Search Results - "Crawford, Nyree T"

BRD7, a Subunit of SWI/SNF Complexes, Binds Directly to BRCA1 and Regulates BRCA1-Dependent Transcription by HARTE, Mary T, O'BRIEN, Garrett J, RYAN, Niamh M, GORSKI, Julia J, SAVAGE, Kienan I, CRAWFORD, Nyree T, MULLAN, Paul B, HARKIN, D. Paul

“…We carried out a yeast two-hybrid screen using a BRCA1 bait composed of amino acids 1 to 1142 and identified BRD7 as a novel binding partner of BRCA1. This…”
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A revised model of TRAIL‐R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis by Humphreys, Luke M, Fox, Jennifer P, Higgins, Catherine A, Majkut, Joanna, Sessler, Tamas, McLaughlin, Kirsty, McCann, Christopher, Roberts, Jamie Z, Crawford, Nyree T, McDade, Simon S, Scott, Christopher J, Harrison, Timothy, Longley, Daniel B

“…The long FLIP splice form FLIP(L) can act as both an inhibitor and promoter of caspase‐8 at death‐inducing signalling complexes (DISCs) formed by death…”
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The pseudo-caspase FLIP(L) regulates cell fate following p53 activation by Lees, Andrea, McIntyre, Alexander J., Crawford, Nyree T., Falcone, Fiammetta, McCann, Christopher, Holohan, Caitriona, Quinn, Gerard P., Roberts, Jamie Z., Sessler, Tamas, Gallagher, Peter F., Gregg, Gemma M. A., McAllister, Katherine, McLaughlin, Kirsty M., Allen, Wendy L., Egan, Laurence J., Ryan, Aideen E., Labonte-Wilson, Melissa J., Dunne, Philip D., Wappett, Mark, Coyle, Vicky M., Johnston, Patrick G., Kerr, Emma M., Longley, Daniel B., McDade, Simon S.

“…p53 is the most frequently mutated, well-studied tumor-suppressor gene, yet the molecular basis of the switch from p53-induced cellcycle arrest to apoptosis…”
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BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers by Buckley, Niamh E, Nic An tSaoir, Caoimhe B, Blayney, Jaine K, Oram, Lisa C, Crawford, Nyree T, D'Costa, Zenobia C, Quinn, Jennifer E, Kennedy, Richard D, Harkin, D Paul, Mullan, Paul B

“…Here, we show for the first time, that the familial breast/ovarian cancer susceptibility gene BRCA1 activates the Notch pathway in breast cells by…”
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PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy by Armstrong, Chris W D, Maxwell, Pamela J, Ong, Chee Wee, Redmond, Kelly M, McCann, Christopher, Neisen, Jessica, Ward, George A, Chessari, Gianni, Johnson, Christopher, Crawford, Nyree T, LaBonte, Melissa J, Prise, Kevin M, Robson, Tracy, Salto-Tellez, Manuel, Longley, Daniel B, Waugh, David J J

“…PTEN loss is prognostic for patient relapse post-radiotherapy in prostate cancer (CaP). Infiltration of tumor-associated macrophages (TAMs) is associated with…”
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The ΔNp63 Proteins Are Key Allies of BRCA1 in the Prevention of Basal-Like Breast Cancer by BUCKLEY, Niamh E, CONLON, Susan J, JOHNSTON, Patrick G, KENNEDY, Richard D, PAUL HARKIN, D, MULLAN, Paul B, JIRSTROM, Karin, KAY, Elaine W, CRAWFORD, Nyree T, O'GRADY, Anthony, SHEEHAN, Katherine, MC DADE, Simon S, WANG, Ching-Wei, MCCANCE, Dennis J

“…Abstract Little is known about the origin of basal-like breast cancers, an aggressive disease that is highly similar to BRCA1-mutant breast cancers. p63 family…”
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TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities by D'Costa, Zenobia C, Higgins, Catherine, Ong, Chee Wee, Irwin, Gareth W, Boyle, David, McArt, Darragh G, McCloskey, Karen, Buckley, Niamh E, Crawford, Nyree T, Thiagarajan, Lalitha, Murray, James T, Kennedy, Richard D, Mulligan, Karl A, Harkin, D Paul, Waugh, David J J, Scott, Chris J, Salto-Tellez, Manuel, Williams, Richard, Mullan, Paul B

