Search Results - "Craven, Timothy"

Cyclic Peptide Screening Methods for Preclinical Drug Discovery by Li, Xinting, Craven, Timothy W, Levine, Paul M

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Effects of Intensive BP Control in CKD by Cheung, Alfred K, Rahman, Mahboob, Reboussin, David M, Craven, Timothy E, Greene, Tom, Kimmel, Paul L, Cushman, William C, Hawfield, Amret T, Johnson, Karen C, Lewis, Cora E, Oparil, Suzanne, Rocco, Michael V, Sink, Kaycee M, Whelton, Paul K, Wright, Jr, Jackson T, Basile, Jan, Beddhu, Srinivasan, Bhatt, Udayan, Chang, Tara I, Chertow, Glenn M, Chonchol, Michel, Freedman, Barry I, Haley, William, Ix, Joachim H, Katz, Lois A, Killeen, Anthony A, Papademetriou, Vasilios, Ricardo, Ana C, Servilla, Karen, Wall, Barry, Wolfgram, Dawn, Yee, Jerry

“…The appropriate target for BP in patients with CKD and hypertension remains uncertain. We report prespecified subgroup analyses of outcomes in participants…”
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De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor by Yin, Yizhen, Ochi, Nobuaki, Craven, Timothy W, Baker, David, Takigawa, Nagio, Suga, Hiroaki

“…l-Carboranylalanine (LCba) is a unique artificial amino acid containing a cluster of 10 boron atoms. Since the three-dimensional aromaticity and charge…”
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Comprehensive computational design of ordered peptide macrocycles by Hosseinzadeh, Parisa, Bhardwaj, Gaurav, Mulligan, Vikram Khipple, Shortridge, Matthew D., Craven, Timothy W., Pardo-Avila, Fátima, Rettie, Stephen A., Kim, David E., Silva, Daniel-Adriano, Ibrahim, Yehia M., Webb, Ian K., Cort, John R., Adkins, Joshua N., Varani, Gabriele, Baker, David

“…Mixed-chirality peptide macrocycles such as cyclosporine are among the most potent therapeutics identified to date, but there is currently no way to…”
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Effects of intensive glucose control on microvascular outcomes in patients with type 2 diabetes: a meta-analysis of individual participant data from randomised controlled trials by Zoungas, Sophia, Prof, Arima, Hisatomi, Prof, Gerstein, Hertzel C, Prof, Holman, Rury R, Prof, Woodward, Mark, Prof, Reaven, Peter, Prof, Hayward, Rodney A, Prof, Craven, Timothy, MSPH, Coleman, Ruth L, MSc, Chalmers, John, Prof

“…Summary Background Intensive glucose control is understood to prevent complications in adults with type 2 diabetes. We aimed to more precisely estimate the…”
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The Sulfur-Linked Analogue of O‑GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O‑GlcNAc at the Peptide and Protein Levels by De Leon, Cesar A, Levine, Paul M, Craven, Timothy W, Pratt, Matthew R

“…Synthetic proteins bearing site-specific posttranslational modifications have revolutionized our understanding of their biological functions in vitro and in…”
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O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity by Balana, Aaron T., Levine, Paul M., Craven, Timothy W., Mukherjee, Somnath, Pedowitz, Nichole J., Moon, Stuart P., Takahashi, Terry T., Becker, Christian F. W., Baker, David, Pratt, Matthew R.

“…A major role for the intracellular post-translational modification O-GlcNAc appears to be the inhibition of protein aggregation. Most of the previous studies…”
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Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer by Schneider, Jeffrey A., Craven, Timothy W., Kasper, Amanda C., Yun, Chi, Haugbro, Michael, Briggs, Erica M., Svetlov, Vladimir, Nudler, Evgeny, Knaut, Holger, Bonneau, Richard, Garabedian, Michael J., Kirshenbaum, Kent, Logan, Susan K.

“…New chemical inhibitors of protein–protein interactions are needed to propel advances in molecular pharmacology. Peptoids are peptidomimetic oligomers with the…”
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Effects of Intensive Blood Pressure Lowering on Kidney Tubule Injury in CKD: A Longitudinal Subgroup Analysis in SPRINT by Malhotra, Rakesh, Craven, Timothy, Ambrosius, Walter T., Killeen, Anthony A., Haley, William E., Cheung, Alfred K., Chonchol, Michel, Sarnak, Mark, Parikh, Chirag R., Shlipak, Michael G., Ix, Joachim H.

“…Random assignment to the intensive systolic blood pressure (SBP) arm (<120mmHg) in the Systolic Blood Pressure Intervention Trial (SPRINT) resulted in more…”
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Accurate de novo design of membrane-traversing macrocycles by Bhardwaj, Gaurav, O’Connor, Jacob, Rettie, Stephen, Huang, Yen-Hua, Ramelot, Theresa A., Mulligan, Vikram Khipple, Alpkilic, Gizem Gokce, Palmer, Jonathan, Bera, Asim K., Bick, Matthew J., Di Piazza, Maddalena, Li, Xinting, Hosseinzadeh, Parisa, Craven, Timothy W., Tejero, Roberto, Lauko, Anna, Choi, Ryan, Glynn, Calina, Dong, Linlin, Griffin, Robert, van Voorhis, Wesley C., Rodriguez, Jose, Stewart, Lance, Montelione, Gaetano T., Craik, David, Baker, David

