Search Results - "Crawford, Alexander D."

Seizing the moment: Zebrafish epilepsy models by Gawel, Kinga, Langlois, Melanie, Martins, Teresa, van der Ent, Wietske, Tiraboschi, Ettore, Jacmin, Maxime, Crawford, Alexander D., Esguerra, Camila V.

“…•Zebrafish is gaining recognition as a valuable model organism in epilepsy research•Zebrafish models allow for rapid identification of new drug leads•Genetic…”
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Evaluation of 14 organic solvents and carriers for screening applications in zebrafish embryos and larvae by Maes, Jan, Verlooy, Lien, Buenafe, Olivia E, de Witte, Peter A M, Esguerra, Camila V, Crawford, Alexander D

“…Zebrafish are rapidly growing in popularity as an in vivo model system for chemical genetics, drug discovery, and toxicology, and more recently also for…”
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Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs by Afrikanova, Tatiana, Serruys, Ann-Sophie K, Buenafe, Olivia E M, Clinckers, Ralph, Smolders, Ilse, de Witte, Peter A M, Crawford, Alexander D, Esguerra, Camila V

“…Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol…”
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Potential of zebrafish as a model for exploring the role of the amygdala in emotional memory and motivational behavior by Perathoner, Simon, Cordero-Maldonado, Maria Lorena, Crawford, Alexander D.

“…Emotion is a key aspect of behavior, enabling humans and animals to assign either positive or negative values to sensory inputs and thereby to make appropriate…”
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Zebrafish-based identification of the antiseizure nucleoside inosine from the marine diatom Skeletonema marinoi by Brillatz, Théo, Lauritano, Chiara, Jacmin, Maxime, Khamma, Supitcha, Marcourt, Laurence, Righi, Davide, Romano, Giovanna, Esposito, Francesco, Ianora, Adrianna, Queiroz, Emerson F, Wolfender, Jean-Luc, Crawford, Alexander D

“…With the goal of identifying neuroactive secondary metabolites from microalgae, a microscale in vivo zebrafish bioassay for antiseizure activity was used to…”
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Pharmacological characterization of an antisense knockdown zebrafish model of Dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramine by Zhang, Yifan, Kecskés, Angéla, Copmans, Daniëlle, Langlois, Mélanie, Crawford, Alexander D, Ceulemans, Berten, Lagae, Lieven, de Witte, Peter A M, Esguerra, Camila V

“…Dravet syndrome (DS) is one of the most pharmacoresistant and devastating forms of childhood epilepsy syndromes. Distinct de novo mutations in the SCN1A gene…”
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Anti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model by Chipiti, Talent, Viljoen, Alvaro M., Cordero-Maldonado, Maria L., Veale, Clinton G.L., Van Heerden, Fanie R., Sandasi, Maxleene, Chen, Weiyang, Crawford, Alexander D., Enslin, Gill M.

“…Epilepsy is one of the major chronic diseases that does not have a cure to date. Adverse drug reactions have been reported from the use of available…”
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Deoxyhypusine synthase deficiency syndrome zebrafish model: aberrant morphology, epileptiform activity, and reduced arborization of inhibitory interneurons by Shojaeinia, Elham, Mastracci, Teresa L, Soliman, Remon, Devinsky, Orrin, Esguerra, Camila V, Crawford, Alexander D

“…DHPS deficiency syndrome is an ultra-rare neurodevelopmental disorder (NDD) which results from biallelic mutations in the gene encoding the enzyme…”
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Zebrafish bioassay-guided isolation of antiseizure compounds from the Cameroonian medicinal plant Cyperus articulatus L by Brillatz, Théo, Jacmin, Maxime, Queiroz, Emerson Ferreira, Marcourt, Laurence, Slacanin, Ivan, Petit, Charlotte, Carrupt, Pierre-Alain, Bum, Elisabeth Ngo, Herrling, Paul, Crawford, Alexander D., Wolfender, Jean-Luc

“…Epilepsy is a chronic neurological disorder affecting more than 50 million people worldwide, of whom 80% live in low- and middle-income countries. Due to the…”
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Deep learning image recognition enables efficient genome editing in zebrafish by automated injections by Cordero-Maldonado, Maria Lorena, Perathoner, Simon, van der Kolk, Kees-Jan, Boland, Ralf, Heins-Marroquin, Ursula, Spaink, Herman P, Meijer, Annemarie H, Crawford, Alexander D, de Sonneville, Jan

“…One of the most popular techniques in zebrafish research is microinjection. This is a rapid and efficient way to genetically manipulate early developing…”
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Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate Synoicum sp by Kokkaliari, Sofia, Pham, Kim, Shahbazi, Nargess, Calcul, Laurent, Wojtas, Lukasz, Wilson, Nerida G, Crawford, Alexander D, Baker, Bill J

