Search Results - "Craviotto, Luisa"
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CD14+CD16+ monocytes are involved in daratumumab‐mediated myeloma cells killing and in anti‐CD47 therapeutic strategy
Published in British journal of haematology (01-08-2020)“…Summary A deep elucidation of the mechanisms of action of anti‐CD38 monoclonal antibodies (mAbs), such as daratumumab (DARA), is required to identify patients…”
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2
The Proteasome Inhibitor Bortezomib Maintains Osteocyte Viability in Multiple Myeloma Patients by Reducing Both Apoptosis and Autophagy: A New Function for Proteasome Inhibitors
Published in Journal of bone and mineral research (01-04-2016)“…ABSTRACT Multiple myeloma (MM) is characterized by severely imbalanced bone remodeling. In this study, we investigated the potential effect of proteasome…”
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3
A misleading miscellanea: a COVID-19 patient with fever and cytopenia
Published in Italian journal of medicine (04-11-2024)“…Complex clinical cases characterized by the coexistence of multiple pathologies and, consequently, multiple signs and symptoms shared by various pathological…”
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4
Mechanisms of Action of the New Antibodies in Use in Multiple Myeloma
Published in Frontiers in oncology (08-07-2021)“…Monoclonal antibodies (mAbs) directed against antigen-specific of multiple myeloma (MM) cells have Fc-dependent immune effector mechanisms, such as…”
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5
CD38 expression by plasma cells in extramedullary multiple myeloma
Published in Haematologica (Roma) (01-04-2024)Get full text
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6
The Role of Proteasome Inhibitors in Multiple Myeloma Bone Disease and Bone Metastasis: Effects on Osteoblasts and Osteocytes
Published in Applied sciences (01-05-2021)“…The alterations of bone remodeling are typical of multiple myeloma (MM) patients where the uncoupled and unbalanced bone remodeling caused the onset of…”
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7
Role of 1q21 in Multiple Myeloma: From Pathogenesis to Possible Therapeutic Targets
Published in Cells (Basel, Switzerland) (01-06-2021)“…Multiple myeloma (MM) is characterized by an accumulation of malignant plasma cells (PCs) in the bone marrow (BM). The amplification of 1q21 is one of the most…”
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8
Vacuolated and signet-ring plasma cells in Waldenström macroglobulinemia
Published in International journal of hematology (01-06-2023)Get full text
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9
Neurofibromatosis type I and multiple myeloma coexistence: A possible link?
Published in Hematology reports (03-04-2018)“…The association between Neurofibromatosis type I (NF1) and multiple myeloma (MM), a plasma cell, dyscrasia is very rare. Here we put to the attention of the…”
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10
Haploidentical hematopoietic stem cell transplantation in adults using the αβTCR/CD19-based depletion of G-CSF-mobilized peripheral blood progenitor cells
Published in Bone marrow transplantation (Basingstoke) (01-08-2019)“…In patients with hematological malignancies at high risk for relapse, a mismatched hematopoietic stem cells transplants can be offered with no undue delay…”
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11
The impact of CD56 expression in smoldering myeloma patients on early progression
Published in Hematological oncology (01-08-2023)Get full text
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12
Bone Marrow DKK-1 Levels in Smoldering Multiple Myeloma Patients: A New Independent Risk Factor for Progression
Published in Blood (02-12-2016)“…The presence of bone disease is the hallmark to differentiate patients with active multiple myeloma (MM) from those with smoldering MM (SMM). The diagnostic…”
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13
Bone Marrow Remodelling and Topographic Redistribution of CD34 Positive Progenitors Characterize the Progression of Myelodysplastic Syndromes and Their Evolution to AML
Published in Blood (02-12-2016)“…Myelodysplastic Syndrome (MDS) is a multifaceted disease of Hematopoietic Stem Cells characterized by myeloproliferation associated with mono- or…”
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14
Expression Profile of CD38 and Related Ectoenzymes in Myeloma Bone Niche: A Rational Basis for the Use of Daratumumab to Inhibit Osteoclast Formation and Activity
Published in Blood (03-12-2015)“…The relationship between multiple myeloma (MM) cells and osteoblast (OB)s and osteoclast (OCL)s into the bone marrow (BM) niche has a critical role in the…”
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15
Therapeutic Strategy for Elderly Patients with ACUTE Myeloid Leukemia (AML) Carrying the DNMT3A Mutation
Published in Blood (06-12-2014)“…BACKGROUND: AML in the elderly is associated with low complete remission (CR) rates after induction therapy, poor survival and high treatment-related…”
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16
Protein Kinase C Epsilon Inhibition Restores In-Vitro Megakaryocyte Differentiation Of Primary Myelofibrosis Hematopoietic Progenitors
Published in Blood (15-11-2013)“…Among the three classic Philadelphia-negative myeloproliferative neoplasms (Phneg MPN), myelofibrosis (MF) is the most severe in terms of survival and quality…”
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17
Haploidentical Stem Cell Transplantation After Negative Depletion Of T Cells Expressing The αβ Chain Of The T-Cell Receptor (TCR) For Adults With Hematological Malignancies
Published in Blood (15-11-2013)“…For many years, T cell depletion (TCD) of hematopoietic stem cells (HSCs) has been based on either positive or negative selection of mobilised peripheral blood…”
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18
Relationship Between Presence Of Osteolytic Lesions, Cytogenetic Features and Bone Marrow Levels Of Cytokines and Chemokines In Multiple Myeloma Patients: Role Of Chemokine (C-C motif) Ligand 20
Published in Blood (15-11-2013)“…Osteolytic lesions are the main feature of multiple myeloma (MM) patients. In the last years the pathophysiological role of several cytokines and chemokines…”
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19
Trascriptome Analysis of Bone Marrow CD14+ Monocytes Revealed Differential Expression Profiles in Symptomatic Multiple Myeloma (MM) Compared to Smoldering MM and Monoclonal Gammopathy of Undetermined Significance
Published in Blood (16-11-2012)“…Abstract 1811 Symptomatic multiple myeloma (MM), smoldering MM (SMM) and monoclonal gammopathy of uncertain significance (MGUS) are well known different…”
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Hypoxia and Hypoxia Inducible Factor (HIF)-1α in Multiple Myeloma: Effect on the Pro-Angiogenic Signature of Myeloma Cells and the Bone Marrow Microenvironment
Published in Blood (16-11-2008)“…Hypoxia is a common feature of solid tumors associated to angiogenesis and malignant phenotype. Tumor adaptation to hypoxia is mainly due to the…”
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