Search Results - "Craven, Brent A."

Credibility assessment of in silico clinical trials for medical devices by Pathmanathan, Pras, Aycock, Kenneth, Badal, Andreu, Bighamian, Ramin, Bodner, Jeff, Craven, Brent A, Niederer, Steven

“…In silico clinical trials (ISCTs) are an emerging method in modeling and simulation where medical interventions are evaluated using computational models of…”
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The fluid dynamics of canine olfaction: unique nasal airflow patterns as an explanation of macrosmia by Craven, Brent A., Paterson, Eric G., Settles, Gary S.

“…The canine nasal cavity contains hundreds of millions of sensory neurons, located in the olfactory epithelium that lines convoluted nasal turbinates recessed…”
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A schlieren optical study of the human cough with and without wearing masks for aerosol infection control by Tang, Julian W., Liebner, Thomas J., Craven, Brent A., Settles, Gary S.

“…Various infectious agents are known to be transmitted naturally via respiratory aerosols produced by infected patients. Such aerosols may be produced during…”
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The Influence of Sniffing on Airflow and Odorant Deposition in the Canine Nasal Cavity by Rygg, Alex D, Van Valkenburgh, Blaire, Craven, Brent A

“…Nasal airflow plays a critical role in olfaction by transporting odorant from the environment to the olfactory epithelium, where chemical detection occurs…”
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New insight into the evolution of the vertebrate respiratory system and the discovery of unidirectional airflow in iguana lungs by Cleri, Robert L., Craven, Brent A., Schachner, Emma R., Farmer, C. G.

“…Significance The avian respiratory system appears strikingly distinct from all other animals. Purported key innovations underpinning avian patterns of airflow…”
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Tour of a Labyrinth: Exploring the Vertebrate Nose by Valkenburgh, Blaire, Smith, Timothy D., Craven, Brent A.

“…ABSTRACT This special issue of The Anatomical Record is the outcome of a symposium entitled “Inside the Vertebrate Nose: Evolution, Structure and Function.”…”
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Mechanistic modeling of generic orally inhaled drug products: A workshop summary report by Walenga, Ross L., Butler, Clare, Craven, Brent A., Longest, P. Worth, Mohamed, Raja, Newman, Bryan, Olsson, Bo, Hochhaus, Günther, Li, Bing V., Luke, Markham C., Zhao, Liang, Przekwas, Andrzej, Lionberger, Robert

“…In silico mechanistic modeling approaches have been designed by various stakeholders with the goal of supporting development and approval of generic orally…”
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Toward trustworthy medical device in silico clinical trials: a hierarchical framework for establishing credibility and strategies for overcoming key challenges by Aycock, Kenneth I, Battisti, Tom, Peterson, Ashley, Yao, Jiang, Kreuzer, Steven, Capelli, Claudio, Pant, Sanjay, Pathmanathan, Pras, Hoganson, David M, Levine, Steve M, Craven, Brent A

“…Computational models of patients and medical devices can be combined to perform an clinical trial (ISCT) to investigate questions related to device safety…”
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Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation by Bhardwaj, Saurabh, Craven, Brent A, Sever, Jacob E, Costanzo, Francesco, Simon, Scott D, Manning, Keefe B

“…Acute ischemic stroke (AIS) is a leading cause of mortality that occurs when an embolus becomes lodged in the cerebral vasculature and obstructs blood flow in…”
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In vitro quantification of time dependent thrombus size using magnetic resonance imaging and computational simulations of thrombus surface shear stresses by Taylor, Joshua O, Witmer, Kory P, Neuberger, Thomas, Craven, Brent A, Meyer, Richard S, Deutsch, Steven, Manning, Keefe B

“…Thrombosis and thromboembolization remain large obstacles in the design of cardiovascular devices. In this study, the temporal behavior of thrombus size within…”
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Tests of the chromatographic theory of olfaction with highly soluble odors: a combined electro-olfactogram and computational fluid dynamics study in the mouse by Coppola, David M, Fitzwater, Emily, Rygg, Alex D, Craven, Brent A

“…The idea that the vertebrate nasal cavity operates like a gas chromatograph to separate and discriminate odors, referred to herein as the ‘chromatographic…”
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Nasal Morphometry in Marmosets: Loss and Redistribution of Olfactory Surface Area by Smith, Timothy D., Eiting, Thomas P., Bonar, Christopher J., Craven, Brent A.

“…ABSTRACT The two major groups of primates differ in internal nasal anatomy. Strepsirrhines (e.g., lemurs) have more numerous turbinals and recesses compared…”
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A computational study of the hydrodynamics in the nasal region of a hammerhead shark (Sphyrna tudes): implications for olfaction by Rygg, Alex D, Cox, Jonathan P L, Abel, Richard, Webb, Andrew G, Smith, Nadine B, Craven, Brent A

“…The hammerhead shark possesses a unique head morphology that is thought to facilitate enhanced olfactory performance. The olfactory chambers, located at the…”
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Reconstruction and Morphometric Analysis of the Nasal Airway of the Dog (Canis familiaris) and Implications Regarding Olfactory Airflow by Craven, Brent A., Neuberger, Thomas, Paterson, Eric G., Webb, Andrew G., Josephson, Eleanor M., Morrison, Edward E., Settles, Gary S.

“…The canine nasal airway is an impressively complex anatomical structure, having many functional roles. The complicated branching and intricate scrollwork of…”
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Molecular dynamics simulations of water/mucus partition coefficients for feeding stimulants in fish and the implications for olfaction by Rygg, Alex D, van Duin, Adri C T, Craven, Brent A

“…The odorant partition coefficient is a physicochemical property that has been shown to dramatically influence odorant deposition patterns in the mammalian…”
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An immersed interface method for discrete surfaces by Kolahdouz, Ebrahim M., Bhalla, Amneet Pal Singh, Craven, Brent A., Griffith, Boyce E.

“…Fluid-structure systems occur in a range of scientific and engineering applications. The immersed boundary (IB) method is a widely recognized and effective…”
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Examining the universality of the hemolysis power law model from simulations of the FDA nozzle using calibrated model coefficients by Mantegazza, Alberto, Tobin, Nicolas, Manning, Keefe B., Craven, Brent A.

“…Computational fluid dynamics (CFD) is widely used to predict mechanical hemolysis in medical devices. The most popular hemolysis model is the stress-based…”
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Fluid–Structure Interaction Models of Bioprosthetic Heart Valve Dynamics in an Experimental Pulse Duplicator by Lee, Jae H., Rygg, Alex D., Kolahdouz, Ebrahim M., Rossi, Simone, Retta, Stephen M., Duraiswamy, Nandini, Scotten, Lawrence N., Craven, Brent A., Griffith, Boyce E.

“…Computer modeling and simulation is a powerful tool for assessing the performance of medical devices such as bioprosthetic heart valves (BHVs) that promises to…”
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Three‐Dimensional Structure of the Nasal Passageway of a Hagfish and its Implications for Olfaction by Holmes, William M., Cotton, Ross, Xuan, Viet Bui, Rygg, Alex D., Craven, Brent A., Abel, Richard L., Slack, Robert, Cox, Jonathan P.L.

“…From high‐resolution (65 μm) data acquired by magnetic resonance imaging, we have reconstructed the nasal passageway of a single adult hagfish specimen…”
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Method of manufactured solutions code verification of elastostatic solid mechanics problems in a commercial finite element solver by Aycock, Kenneth I., Rebelo, Nuno, Craven, Brent A.

“…•Examples of rigorous code verification for solid mechanics are rare in literature.•Verification evidence is especially lacking for nonlinear analyses and…”
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