“…Five new alkaloids have been isolated from the lipophilic extract of the Antarctic tunicate sp. Deep-sea specimens of sp. were collected during a 2011 cruise…”
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CaSiAn: a Calcium Signaling Analyzer tool by Moein, Mahsa, Grzyb, Kamil, Gonçalves Martins, Teresa, Komoto, Shinya, Peri, Francesca, Crawford, Alexander D, Fouquier d'Herouel, Aymeric, Skupin, Alexander

“…Abstract Summary Ca2+ is a central second messenger in eukaryotic cells that regulates many cellular processes. Recently, we have indicated that typical Ca2+…”
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Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B by Copmans, Daniëlle, Kildgaard, Sara, Rasmussen, Silas A, Ślęzak, Monika, Dirkx, Nina, Partoens, Michèle, Esguerra, Camila V, Crawford, Alexander D, Larsen, Thomas O, de Witte, Peter A M

“…There is a high need for the development of new and improved antiseizure drugs (ASDs) to treat epilepsy. Despite the potential of marine natural products…”
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Type 2 Iodothyronine Deiodinase Is Essential for Thyroid Hormone-Dependent Embryonic Development and Pigmentation in Zebrafish by Walpita, Chaminda N, Crawford, Alexander D, Janssens, Els D. R, Van der Geyten, Serge, Darras, Veerle M

“…Despite the known importance of thyroid hormones (THs) in vertebrate growth and development, the role of tissue-specific TH activation in early embryogenesis…”
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Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants by Crawford, Alexander D, Liekens, Sandra, Kamuhabwa, Appolinary R, Maes, Jan, Munck, Sebastian, Busson, Roger, Rozenski, Jef, Esguerra, Camila V, de Witte, Peter A M

“…Natural products represent a significant reservoir of unexplored chemical diversity for early-stage drug discovery. The identification of lead compounds of…”
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Identification of GSK‑3 as a Potential Therapeutic Entry Point for Epilepsy by Aourz, Najat, Serruys, Ann-Sophie K, Chabwine, Joëlle N, Balegamire, Pascal Byenda, Afrikanova, Tatiana, Edrada-Ebel, RuAngelie, Grey, Alexander I, Kamuhabwa, Appolinary R, Walrave, Laura, Esguerra, Camila V, van Leuven, Fred, de Witte, Peter A. M, Smolders, Ilse, Crawford, Alexander D

“…In view of the clinical need for new antiseizure drugs (ASDs) with novel modes of action, we used a zebrafish seizure model to screen the anticonvulsant…”
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Integration of Microfractionation, qNMR and zebrafish screening for the in vivo bioassay-guided isolation and quantitative bioactivity analysis of natural products by Bohni, Nadine, Cordero-Maldonado, María Lorena, Maes, Jan, Siverio-Mota, Dany, Marcourt, Laurence, Munck, Sebastian, Kamuhabwa, Appolinary R, Moshi, Mainen J, Esguerra, Camila V, de Witte, Peter A M, Crawford, Alexander D, Wolfender, Jean-Luc

“…Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovery. Several challenges nevertheless persist with respect…”
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Cyberlindnera jadinii yeast as a functional protein source: Modulation of immunoregulatory pathways in the intestinal proteome of zebrafish (Danio rerio) by Purushothaman, Kathiresan, Crawford, Alexander D., Rocha, Sérgio D.C., Göksu, Aleksandar B., Lange, Byron Morales, Mydland, Liv Torunn, Vij, Shubha, Qingsong, Lin, Øverland, Margareth, Press, Charles McL

“…Yeasts contain bioactive components that can enhance fish immune robustness and disease resistance. Our study focused on analyzing intestinal immunoregulatory…”
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Effectiveness of add‐on acetazolamide in children with drug‐resistant CHD2‐related epilepsy and in a zebrafish CHD2 model by Melikishvili, Gia, Striano, Pasquale, Shojeinia, Elham, Gachechiladze, Tamar, Kurua, Ekaterine, Tabatadze, Nazhi, Melikishvili, Mariam, Koniashvili, Otar, Khachiashvili, Gvantsa, Epitashvili, Nino, Rimma, Gamirova, Belyaev, Oleg, Tomenko, Tatyana, Kharytonov, Volodymyr, Guliyeva, Ulviyya, Esguerra, Camila V., Crawford, Alexander D., Dulac, Olivier

“…CHD2‐related epilepsy is characterized by early‐onset photosensitive myoclonic epilepsy with developmental delay and a high rate of pharmacoresistance. We…”
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From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin by Copmans, Daniëlle, Kildgaard, Sara, Roux, Emma, Partoens, Michèle, Steurs, Gert, Wang, Xinhui, De Borggraeve, Wim M, Esguerra, Camila V, Crawford, Alexander D, Larsen, Thomas O, de Witte, Peter A M

“…PharmaSea performed large-scale in vivo screening of marine natural product (MNP) extracts, using zebrafish embryos and larvae, to identify compounds with the…”
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