Search Results - "Cramer, Sarah D"

Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis by Keifer, Orion P, Gutierrez, Juanmarco, Butt, Mark T, Cramer, Sarah D, Bartus, Raymond, Tansey, Malu, Deaver, Daniel, Betourne, Alexandre, Boulis, Nicholas M

“…Riluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclerosis (ALS). However, oral riluzole efficacy is modest at…”
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Scientific and Regulatory Policy Committee Points to Consider for Medical Device Implant Site Evaluation in Nonclinical Studies by O’Brien, Maureen T., Schuh, JoAnn C. L., Wancket, Lyn M., Cramer, Sarah D., Funk, Kathleen A., Jackson, Nicolette D., Kannan, Kamala, Keane, Kevin, Nyska, Abraham, Rousselle, Serge D., Schucker, Adrienne, Thomas, Valerie S., Tunev, Stefan

“…Nonclinical implantation studies are a common and often critical step for medical device safety assessment in the bench-to-market pathway. Nonclinical…”
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Pseudorabies virus infection in Oklahoma hunting dogs by Cramer, Sarah D, Campbell, Gregory A, Njaa, Bradley L, Morgan, Sandra E, Smith, Stephen K. II, McLin, William R. IV, Brodersen, Bruce W, Wise, Annabel G, Scherba, Gail, Langohr, Ingeborg M, Maes, Roger K

“…Pseudorabies is caused by Suid herpesvirus 1, a member of the Alphaherpesvirinae subfamily. Although pigs are the natural host of Pseudorabies virus (PRV), the…”
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Agreement in Histological Assessment of Mitotic Activity Between Microscopy and Digital Whole Slide Images Informs Conversion for Clinical Diagnosis by Wei, Bih-Rong, Halsey, Charles H., Hoover, Shelley B., Puri, Munish, Yang, Howard H., Gallas, Brandon D., Lee, Maxwell P., Chen, Weijie, Durham, Amy C., Dwyer, Jennifer E., Sánchez, Melissa D., Traslavina, Ryan P., Frank, Chad, Bradley, Charles, McGill, Lawrence D., Esplin, D. Glen, Schaffer, Paula A., Cramer, Sarah D., Lyle, L. Tiffany, Beck, Jessica, Buza, Elizabeth, Gong, Qi, Hewitt, Stephen M., Simpson, R. Mark

“…Validating digital pathology as substitute for conventional microscopy in diagnosis remains a priority to assure effectiveness. Intermodality concordance…”
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Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment by Cramer, Sarah D., Aplan, Peter D., Durum, Scott K.

“…Increased understanding of pediatric acute lymphoblastic leukemia (ALL) pathobiology has led to dramatic improvements in patient survival. However, there is…”
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Automated Computational Detection, Quantitation, and Mapping of Mitosis in Whole-Slide Images for Clinically Actionable Surgical Pathology Decision Support by Puri, Munish, Hoover, Shelley B., Hewitt, Stephen M., Wei, Bih-Rong, Adissu, Hibret Amare, Halsey, Charles H.C., Beck, Jessica, Bradley, Charles, Cramer, Sarah D., Durham, Amy C., Esplin, D. Glen, Frank, Chad, Lyle, L. Tiffany, McGill, Lawrence D., Sánchez, Melissa D., Schaffer, Paula A., Traslavina, Ryan P., Buza, Elizabeth, Yang, Howard H., Lee, Maxwell P., Dwyer, Jennifer E., Simpson, R. Mark

“…Background: Determining mitotic index by counting mitotic figures (MFs) microscopically from tumor areas with most abundant MF (hotspots [HS]) produces a…”
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Plasticity in early immune evasion strategies of a bacterial pathogen by Bernard, Quentin, Smith, Alexis A., Yang, Xiuli, Koci, Juraj, Foor, Shelby D., Cramer, Sarah D., Zhuang, Xuran, Dwyer, Jennifer E., Lin, Yi-Pin, Mongodin, Emmanuel F., Marques, Adriana, Leong, John M., Anguita, Juan, Pal, Utpal

“…Borrelia burgdorferi is one of the few extracellular pathogens capable of establishing persistent infection in mammals. The mechanisms that sustain long-term…”
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Toxicologic Neuropathology of Novel Biotherapeutics by Bangari, Dinesh S., Lanigan, Lisa G., Cramer, Sarah D., Grieves, Jessica L., Meisner, René, Rogers, Arlin B., Galbreath, Elizabeth J., Bolon, Brad

