Search Results - "Crary, John F."

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions by Baleriola, Jimena, Walker, Chandler A., Jean, Ying Y., Crary, John F., Troy, Carol M., Nagy, Peter L., Hengst, Ulrich

“…In Alzheimer’s disease (AD) brain, exposure of axons to Aβ causes pathogenic changes that spread retrogradely by unknown mechanisms, affecting the entire…”
Get full text

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy by McKee, Ann C., Cairns, Nigel J., Dickson, Dennis W., Folkerth, Rebecca D., Dirk Keene, C., Litvan, Irene, Perl, Daniel P., Stein, Thor D., Vonsattel, Jean-Paul, Stewart, William, Tripodis, Yorghos, Crary, John F., Bieniek, Kevin F., Dams-O’Connor, Kristen, Alvarez, Victor E., Gordon, Wayne A.

“…Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain…”
Get full text

High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development by Hefti, Marco M, Farrell, Kurt, Kim, SoongHo, Bowles, Kathryn R, Fowkes, Mary E, Raj, Towfique, Crary, John F

“…The microtubule associated protein tau plays a critical role in the pathogenesis of neurodegenerative disease. Recent studies suggest that tau also plays a…”
Get full text

Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression by Aubry, Soline, Shin, William, Crary, John F, Lefort, Roger, Qureshi, Yasir H, Lefebvre, Celine, Califano, Andrea, Shelanski, Michael L

“…Alzheimer's disease (AD) is a complex multifactorial disorder with poorly characterized pathogenesis. Our understanding of this disease would thus benefit from…”
Get full text

Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau by Santa-Maria, Ismael, Alaniz, Maria E, Renwick, Neil, Cela, Carolina, Fulga, Tudor A, Van Vactor, David, Tuschl, Thomas, Clark, Lorraine N, Shelanski, Michael L, McCabe, Brian D, Crary, John F

“…Tau is a highly abundant and multifunctional brain protein that accumulates in neurofibrillary tangles (NFTs), most commonly in Alzheimer's disease (AD) and…”
Get full text

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids by Bowles, Kathryn R., Silva, M. Catarina, Whitney, Kristen, Bertucci, Taylor, Berlind, Joshua E., Lai, Jesse D., Garza, Jacob C., Boles, Nathan C., Mahali, Sidhartha, Strang, Kevin H., Marsh, Jacob A., Chen, Cynthia, Pugh, Derian A., Liu, Yiyuan, Gordon, Ronald E., Goderie, Susan K., Chowdhury, Rebecca, Lotz, Steven, Lane, Keith, Crary, John F., Haggarty, Stephen J., Karch, Celeste M., Ichida, Justin K., Goate, Alison M., Temple, Sally

“…Frontotemporal dementia (FTD) because of MAPT mutation causes pathological accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms…”
Get full text

Cognitive trajectory in mild cognitive impairment due to primary age-related tauopathy by Teylan, Merilee, Mock, Charles, Gauthreaux, Kathryn, Chen, Yen-Chi, Chan, Kwun C G, Hassenstab, Jason, Besser, Lilah M, Kukull, Walter A, Crary, John F

“…Primary age-related tauopathy is increasingly recognized as a separate neuropathological entity different from Alzheimer's disease. Both share the…”
Get full text

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease by Wang, Minghui, Roussos, Panos, McKenzie, Andrew, Zhou, Xianxiao, Kajiwara, Yuji, Brennand, Kristen J, De Luca, Gabriele C, Crary, John F, Casaccia, Patrizia, Buxbaum, Joseph D, Ehrlich, Michelle, Gandy, Sam, Goate, Alison, Katsel, Pavel, Schadt, Eric, Haroutunian, Vahram, Zhang, Bin

“…Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite…”
Get full text

Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19 by Fullard, John F, Lee, Hao-Chih, Voloudakis, Georgios, Suo, Shengbao, Javidfar, Behnam, Shao, Zhiping, Peter, Cyril, Zhang, Wen, Jiang, Shan, Corvelo, André, Wargnier, Heather, Woodoff-Leith, Emma, Purohit, Dushyant P, Ahuja, Sadhna, Tsankova, Nadejda M, Jette, Nathalie, Hoffman, Gabriel E, Akbarian, Schahram, Fowkes, Mary, Crary, John F, Yuan, Guo-Cheng, Roussos, Panos

“…Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has been associated with neurological…”
Get full text

Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease model by Morrone Parfitt, Gustavo, Coccia, Elena, Goldman, Camille, Whitney, Kristen, Reyes, Ricardo, Sarrafha, Lily, Nam, Ki Hong, Sohail, Soha, Jones, Drew R., Crary, John F., Ordureau, Alban, Blanchard, Joel, Ahfeldt, Tim

“…Accumulation of advanced glycation end products (AGEs) on biopolymers accompanies cellular aging and drives poorly understood disease processes. Here, we…”
Get full text

Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors by Sproul, Andrew A, Jacob, Samson, Pre, Deborah, Kim, Soong Ho, Nestor, Michael W, Navarro-Sobrino, Miriam, Santa-Maria, Ismael, Zimmer, Matthew, Aubry, Soline, Steele, John W, Kahler, David J, Dranovsky, Alex, Arancio, Ottavio, Crary, John F, Gandy, Sam, Noggle, Scott A

“…Presenilin 1 (PSEN1) encodes the catalytic subunit of γ-secretase, and PSEN1 mutations are the most common cause of early onset familial Alzheimer's disease…”
Get full text

ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin by Sun, Xiaotian, Liu, Jin, Crary, John F, Malagelada, Cristina, Sulzer, David, Greene, Lloyd A, Levy, Oren A

“…Parkinson's disease (PD) is a common neurodegenerative disorder, for which there are no effective disease-modifying therapies. The transcription factor ATF4…”
Get full text

Researching COVID to enhance recovery (RECOVER) tissue pathology study protocol: Rationale, objectives, and design by Troxel, Andrea B, Bind, Marie-Abele C, Flotte, Thomas J, Cordon-Cardo, Carlos, Decker, Lauren A, Finn, Aloke V, Padera, Robert F, Reichard, R Ross, Stone, James R, Adolphi, Natalie L, Casimero, Faye Victoria C, Crary, John F, Elifritz, Jamie, Faustin, Arline, Ghosh, Saikat Kumar B, Krausert, Amanda, Martinez-Lage, Maria, Melamed, Jonathan, Mitchell, Jr, Roger A, Sampson, Barbara A, Seifert, Alan C, Simsir, Aylin, Adams, Cheryle, Haasnoot, Stephanie, Hafner, Stephanie, Siciliano, Michelle A, Vallejos, Brittany B, Del Boccio, Phoebe, Lamendola-Essel, Michelle F, Young, Chloe E, Kewlani, Deepshikha, Akinbo, Precious A, Parent, Brendan, Chung, Alicia, Cato, Teresa C, Mudumbi, Praveen C, Esquenazi-Karonika, Shari, Wood, Marion J, Chan, James, Monteiro, Jonathan, Shinnick, Daniel J, Thaweethai, Tanayott, Nguyen, Amber N, Fitzgerald, Megan L, Perlowski, Alice A, Stiles, Lauren E, Paskett, Moira L, Katz, Stuart D, Foulkes, Andrea S

“…SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of…”
Get full text

Author Correction: Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes by Farrell, Kurt, Humphrey, Jack, Chang, Timothy, Zhao, Yi, Leung, Yuk Yee, Kuksa, Pavel P., Patil, Vishakha, Lee, Wan-Ping, Kuzma, Amanda B., Valladares, Otto, Cantwell, Laura B., Wang, Hui, Ravi, Ashvin, De Sanctis, Claudia, Han, Natalia, Christie, Thomas D., Afzal, Robina, Kandoi, Shrishtee, Whitney, Kristen, Krassner, Margaret M., Ressler, Hadley, Kim, SoongHo, Dangoor, Diana, Iida, Megan A., Casella, Alicia, Walker, Ruth H., Nirenberg, Melissa J., Renton, Alan E., Babrowicz, Bergan, Coppola, Giovanni, Raj, Towfique, Höglinger, Günter U., Müller, Ulrich, Golbe, Lawrence I., Morris, Huw R., Hardy, John, Revesz, Tamas, Warner, Tom T., Jaunmuktane, Zane, Mok, Kin Y., Rademakers, Rosa, Dickson, Dennis W., Ross, Owen A., Wang, Li-San, Goate, Alison, Schellenberg, Gerard, Geschwind, Daniel H., Crary, John F., Naj, Adam

