Search Results - "Crawford, Howard C."

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions by Liou, Geou-Yarh, Döppler, Heike, DelGiorno, Kathleen E., Zhang, Lizhi, Leitges, Michael, Crawford, Howard C., Murphy, Michael P., Storz, Peter

“…The development of pancreatic cancer requires the acquisition of oncogenic KRas mutations and upregulation of growth factor signaling, but the relationship…”
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Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer by Halbrook, Christopher J., Pontious, Corbin, Kovalenko, Ilya, Lapienyte, Laura, Dreyer, Stephan, Lee, Ho-Joon, Thurston, Galloway, Zhang, Yaqing, Lazarus, Jenny, Sajjakulnukit, Peter, Hong, Hanna S., Kremer, Daniel M., Nelson, Barbara S., Kemp, Samantha, Zhang, Li, Chang, David, Biankin, Andrew, Shi, Jiaqi, Frankel, Timothy L., Crawford, Howard C., Morton, Jennifer P., Pasca di Magliano, Marina, Lyssiotis, Costas A.

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant infiltration of tumor-associated macrophages (TAMs). TAMs have been reported to drive…”
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Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids by Huang, Ling, Holtzinger, Audrey, Jagan, Ishaan, BeGora, Michael, Lohse, Ines, Ngai, Nicholas, Nostro, Cristina, Wang, Rennian, Muthuswamy, Lakshmi B, Crawford, Howard C, Arrowsmith, Cheryl, Kalloger, Steve E, Renouf, Daniel J, Connor, Ashton A, Cleary, Sean, Schaeffer, David F, Roehrl, Michael, Tsao, Ming-Sound, Gallinger, Steven, Keller, Gordon, Muthuswamy, Senthil K

“…Human pluripotent stem cells can be differentiated into exocrine pancreas progenitor organoids, allowing studies of development and pancreatic cancer modeling…”
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Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer by Saloman, Jami L., Albers, Kathryn M., Li, Dongjun, Hartman, Douglas J., Crawford, Howard C., Muha, Emily A., Rhim, Andrew D., Davis, Brian M.

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by an exuberant inflammatory desmoplastic response. The PDAC microenvironment is complex, containing…”
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Loss of FOXA1/2 Is Essential for the Epithelial-to-Mesenchymal Transition in Pancreatic Cancer by YAN SONG, WASHINGTON, M. Kay, CRAWFORD, Howard C

“…FOXA1 and FOXA2, members of the forkhead transcription factor family, are critical for epithelial differentiation in many endoderm-derived organs, including…”
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Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption by Liu, Jun, Gao, Ming, Nipper, Michael, Deng, Janice, Sharkey, Francis E, Johnson, Randy L, Crawford, Howard C, Chen, Yidong, Wang, Pei

“…Damaged acinar cells play a passive role in activating pancreatic stellate cells (PSCs) via recruitment of immune cells that subsequently activate PSCs…”
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EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis by Ardito, Christine M., Grüner, Barbara M., Takeuchi, Kenneth K., Lubeseder-Martellato, Clara, Teichmann, Nicole, Mazur, Pawel K., DelGiorno, Kathleen E., Carpenter, Eileen S., Halbrook, Christopher J., Hall, Jason C., Pal, Debjani, Briel, Thomas, Herner, Alexander, Trajkovic-Arsic, Marija, Sipos, Bence, Liou, Geou-Yarh, Storz, Peter, Murray, Nicole R., Threadgill, David W., Sibilia, Maria, Washington, M. Kay, Wilson, Carole L., Schmid, Roland M., Raines, Elaine W., Crawford, Howard C., Siveke, Jens T.

“…Initiation of pancreatic ductal adenocarcinoma (PDA) is definitively linked to activating mutations in the KRAS oncogene. However, PDA mouse models show that…”
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iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling by Li, Xue, Maretzky, Thorsten, Weskamp, Gisela, Monette, Sébastien, Qing, Xiaoping, Issuree, Priya Darshinee A., Crawford, Howard C., McIlwain, David R., Mak, Tak W., Salmon, Jane E., Blobel, Carl P.