“…Biotherapeutic modalities such as cell therapies, gene therapies, nucleic acids, and proteins are increasingly investigated as disease-modifying treatments for…”
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Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems: New and Revised INHAND Terms by Bradley, Alys E., Bolon, Brad, Butt, Mark T., Cramer, Sarah D., Czasch, Stephanie, Garman, Robert H., George, Catherine, Gröters, Sibylle, Kaufmann, Wolfgang, Kovi, Ramesh C., Krinke, Georg, Little, Peter B., Narama, Isao, Rao, Deepa B., Sharma, Alok K., Shibutani, Makoto, Sills, Robert

“…Harmonization of diagnostic terminology used during the histopathologic analysis of rodent tissue sections from nonclinical toxicity studies will improve the…”
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Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing by Bennet, Bindu M., Pardo, Ingrid D., Assaf, Basel T., Buza, Elizabeth, Cramer, Sarah D., Crawford, LaTasha K., Engelhardt, Jeffery A., Galbreath, Elizabeth J., Grubor, Branka, Morrison, James P., Osborne, Tanasa S., Sharma, Alok K., Bolon, Brad

“…Dorsal root ganglia (DRG), trigeminal ganglia (TG), other sensory ganglia, and autonomic ganglia may be injured by some test article classes, including…”
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Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations by Senkevitch, Emilee, Li, Wenqing, Hixon, Julie A, Andrews, Caroline, Cramer, Sarah D, Pauly, Gary T, Back, Timothy, Czarra, Kelli, Durum, Scott K

“…Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Current chemotherapy is quite toxic in growing children and more directed…”
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Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia by Cramer, Sarah D., Hixon, Julie A., Andrews, Caroline, Porter, Ross J., Rodrigues, Gisele O. L., Wu, Xiaolin, Back, Tim, Czarra, Kelli, Michael, Helen, Cam, Maggie, Chen, Jack, Esposito, Dominic, Senkevitch, Emilee, Negi, Vijay, Aplan, Peter D., Li, Wenqing, Durum, Scott K.

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Neurologic Medical Device Overview for Pathologists by Cramer, Sarah D., Lee, Juliana S., Butt, Mark T., Paulin, Jaime, Stoffregen, William C.

“…Thorough morphologic evaluations of medical devices placed in or near the nervous system depend on many factors. Pathologists interpreting a neurologic device…”
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Co-Culture and Transduction of Murine Thymocytes on Delta-Like 4-Expressing Stromal Cells to Study Oncogenes in T-Cell Leukemia by Rodrigues, Gisele O L, Li, WenQing, Cramer, Sarah D, Winer, Hila Y, Hsu, Tu Chun, Gower, Timothy, Hixon, Julie A, Durum, Scott K

“…Transduced mouse immature thymocytes can be differentiated into T cells in vitro using the delta-like 4-expressing bone marrow stromal cell line co-culture…”
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Mutations that collaborate with IL-7Ra signaling pathways to drive ALL by Rodrigues, Gisele O.L., Cramer, Sarah D., Winer, Hila Y., Hixon, Julie A., Li, WenQing, Yunes, José Andres, Durum, Scott K.

“…The IL-7 pathway is required for normal T cell development and survival. In recent years the pathway has been shown to be a major driver of acute lymphoblastic…”
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Sellar Xanthogranuloma in a Dog by Cramer, Sarah D., Miller, Andrew D., Medici, Emily L., Brunker, Jill D., Ritchey, Jerry W.

“…A 7-year-old, intact male standard Poodle dog with hypothyroidism and atypical hyperadrenocorticism developed acute signs of lethargy, weakness, inappetence,…”
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Clinical snapshot: Colitis in a paint gelding by Cramer, Sarah D, Love, Brenda, Ritchey, Jerry W, Banse, Heidi

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Pathology in practice. Brain neoplasm by Cramer, Sarah D, Campbell, Gregory A, Gray, Charles W, Lamm, Catherine G

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Mutant IL-7R[alpha] and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia by Cramer, Sarah D, Hixon, Julie A, Andrews, Caroline, Porter, Ross J, Rodrigues, Gisele O. L, Wu, Xiaolin, Back, Tim

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Pathology in practice. Squamous cell carcinoma of the penis with multifocal metastasis to the regional lymph nodes, lungs, and heart by Cramer, Sarah D, Breshears, Melanie A, Qualls, Heath J

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