Search Results - "Crawford, Katharine H D"

A human coronavirus evolves antigenically to escape antibody immunity by Eguia, Rachel T, Crawford, Katharine H D, Stevens-Ayers, Terry, Kelnhofer-Millevolte, Laurel, Greninger, Alexander L, Englund, Janet A, Boeckh, Michael J, Bloom, Jesse D

“…There is intense interest in antibody immunity to coronaviruses. However, it is unknown if coronaviruses evolve to escape such immunity, and if so, how…”
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Serological identification of SARS-CoV-2 infections among children visiting a hospital during the initial Seattle outbreak by Dingens, Adam S., Crawford, Katharine H. D., Adler, Amanda, Steele, Sarah L., Lacombe, Kirsten, Eguia, Rachel, Amanat, Fatima, Walls, Alexandra C., Wolf, Caitlin R., Murphy, Michael, Pettie, Deleah, Carter, Lauren, Qin, Xuan, King, Neil P., Veesler, David, Krammer, Florian, Dickerson, Jane A., Chu, Helen Y., Englund, Janet A., Bloom, Jesse D.

“…Children are strikingly underrepresented in COVID-19 case counts. In the United States, children represent 22% of the population but only 1.7% of confirmed…”
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Dynamics of Neutralizing Antibody Titers in the Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Crawford, Katharine H D, Dingens, Adam S, Eguia, Rachel, Wolf, Caitlin R, Wilcox, Naomi, Logue, Jennifer K, Shuey, Kiel, Casto, Amanda M, Fiala, Brooke, Wrenn, Samuel, Pettie, Deleah, King, Neil P, Greninger, Alexander L, Chu, Helen Y, Bloom, Jesse D

“…Abstract Most individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop neutralizing antibodies that target the viral…”
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Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays by Crawford, Katharine H D, Eguia, Rachel, Dingens, Adam S, Loes, Andrea N, Malone, Keara D, Wolf, Caitlin R, Chu, Helen Y, Tortorici, M Alejandra, Veesler, David, Murphy, Michael, Pettie, Deleah, King, Neil P, Balazs, Alejandro B, Bloom, Jesse D

“…SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera…”
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Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection by Greaney, Allison J, Loes, Andrea N, Gentles, Lauren E, Crawford, Katharine H D, Starr, Tyler N, Malone, Keara D, Chu, Helen Y, Bloom, Jesse D

“…The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with mutations in key antibody epitopes has raised concerns that…”
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Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice by Loes, Andrea N, Gentles, Lauren E, Greaney, Allison J, Crawford, Katharine H D, Bloom, Jesse D

“…An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here, we describe an influenza virus-based vaccine for SARS-CoV-2. We…”
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Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design by Ellis, Daniel, Brunette, Natalie, Crawford, Katharine H. D., Walls, Alexandra C., Pham, Minh N., Chen, Chengbo, Herpoldt, Karla-Luise, Fiala, Brooke, Murphy, Michael, Pettie, Deleah, Kraft, John C., Malone, Keara D., Navarro, Mary Jane, Ogohara, Cassandra, Kepl, Elizabeth, Ravichandran, Rashmi, Sydeman, Claire, Ahlrichs, Maggie, Johnson, Max, Blackstone, Alyssa, Carter, Lauren, Starr, Tyler N., Greaney, Allison J., Lee, Kelly K., Veesler, David, Bloom, Jesse D., King, Neil P.

“…The unprecedented global demand for SARS-CoV-2 vaccines has demonstrated the need for highly effective vaccine candidates that are thermostable and amenable to…”
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Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies by Greaney, Allison J., Loes, Andrea N., Crawford, Katharine H.D., Starr, Tyler N., Malone, Keara D., Chu, Helen Y., Bloom, Jesse D.

“…The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-mediated immunity. To facilitate prospective surveillance for such…”
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Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate by Addetia, Amin, Crawford, Katharine H D, Dingens, Adam, Zhu, Haiying, Roychoudhury, Pavitra, Huang, Meei-Li, Jerome, Keith R, Bloom, Jesse D, Greninger, Alexander L

“…The development of vaccines against SARS-CoV-2 would be greatly facilitated by the identification of immunological correlates of protection in humans. However,…”
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Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition by Greaney, Allison J., Starr, Tyler N., Gilchuk, Pavlo, Zost, Seth J., Binshtein, Elad, Loes, Andrea N., Hilton, Sarah K., Huddleston, John, Eguia, Rachel, Crawford, Katharine H.D., Dingens, Adam S., Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Rothlauf, Paul W., Liu, Zhuoming, Whelan, Sean P.J., Carnahan, Robert H., Crowe, James E., Bloom, Jesse D.

