob, Voorberg, Jan, Lane, David A., Luken, Brenda M.

“…In the majority of patients with acquired thrombotic thrombocytopenic purpura (TTP), antibodies are directed toward the spacer domain of ADAMTS13. We have…”
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The Haemostatic Role of Tissue Factor Pathway Inhibitor by Crawley, James T.B, Lane, David A

“…Under normal conditions the blood circulates freely within the confines of the vascular system, carrying oxygen, nutrients, and hormonal information around the…”
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Identification of functionally important residues in TFPI Kunitz domain 3 required for the enhancement of its activity by protein S by Ahnström, Josefin, Andersson, Helena M., Hockey, Verity, Meng, Yiran, McKinnon, Thomas A.J., Hamuro, Tsutomu, Crawley, James T.B., Lane, David A.

“…Protein S is a cofactor for tissue factor pathway inhibitor (TFPI) that critically reduces the inhibition constant for FXa to below the plasma concentration of…”
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Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) by Xiang, Yaozu, de Groot, Rens, Crawley, James T.B, Lane, David A

“…The platelet-tethering function of von Willebrand factor (VWF) is proteolytically regulated by ADAMTS13 (a disintegrin and metalloproteinase with a…”
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Essential role of the disintegrin-like domain in ADAMTS13 function by de Groot, Rens, Bardhan, Ajoy, Ramroop, Nalisha, Lane, David A., Crawley, James T.B.

“…ADAMTS13 is a highly specific multidomain plasma metalloprotease that regulates the multimeric size and function of von Willebrand factor (VWF) through…”
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Detection of anti‐platelet antibodies in immune thrombocytopenia by flow cytometry by Teraz‐Orosz, Adrienn, Cooper, Nichola, Crawley, James T.B., Salles‐Crawley, Isabelle I.

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Proteolytic inactivation of ADAMTS13 by thrombin and plasmin by Crawley, James T.B., Lam, Jonathan K., Rance, James B., Mollica, Luigina R., O'Donnell, James S., Lane, David A.

“…The multimeric size and the function of circulating von Willebrand factor are modulated via its proteolytic cleavage by the plasma metalloproteinase, ADAMTS13…”
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Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2 by Constantinescu-Bercu, Adela, Grassi, Luigi, Frontini, Mattia, Salles-Crawley, Isabelle I, Woollard, Kevin, Crawley, James TB

“…Platelet-neutrophil interactions are important for innate immunity, but also contribute to the pathogenesis of deep vein thrombosis, myocardial infarction and…”
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The ADAMTS13 metalloprotease domain: roles of subsites in enzyme activity and specificity by de Groot, Rens, Lane, David A., Crawley, James T.B.

“…ADAMTS13 modulates von Willebrand factor (VWF) platelet-tethering function by proteolysis of the Tyr1605-Met1606 bond in the VWF A2 domain. To examine the role…”
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Activated protein C cofactor function of protein S: a novel role for a γ-carboxyglutamic acid residue by Ahnström, Josefin, Andersson, Helena M., Canis, Kevin, Norstrøm, Eva, Yu, Yao, Dahlbäck, Björn, Panico, Maria, Morris, Howard R., Crawley, James T.B., Lane, David A.

“…Protein S has an important anticoagulant function by acting as a cofactor for activated protein C (APC). We recently reported that the EGF1 domain residue…”
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Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain by Andersson, Helena M., Arantes, Márcia J., Crawley, James T.B., Luken, Brenda M., Tran, Sinh, Dahlbäck, Björn, Lane, David A., Rezende, Suely M.

“…Protein S has an established role in the protein C anticoagulant pathway, where it enhances the factor Va (FVa) and factor VIIIa (FVIIIa) inactivating property…”
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