“…The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor (EGFR) signaling by liberating EGFR ligands from their membrane…”
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Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice by Perusina Lanfranca, Mirna, Zhang, Yaqing, Girgis, Alexander, Kasselman, Samantha, Lazarus, Jenny, Kryczek, Illona, Delrosario, Lawrence, Rhim, Andrew, Koneva, Lada, Sartor, Maureen, Sun, Lei, Halbrook, Christopher, Nathan, Hari, Shi, Jiaqi, Crawford, Howard C., Pasca di Magliano, Marina, Zou, Weiping, Frankel, Timothy L.

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that invades surrounding structures and metastasizes rapidly. Although inflammation is…”
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Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism by Bott, Alex J., Shen, Jianliang, Tonelli, Claudia, Zhan, Le, Sivaram, Nithya, Jiang, Ya-Ping, Yu, Xufen, Bhatt, Vrushank, Chiles, Eric, Zhong, Hua, Maimouni, Sara, Dai, Weiwei, Velasquez, Stephani, Pan, Ji-An, Muthalagu, Nathiya, Morton, Jennifer, Anthony, Tracy G., Feng, Hui, Lamers, Wouter H., Murphy, Daniel J., Guo, Jessie Yanxiang, Jin, Jian, Crawford, Howard C., Zhang, Lanjing, White, Eileen, Lin, Richard Z., Su, Xiaoyang, Tuveson, David A., Zong, Wei-Xing

“…Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid…”
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Discoidin Domain Receptor 1 (DDR1) Is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma by Ruggeri, Jeanine M., Franco-Barraza, Janusz, Sohail, Anjum, Zhang, Yaqing, Long, Daniel, Pasca di Magliano, Marina, Cukierman, Edna, Fridman, Rafael, Crawford, Howard C.

“…Pancreatic ductal adenocarcinoma (PDA) and chronic pancreatitis are characterized by a dense collagen-rich desmoplastic reaction. Discoidin domain receptor 1…”
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MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance by Farrell, Amy S., Joly, Meghan Morrison, Allen-Petersen, Brittany L., Worth, Patrick J., Lanciault, Christian, Sauer, David, Link, Jason, Pelz, Carl, Heiser, Laura M., Morton, Jennifer P., Muthalagu, Nathiya, Hoffman, Megan T., Manning, Sara L., Pratt, Erica D., Kendsersky, Nicholas D., Egbukichi, Nkolika, Amery, Taylor S., Thoma, Mary C., Jenny, Zina P., Rhim, Andrew D., Murphy, Daniel J., Sansom, Owen J., Crawford, Howard C., Sheppard, Brett C., Sears, Rosalie C.

“…Intratumoral phenotypic heterogeneity has been described in many tumor types, where it can contribute to drug resistance and disease recurrence. We analyzed…”
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PI3K Regulation of RAC1 Is Required for KRAS-Induced Pancreatic Tumorigenesis in Mice by Wu, Chia-Yen C, Carpenter, Eileen S, Takeuchi, Kenneth K, Halbrook, Christopher J, Peverley, Louise V, Bien, Harold, Hall, Jason C, DelGiorno, Kathleen E, Pal, Debjani, Song, Yan, Shi, Chanjuan, Lin, Richard Z, Crawford, Howard C

“…Background & Aims New drug targets are urgently needed for the treatment of patients with pancreatic ductal adenocarcinoma (PDA). Nearly all PDAs contain…”
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ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer by Purohit, Vinee, Wang, Lidong, Yang, Huibin, Li, Jiufeng, Ney, Gina M, Gumkowski, Erica R, Vaidya, Akash J, Wang, Annie, Bhardwaj, Amit, Zhao, Ende, Dolgalev, Igor, Zamperone, Andrea, Abel, Ethan V, Magliano, Marina Pasca Di, Crawford, Howard C, Diolaiti, Daniel, Papagiannakopoulos, Thales Y, Lyssiotis, Costas A, Simeone, Diane M

