Search Results - "Crapser, Joshua D"

To Kill a Microglia: A Case for CSF1R Inhibitors by Green, Kim N., Crapser, Joshua D., Hohsfield, Lindsay A.

“…Microglia, the brain’s immune sentinels, have garnered much attention in recent years. Researchers have begun to identify the manifold roles that these cells…”
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Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease by Crapser, Joshua D, Ochaba, Joseph, Soni, Neelakshi, Reidling, Jack C, Thompson, Leslie M, Green, Kim N

“…Huntington's disease is associated with a reactive microglial response and consequent inflammation. To address the role of these cells in disease pathogenesis,…”
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Microglia as hackers of the matrix: sculpting synapses and the extracellular space by Crapser, Joshua D., Arreola, Miguel A., Tsourmas, Kate I., Green, Kim N.

“…Microglia shape the synaptic environment in health and disease, but synapses do not exist in a vacuum. Instead, pre- and postsynaptic terminals are surrounded…”
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Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain by Crapser, Joshua D., Spangenberg, Elizabeth E., Barahona, Rocio A., Arreola, Miguel A., Hohsfield, Lindsay A., Green, Kim N.

“…Microglia, the brain's principal immune cell, are increasingly implicated in Alzheimer's disease (AD), but the molecular interfaces through which these cells…”
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Aging alters the immunological response to ischemic stroke by Ritzel, Rodney M., Lai, Yun-Ju, Crapser, Joshua D., Patel, Anita R., Schrecengost, Anna, Grenier, Jeremy M., Mancini, Nickolas S., Patrizz, Anthony, Jellison, Evan R., Morales-Scheihing, Diego, Venna, Venugopal R., Kofler, Julia K., Liu, Fudong, Verma, Rajkumar, McCullough, Louise D.

“…The peripheral immune system plays a critical role in aging and in the response to brain injury. Emerging data suggest inflammatory responses are exacerbated…”
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Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R +/- mouse model of ALSP, which can be rescued via CSF1R inhibitors by Arreola, Miguel A, Soni, Neelakshi, Crapser, Joshua D, Hohsfield, Lindsay A, Elmore, Monica R P, Matheos, Dina P, Wood, Marcelo A, Swarup, Vivek, Mortazavi, Ali, Green, Kim N

“…Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is an autosomal dominant neurodegenerative disease caused by mutations in…”
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Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave by Hohsfield, Lindsay A, Najafi, Allison R, Ghorbanian, Yasamine, Soni, Neelakshi, Crapser, Joshua, Figueroa Velez, Dario X, Jiang, Shan, Royer, Sarah E, Kim, Sung Jin, Henningfield, Caden M, Anderson, Aileen, Gandhi, Sunil P, Mortazavi, Ali, Inlay, Matthew A, Green, Kim N

“…Microglia, the brain’s resident myeloid cells, play central roles in brain defense, homeostasis, and disease. Using a prolonged colony-stimulating factor 1…”
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Abstract TMP35: CD200-CD200R1 Inhibitory Signaling Attenuates Neuroinflammation and Reduces Behavioral Deficits Following Ischemic Stroke by Ritzel, Rodney M, Mamun, Abdullah A, Crapser, Joshua D, Verma, Rajkumar, Patel, Anita R, Knight, Brittany E, Harris, Nia M, Mancini, Nickolas S, Liu, Fudong, McCullough, Louise D

“…Abstract only Introduction: In ischemic stroke, central nervous system homeostasis is dysregulated, leading to a significant inflammatory response, cell death,…”
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