“…We use computational design coupled with experimental characterization to systematically investigate the design principles for macrocycle membrane permeability…”
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Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites by Hosseinzadeh, Parisa, Watson, Paris R., Craven, Timothy W., Li, Xinting, Rettie, Stephen, Pardo-Avila, Fátima, Bera, Asim K., Mulligan, Vikram Khipple, Lu, Peilong, Ford, Alexander S., Weitzner, Brian D., Stewart, Lance J., Moyer, Adam P., Di Piazza, Maddalena, Whalen, Joshua G., Greisen, Per Jr, Christianson, David W., Baker, David

“…Despite recent success in computational design of structured cyclic peptides, de novo design of cyclic peptides that bind to any protein functional site…”
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Grip strength measurement for frailty assessment in patients with vascular disease and associations with comorbidity, cardiac risk, and sarcopenia by Reeve, Thomas E., Ur, Rebecca, Craven, Timothy E., Kaan, James H., Goldman, Matthew P., Edwards, Matthew S., Hurie, Justin B., Velazquez-Ramirez, Gabriela, Corriere, Matthew A.

“…Frailty is associated with adverse events, length of stay, and nonhome discharge after vascular surgery. Frailty measures based on walking-based tests may be…”
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Kidney Damage Biomarkers and Incident Chronic Kidney Disease During Blood Pressure Reduction: A Case-Control Study by Zhang, William R, Craven, Timothy E, Malhotra, Rakesh, Cheung, Alfred K, Chonchol, Michel, Drawz, Paul, Sarnak, Mark J, Parikh, Chirag R, Shlipak, Michael G, Ix, Joachim H

“…Whether the increased incidence of chronic kidney disease (CKD) during intensive systolic blood pressure (SBP) lowering is accompanied by intrinsic kidney…”
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Effect of Intensive Glycemic Control on Risk of Lower Extremity Amputation by Goldman, Matthew P., Clark, Christopher J., Craven, Timothy E., Davis, Ross P., Williams, Timothy K., Velazquez-Ramirez, Gabriela, Hurie, Justin B., Edwards, Matthew S.

“…Diabetes mellitus is a major risk factor for peripheral arterial disease and lower extremity amputation (LEA). We evaluated the effects of intensive glucose…”
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Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1 by Mulligan, Vikram Khipple, Workman, Sean, Sun, Tianjun, Rettie, Stephen, Li, Xinting, Worrall, Liam J., Craven, Timothy W., King, Dustin T., Hosseinzadeh, Parisa, Watkins, Andrew M., Renfrew, P. Douglas, Guffy, Sharon, Labonte, Jason W., Moretti, Rocco, Bonneau, Richard, Strynadka, Natalie C. J., Baker, David

“…The rise of antibiotic resistance calls for new therapeutics targeting resistance factors such as the New Delhi metallo-β-lactamase 1 (NDM-1), a bacterial…”
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PPII Helical Peptidomimetics Templated by Cation-π Interactions by Craven, Timothy W., Bonneau, Richard, Kirshenbaum, Kent

“…Poly‐proline type II (PPII) helical PXXP motifs are the recognition elements for a variety of protein–protein interactions that are critical for cellular…”
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A Miniature Protein Stabilized by a Cation−π Interaction Network by Craven, Timothy W, Cho, Min-Kyu, Traaseth, Nathaniel J, Bonneau, Richard, Kirshenbaum, Kent

“…The design of folded miniature proteins is predicated on establishing noncovalent interactions that direct the self-assembly of discrete thermostable tertiary…”
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Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor by Muratspahić, Edin, Deibler, Kristine, Han, Jianming, Tomašević, Nataša, Jadhav, Kirtikumar B., Olivé-Marti, Aina-Leonor, Hochrainer, Nadine, Hellinger, Roland, Koehbach, Johannes, Fay, Jonathan F., Rahman, Mohammad Homaidur, Hegazy, Lamees, Craven, Timothy W., Varga, Balazs R., Bhardwaj, Gaurav, Appourchaux, Kevin, Majumdar, Susruta, Muttenthaler, Markus, Hosseinzadeh, Parisa, Craik, David J., Spetea, Mariana, Che, Tao, Baker, David, Gruber, Christian W.

“…Despite the increasing number of GPCR structures and recent advances in peptide design, the development of efficient technologies allowing rational design of…”
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Effects of Intensive Systolic Blood Pressure Control on Kidney and Cardiovascular Outcomes in Persons Without Kidney Disease: A Secondary Analysis of a Randomized Trial by Beddhu, Srinivasan, Rocco, Michael V, Toto, Robert, Craven, Timothy E, Greene, Tom, Bhatt, Udayan, Cheung, Alfred K, Cohen, Debbie, Freedman, Barry I, Hawfield, Amret T, Killeen, Anthony A, Kimmel, Paul L, Lash, James, Papademetriou, Vasilios, Rahman, Mahboob, Rastogi, Anjay, Servilla, Karen, Townsend, Raymond R, Wall, Barry, Whelton, Paul K

“…The public health significance of the reported higher incidence of chronic kidney disease (CKD) with intensive systolic blood pressure (SBP) lowering is…”
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Isolating Conformers to Assess Dynamics of Peptidic Catalysts Using Computationally Designed Macrocyclic Peptides by Stone, Elizabeth A, Hosseinzadeh, Parisa, Craven, Timothy W, Robertson, Michael J, Han, Yaodong, Hsieh, Sheng-Ying, Metrano, Anthony J, Baker, David, Miller, Scott J

“…Studying the relationship between catalyst conformational dynamics and selectivity in an asymmetric reaction is a challenge. In this study, cyclic peptides…”
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