“…TBX2 is an oncogenic transcription factor known to drive breast cancer proliferation. We have identified the cysteine protease inhibitor Cystatin 6 (CST6) as a…”
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Machine vision based stochastic analysis of cancer cell mitochondrial dysfunction induced by a BH3 domain by Chacko, Alex D, Crawford, Nyree T, Johnston, Patrick G, Fennell, Dean A

“…We have developed a versatile and rapid method for the quantitative estimation of cell death kinetics, following direct single-shot activation of the…”
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Abstract 4399: Entinostat sensitizes colorectal cancer cell lines to the IAP antagonist, ASTX660 by down-regulating FLIP expression by Crawford, Nyree T., Stott, Katie, Smyth, Tomoko, Lyons, John, Ferraldeschi, Roberta, Ward, George, Longley, Daniel B.

“…Abstract Introduction Inhibitor of Apoptosis Proteins (IAPs) are anti-apoptotic proteins which suppress the activation of caspases. IAPs have been shown to be…”
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Abstract 2049: Characterization of a novel BRCA1-EGR1 interaction by Dickson, Naomi A., Crawford, Nyree T., Mullan, Paul B.

“…Abstract The tumor suppressor protein BRCA1 orchestrates DNA repair and cell cycle arrest following DNA damage, with transcriptional regulation integral to…”
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Abstract 2409: FLIP(L) determines colon cancer cell fate following p53 activation by Lees, Andrea, McIntyre, Alexander J. McIntyre J., Crawford, Nyree T., Falcone, Fiammetta, McCann, Chris, Quinn, Gerard P., Roberts, Jamie Z., Sessler, Thomas, Gallagher, Peter F., Gregg, Gemma M., McAllister, Katherine, McLaughlin, Kirsty M., Allen, Wendy L., Holohan, Caitriona, Egan, Laurence J., Ryan, Aideen E., Labonte-Wilson, Melissa, Dunne, Phillip D., Wappett, Mark, Coye, Vicky M., Johnston, Patrick G., Kerr, Emma M., Longley, Daniel B., McDade, Simon S.

“…Abstract Background: How p53 differentially activates cell cycle arrest versus cell death remains poorly understood. Understanding the mechanisms governing the…”
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Abstract 2290: Rational targeting of inhibitor of apoptosis proteins (IAPs) for effective therapy of colorectal cancer by Crawford, Nyree T., Dunne, Philip D., Johnston, Patrick G., Waugh, David J., Longley, Daniel B.

“…Abstract Background Inhibitor of Apoptosis Proteins (IAPs) are anti-apoptotic proteins which suppress the activation of caspases. IAP proteins have been shown…”
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The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancer by Buckley, Niamh E, Conlon, Susan J, Jirstrom, Karin, Kay, Elaine W, Crawford, Nyree T, O'Grady, Anthony, Sheehan, Katherine, Mc Dade, Simon S, Wang, Ching-Wei, McCance, Dennis J, Johnston, Patrick G, Kennedy, Richard D, Harkin, D Paul, Mullan, Paul B

“…Little is known about the origin of basal-like breast cancers, an aggressive disease that is highly similar to BRCA1-mutant breast cancers. p63 family proteins…”
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The {Delta}Np63 Proteins Are Key Allies of BRCA1 in the Prevention of Basal-Like Breast Cancer by Buckley, Niamh E, Conlon, Susan J, Jirström, Karin, Kay, Elaine W, Crawford, Nyree T, O'Grady, Anthony, Sheehan, Katherine, Mc Dade, Simon S, Wang, Ching-Wei, McCance, Dennis J, Johnston, Patrick G, Kennedy, Richard D, Harkin, D Paul, Mullan, Paul B

“…Little is known about the origin of basal-like breast cancers, an aggressive disease that is highly similar to BRCA1-mutant breast cancers. p63 family proteins…”
Get full text