Search Results - "Cravo, Pedro V."

Chalcone Derivatives: Promising Starting Points for Drug Design by Gomes, Marcelo N, Muratov, Eugene N, Pereira, Maristela, Peixoto, Josana C, Rosseto, Lucimar P, Cravo, Pedro V L, Andrade, Carolina H, Neves, Bruno J

“…Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward…”
Get full text

Natural products as leads in schistosome drug discovery by Neves, Bruno J, Andrade, Carolina H, Cravo, Pedro V L

“…Schistosomiasis is a neglected parasitic tropical disease that claims around 200,000 human lives every year. Praziquantel (PZQ), the only drug recommended by…”
Get full text

In silico repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of Schistosoma mansoni by Neves, Bruno J, Braga, Rodolpho C, Bezerra, José C B, Cravo, Pedro V L, Andrade, Carolina H

“…Morbidity and mortality caused by schistosomiasis are serious public health problems in developing countries. Because praziquantel is the only drug in…”
Get full text

Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing by Culleton, Richard L, Mita, Toshihiro, Ndounga, Mathieu, Unger, Holger, Cravo, Pedro V L, Paganotti, Giacomo M, Takahashi, Nobuyuki, Kaneko, Akira, Eto, Hideaki, Tinto, Halidou, Karema, Corine, D'Alessandro, Umberto, do Rosário, Virgilio, Kobayakawa, Takatoshi, Ntoumi, Francine, Carter, Richard, Tanabe, Kazuyuki

“…Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence…”
Get full text

QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities by Lima, Marilia N N, Melo-Filho, Cleber C, Cassiano, Gustavo C, Neves, Bruno J, Alves, Vinicius M, Braga, Rodolpho C, Cravo, Pedro V L, Muratov, Eugene N, Calit, Juliana, Bargieri, Daniel Y, Costa, Fabio T M, Andrade, Carolina H

“…Malaria is a life-threatening infectious disease caused by parasites of the genus , affecting more than 200 million people worldwide every year and leading to…”
Get full text

A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants by Ferreira, Letícia Tiburcio, Cassiano, Gustavo Capatti, Alvarez, Luis Carlos Salazar, Okombo, John, Calit, Juliana, Fontinha, Diana, Gil-Iturbe, Eva, Coyle, Rachael, Andrade, Carolina Horta, Sunnerhagen, Per, Bargieri, Daniel Youssef, Prudêncio, Miguel, Quick, Matthias, Cravo, Pedro V, Lee, Marcus C S, Fidock, David A, Costa, Fabio Trindade Maranhão

“…Artemisinin-based combination therapy (ACT) is the mainstay of effective treatment of Plasmodium falciparum malaria. However, the long-term utility of ACTs is…”
Get full text

Real-time quantitative PCR with SYBR Green I detection for estimating copy numbers of nine drug resistance candidate genes in Plasmodium falciparum by Ferreira, Isabel D, Rosário, Virgílio E do, Cravo, Pedro V L

“…Evaluating copy numbers of given genes in Plasmodium falciparum parasites is of major importance for laboratory-based studies or epidemiological surveys. For…”
Get full text

Genetics of Mefloquine Resistance in the Rodent Malaria Parasite Plasmodium chabaudi by CRAVO, Pedro V. L, CARLTON, Jane M.-R, HUNT, Paul, BISONI, Laura, PADUA, Rose Ann, WALLIKER, David

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Innovative Multistage ML-QSAR Models for Malaria: From Data to Discovery by Borba, Joyce V. B., Salazar-Alvarez, Luis Carlos, Ferreira, Letícia Tiburcio, Silva-Mendonça, Sabrina, Silva, Meryck Felipe Brito da, Sanches, Igor H., Clementino, Leandro da Costa, Magalhães, Marcela Lucas, Rimoldi, Aline, Calit, Juliana, Santana, Sofia, Prudêncio, Miguel, Cravo, Pedro V., Bargieri, Daniel Y., Cassiano, Gustavo C., Costa, Fabio T. M., Andrade, Carolina Horta

“…Malaria presents a significant challenge to global public health, with around 247 million cases estimated to occur annually worldwide. The growing resistance…”
Get full text

An AFLP-based genetic linkage map of Plasmodium chabaudi chabaudi by Martinelli, Axel, Hunt, Paul, Fawcett, Richard, Cravo, Pedro V L, Walliker, David, Carter, Richard

“…Plasmodium chabaudi chabaudi can be considered as a rodent model of human malaria parasites in the genetic analysis of important characters such as drug…”
Get full text

Is there still room to explore cyclodextrin glycosyltransferase-producers in Brazilian biodiversity? by Gomes, Andrea C S M, Santos, Samuel R Dos, Ribeiro, Maycon C, Cravo, Pedro V L, Vieira, José Daniel G, Souza, Keili M C DE, Amaral, Andre C

“…In the present work, different Brazilian biomes aiming to identify and select cyclodextrin glycosyltransferase-producer bacteria are explored. This enzyme is…”
Get full text

Analysis of genetic mutations associated with anti-malarial drug resistance in Plasmodium falciparum from the Democratic Republic of East Timor by de Almeida, Afonso, Arez, Ana Paula, Cravo, Pedro Vl, do Rosário, Virgílio E

“…In response to chloroquine (CQ) resistance, the policy for the first-line treatment of uncomplicated malaria in the Democratic Republic of East Timor (DRET)…”
Get full text

Chloroquine resistance in Plasmodium chabaudi: are chloroquine-resistance transporter ( crt) and multi-drug resistance ( mdr1) orthologues involved? by Hunt, Paul, Cravo, Pedro V.L, Donleavy, Paul, Carlton, Jane M.-R, Walliker, David

“…We have identified in the rodent malaria parasite Plasmodium chabaudi orthologues of two Plasmodium falciparum genes, pfcrt and pfmdr1 which have been…”
Get full text

In Silico Repositioning-Chemogenomics Strategy Identifies New Drugs with Potential Activity against Multiple Life Stages of Schistosoma mansoni: e3435 by Neves, Bruno J, Braga, Rodolpho C, Bezerra, José CB, Cravo, Pedro VL, Andrade, Carolina H

“…Morbidity and mortality caused by schistosomiasis are serious public health problems in developing countries. Because praziquantel is the only drug in…”
Get full text

Of mice and malaria mutants: unravelling the genetics of drug resistance using rodent malaria models by Carlton, Jane M-R., Hayton, Karen, Cravo, Pedro V.L., Walliker, David

“…It is well recognized that drug resistance is the most significant obstacle to gaining effective malaria control. Despite the enormous advances in the…”
Get full text

Plasmodium falciparum: Gene Mutations and Amplification of Dihydrofolate Reductase Genes in Parasites Grown in Vitro in Presence of Pyrimethamine by Thaithong, S., Ranford-Cartwright, L.C., Siripoon, N., Harnyuttanakorn, P., Kanchanakhan, N.S., Seugorn, A., Rungsihirunrat, K., Cravo, P.V.L., Beale, G.H.

“…Thaithong, S., Ranford-Cartwright, L. C., Siripoon, N., Harnyuttanakorn, P., Kanchanakhan, N. S., Seugorn, A., Rungsihirunrat, K., Cravo, P. V. L., and Beale,…”
Get full text

The genetics of resistance to quinoline-containing antimalarials in the rodent malaria parasite plasmodium chabaudi by Cravo, Pedro V. L

“…Some studies on Plasmodium falciparum, the cause of human malaria, have shown a strong association between both mefloquine and quinine resistance and…”
Get full text