Get full text

Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes by Farrell, Kurt, Humphrey, Jack, Chang, Timothy, Zhao, Yi, Leung, Yuk Yee, Kuksa, Pavel P., Patil, Vishakha, Lee, Wan-Ping, Kuzma, Amanda B., Valladares, Otto, Cantwell, Laura B., Wang, Hui, Ravi, Ashvin, De Sanctis, Claudia, Han, Natalia, Christie, Thomas D., Afzal, Robina, Kandoi, Shrishtee, Whitney, Kristen, Krassner, Margaret M., Ressler, Hadley, Kim, SoongHo, Dangoor, Diana, Iida, Megan A., Casella, Alicia, Walker, Ruth H., Nirenberg, Melissa J., Renton, Alan E., Babrowicz, Bergan, Coppola, Giovanni, Raj, Towfique, Höglinger, Günter U., Müller, Ulrich, Golbe, Lawrence I., Morris, Huw R., Hardy, John, Revesz, Tamas, Warner, Tom T., Jaunmuktane, Zane, Mok, Kin Y., Rademakers, Rosa, Dickson, Dennis W., Ross, Owen A., Wang, Li-San, Goate, Alison, Schellenberg, Gerard, Geschwind, Daniel H., Crary, John F., Naj, Adam

“…Progressive supranuclear palsy (PSP), a rare Parkinsonian disorder, is characterized by problems with movement, balance, and cognition. PSP differs from…”
Get full text

Multiple sclerosis in LRRK2 G2019S Parkinson's disease and isolated nigral degeneration in a homozygous variant carrier by Wise, Adina, Ortega, Roberto A, Raymond, Deborah, Cervera, Alessandra, Thorn, Emma, Leaver, Katherine, Russell, David S, Bressman, Susan B, Crary, John F, Saunders-Pullman, Rachel

“…variants have been associated with immune dysregulation as well as immune-related disorders such as IBD. A possible relationship between multiple sclerosis…”
Get full text

Perfusion fixation in brain banking: a systematic review by McFadden, Whitney C, Walsh, Hadley, Richter, Felix, Soudant, Céline, Bryce, Clare H, Hof, Patrick R, Fowkes, Mary, Crary, John F, McKenzie, Andrew T

“…Perfusing fixatives through the cerebrovascular system is the gold standard approach in animals to prepare brain tissue for spatial biomolecular profiling,…”
Get full text

Immunohistochemical Method and Histopathology Judging for the Systemic Synuclein Sampling Study (S4) by Beach, Thomas G, Serrano, Geidy E, Kremer, Thomas, Canamero, Marta, Dziadek, Sebastian, Sade, Hadassah, Derkinderen, Pascal, Corbillé, Anne-Gaëlle, Letournel, Franck, Munoz, David G, White, Charles L, Schneider, Julie, Crary, John F, Sue, Lucia I, Adler, Charles H, Glass, Michael J, Intorcia, Anthony J, Walker, Jessica E, Foroud, Tatiana, Coffey, Christopher S, Ecklund, Dixie, Riss, Holly, Goßmann, Jennifer, König, Fatima, Kopil, Catherine M, Arnedo, Vanessa, Riley, Lindsey, Linder, Carly, Dave, Kuldip D, Jennings, Danna, Seibyl, John, Mollenhauer, Brit, Chahine, Lana

“…Abstract Immunohistochemical (IHC) α-synuclein (Asyn) pathology in peripheral biopsies may be a biomarker of Parkinson disease (PD). The multi-center Systemic…”
Get full text

Neuroimmune proteins can differentiate between tauopathies by Cherry, Jonathan D, Baucom, Zach H, Eppich, Kaleb G, Kirsch, Daniel, Dixon, Erin R, Tripodis, Yorghos, Bieniek, Kevin F, Farrell, Kurt, Whitney, Kristen, Uretsky, Madeline, Crary, John F, Dickson, Dennis, McKee, Ann C

“…Tauopathies are a group of neurodegenerative diseases where there is pathologic accumulation of hyperphosphorylated tau protein (ptau). The most common…”
Get full text

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes by Bowles, Kathryn R, Pugh, Derian A, Liu, Yiyuan, Patel, Tulsi, Renton, Alan E, Bandres-Ciga, Sara, Gan-Or, Ziv, Heutink, Peter, Siitonen, Ari, Bertelsen, Sarah, Cherry, Jonathan D, Karch, Celeste M, Frucht, Steven J, Kopell, Brian H, Peter, Inga, Park, Y J, Charney, Alexander, Raj, Towfique, Crary, John F, Goate, A M

“…Parkinson's disease (PD) is genetically associated with the H1 haplotype of the MAPT 17q.21.31 locus, although the causal gene and variants underlying this…”
Get full text