A consensus view of the proteome of the last universal common ancestor

A consensus view of the proteome of the last universal common ancestor

The availability of genomic and proteomic data from across the tree of life has made it possible to infer features of the genome and proteome of the last universal common ancestor (LUCA). A number of studies have done so, all using a unique set of methods and bioinformatics databases. Here, we compa...

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Bibliographic Details
Published in:Ecology and evolution Vol. 12; no. 6; pp. e8930 - n/a
Main Authors: Crapitto, Andrew J., Campbell, Amy, Harris, AJ, Goldman, Aaron D.
Format: Journal Article
Language:English
Published: England John Wiley & Sons, Inc 01-07-2022
John Wiley and Sons Inc
Wiley
Subjects:
Amino acids
ancient genomes
ancient life
ancient metabolism
Biochemistry
Bioinformatics
Cofactors
early evolution
Genealogy
Genes
Genomes
last universal common ancestor
LUCA
LUCA protein
Metabolism
Nucleotides
Organisms
Phylogenetics
Predictions
Protein biosynthesis
Protein synthesis
Protein turnover
Proteins
Proteomes
Proteomics
ancient metabolism
last universal common ancestor
ancient genomes
early evolution
LUCA
ancient life
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Summary:The availability of genomic and proteomic data from across the tree of life has made it possible to infer features of the genome and proteome of the last universal common ancestor (LUCA). A number of studies have done so, all using a unique set of methods and bioinformatics databases. Here, we compare predictions across eight such studies and measure both their agreement with one another and with the consensus predictions among them. We find that some LUCA genome studies show a strong agreement with the consensus predictions of the others, but that no individual study shares a high or even moderate degree of similarity with any other individual study. From these observations, we conclude that the consensus among studies provides a more accurate depiction of the core proteome of the LUCA and its functional repertoire. The set of consensus LUCA protein family predictions between all of these studies portrays a LUCA genome that, at minimum, encoded functions related to protein synthesis, amino acid metabolism, nucleotide metabolism, and the use of common, nucleotide‐derived organic cofactors. Over the past couple of decades, researchers have used genomic data from organisms across the tree of life to infer the characteristics of the last universal common ancestor, an organism or community of organisms that lived roughly 3.5–4 billion years ago. Here, we compare predictions between previously published studies of the genome and proteome of the last universal common ancestor, measuring their agreement and identifying consensus between them.
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ISSN:2045-7758
2045-7758
DOI:10.1002/ece3.8930