“…Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed as therapeutics and are a major contributor to neutralizing…”
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Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding by Starr, Tyler N., Greaney, Allison J., Hilton, Sarah K., Ellis, Daniel, Crawford, Katharine H.D., Dingens, Adam S., Navarro, Mary Jane, Bowen, John E., Tortorici, M. Alejandra, Walls, Alexandra C., King, Neil P., Veesler, David, Bloom, Jesse D.

“…The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor and is a major determinant of host range and…”
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A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike by Dadonaite, Bernadeta, Crawford, Katharine H.D., Radford, Caelan E., Farrell, Ariana G., Yu, Timothy C., Hannon, William W., Zhou, Panpan, Andrabi, Raiees, Burton, Dennis R., Liu, Lihong, Ho, David D., Chu, Helen Y., Neher, Richard A., Bloom, Jesse D.

“…A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and functional effects of emerging mutations in the viral spike protein…”
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Performance characteristics of highly automated HSV-1 and HSV-2 IgG testing by Crawford, Katharine H D, Selke, Stacy, Pepper, Gregory, Goecker, Erin, Sobel, Aniela, Wald, Anna, Johnston, Christine, Greninger, Alexander L

“…Herpes simplex virus (HSV) infections are one of the most common and stigmatized infections of humankind, affecting more than 4 billion people around the world…”
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Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning by Radford, Caelan E., Schommers, Philipp, Gieselmann, Lutz, Crawford, Katharine H.D., Dadonaite, Bernadeta, Yu, Timothy C., Dingens, Adam S., Overbaugh, Julie, Klein, Florian, Bloom, Jesse D.

“…Understanding the specificities of human serum antibodies that broadly neutralize HIV can inform prevention and treatment strategies. Here, we describe a deep…”
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Deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex by Carr, Caleb R, Crawford, Katharine H D, Murphy, Michael, Galloway, Jared G, Haddox, Hugh K, Matsen, 4th, Frederick A, Andersen, Kristian G, King, Neil P, Bloom, Jesse D

“…Lassa virus is estimated to cause thousands of human deaths per year, primarily due to spillovers from its natural host, Mastomys rodents. Efforts to create…”
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Epitope profiling reveals binding signatures of SARS-CoV-2 immune response in natural infection and cross-reactivity with endemic human CoVs by Stoddard, Caitlin I., Galloway, Jared, Chu, Helen Y., Shipley, Mackenzie M., Sung, Kevin, Itell, Hannah L., Wolf, Caitlin R., Logue, Jennifer K., Magedson, Ariana, Garrett, Meghan E., Crawford, Katharine H.D., Laserson, Uri, Matsen, Frederick A., Overbaugh, Julie

“…A major goal of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine efforts is to elicit antibody responses that confer protection…”
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Severe Metabolic Derangements in a Patient with Hypertension and COVID-19 by Crawford, Katharine H D, Doerner, Diane, Rainey, Petrie M, Phipps, William S

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Phage-DMS: A Comprehensive Method for Fine Mapping of Antibody Epitopes by Garrett, Meghan E., Itell, Hannah L., Crawford, Katharine H.D., Basom, Ryan, Bloom, Jesse D., Overbaugh, Julie

“…Understanding the antibody response is critical to developing vaccine and antibody-based therapies and has inspired the recent development of new methods to…”
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Pseudotyped Lentiviral Systems for Studying Viral Entry Proteins from Emerging Viruses with Pandemic Potential by Crawford, Katharine H. D

“…Viral entry proteins facilitate viral entry into host cells through receptor binding and membrane fusion. They play a critical role in the viral life cycle…”
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alignparse: A Python package for parsing complex features from high-throughput long-read sequencing by Crawford, Katharine H D, Bloom, Jesse D

“…Advances in sequencing technology have made it possible to generate large numbers of long, high-accuracy sequencing reads. For instance, the new PacBio Sequel…”
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