“…Pancreatic ductal adenocarcinoma is a lethal disease characterized by late diagnosis, propensity for early metastasis and resistance to chemotherapy. Little is…”
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Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer by Scales, Michael K, Velez-Delgado, Ashley, Steele, Nina G, Schrader, Hannah E, Stabnick, Anna M, Yan, Wei, Mercado Soto, Nayanna M, Nwosu, Zeribe C, Johnson, Craig, Zhang, Yaqing, Salas-Escabillas, Daniel J, Menjivar, Rosa E, Maurer, H Carlo, Crawford, Howard C, Bednar, Filip, Olive, Kenneth P, Pasca di Magliano, Marina, Allen, Benjamin L

“…Proper Hedgehog (HH) signaling is essential for embryonic development, while aberrant HH signaling drives pediatric and adult cancers. HH signaling is…”
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Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context by Kerk, Samuel A, Lin, Lin, Myers, Amy L, Sutton, Damien J, Andren, Anthony, Sajjakulnukit, Peter, Zhang, Li, Zhang, Yaqing, Jiménez, Jennifer A, Nelson, Barbara S, Chen, Brandon, Robinson, Anthony, Thurston, Galloway, Kemp, Samantha B, Steele, Nina G, Hoffman, Megan T, Wen, Hui-Ju, Long, Daniel, Ackenhusen, Sarah E, Ramos, Johanna, Gao, Xiaohua, Nwosu, Zeribe C, Galban, Stefanie, Halbrook, Christopher J, Lombard, David B, Piwnica-Worms, David R, Ying, Haoqiang, Pasca di Magliano, Marina, Crawford, Howard C, Shah, Yatrik M, Lyssiotis, Costas A

“…Mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2) is part of the malate-aspartate shuttle, a mechanism by which cells transfer reducing equivalents…”
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PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance by Roy, Nilotpal, Takeuchi, Kenneth K, Ruggeri, Jeanine M, Bailey, Peter, Chang, David, Li, Joey, Leonhardt, Laura, Puri, Sapna, Hoffman, Megan T, Gao, Shan, Halbrook, Christopher J, Song, Yan, Ljungman, Mats, Malik, Shivani, Wright, Christopher V E, Dawson, David W, Biankin, Andrew V, Hebrok, Matthias, Crawford, Howard C

“…Aberrant activation of embryonic signaling pathways is frequent in pancreatic ductal adenocarcinoma (PDA), making developmental regulators therapeutically…”
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Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4 by Catanzaro, Joseph M., Sheshadri, Namratha, Pan, Ji-An, Sun, Yu, Shi, Chanjuan, Li, Jinyu, Powers, R. Scott, Crawford, Howard C., Zong, Wei-Xing

“…Mounting evidence indicates that oncogenic Ras can modulate cell autonomous inflammatory cytokine production, although the underlying mechanism remains…”
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An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development by Shankar, Sunita, Tien, Jean Ching-Yi, Siebenaler, Ronald F., Chugh, Seema, Dommeti, Vijaya L., Zelenka-Wang, Sylvia, Wang, Xiao-Ming, Apel, Ingrid J., Waninger, Jessica, Eyunni, Sanjana, Xu, Alice, Mody, Malay, Goodrum, Andrew, Zhang, Yuping, Tesmer, John J., Mannan, Rahul, Cao, Xuhong, Vats, Pankaj, Pitchiaya, Sethuramasundaram, Ellison, Stephanie J., Shi, Jiaqi, Kumar-Sinha, Chandan, Crawford, Howard C., Chinnaiyan, Arul M.

“…Both KRAS and EGFR are essential mediators of pancreatic cancer development and interact with Argonaute 2 (AGO2) to perturb its function. Here, in a mouse…”
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Identification and Manipulation of Biliary Metaplasia in Pancreatic Tumors by DelGiorno, Kathleen E, Hall, Jason C, Takeuchi, Kenneth K, Pan, Fong Cheng, Halbrook, Christopher J, Washington, M. Kay, Olive, Kenneth P, R. Spence, Jason, Sipos, Bence, Wright, Christopher V.E, Wells, James M, Crawford, Howard C

“…Background & Aims Metaplasias often have characteristics of developmentally related tissues. Pancreatic metaplastic ducts are usually associated with…”
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