Search Results - "Crair, Michael C."

Architecture, Function, and Assembly of the Mouse Visual System by Seabrook, Tania A, Burbridge, Timothy J, Crair, Michael C, Huberman, Andrew D

“…Vision is the sense humans rely on most to navigate the world, make decisions, and perform complex tasks. Understanding how humans see thus represents one of…”
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Retinal waves coordinate patterned activity throughout the developing visual system by Ackman, James B., Burbridge, Timothy J., Crair, Michael C.

“…The morphological and functional development of the vertebrate nervous system is initially governed by genetic factors and subsequently refined by neuronal…”
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Retinal waves prime visual motion detection by simulating future optic flow by Ge, Xinxin, Zhang, Kathy, Gribizis, Alexandra, Hamodi, Ali S, Sabino, Aude Martinez, Crair, Michael C

“…The ability to perceive and respond to environmental stimuli emerges in the absence of sensory experience. Spontaneous retinal activity prior to eye opening…”
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Homeostatic Control of Spontaneous Activity in the Developing Auditory System by Babola, Travis A., Li, Sally, Gribizis, Alexandra, Lee, Brian J., Issa, John B., Wang, Han Chin, Crair, Michael C., Bergles, Dwight E.

“…Neurons in the developing auditory system exhibit spontaneous bursts of activity before hearing onset. How this intrinsically generated activity influences…”
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Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits by Barson, Daniel, Hamodi, Ali S., Shen, Xilin, Lur, Gyorgy, Constable, R. Todd, Cardin, Jessica A., Crair, Michael C., Higley, Michael J.

“…Spontaneous and sensory-evoked activity propagates across varying spatial scales in the mammalian cortex, but technical challenges have limited conceptual…”
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Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas by Yao, Kai, Qiu, Suo, Wang, Yanbin V., Park, Silvia J. H., Mohns, Ethan J., Mehta, Bhupesh, Liu, Xinran, Chang, Bo, Zenisek, David, Crair, Michael C., Demb, Jonathan B., Chen, Bo

“…In zebrafish, Müller glia (MG) are a source of retinal stem cells that can replenish damaged retinal neurons and restore vision 1 . In mammals, however, MG do…”
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Reconnecting Eye to Brain by Crair, Michael C, Mason, Carol A

“…Although much is known about the regenerative capacity of retinal ganglion cells, very significant barriers remain in our ability to restore visual function…”
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Preservation of vision after CaMKII-mediated protection of retinal ganglion cells by Guo, Xinzheng, Zhou, Jing, Starr, Christopher, Mohns, Ethan J., Li, Yidong, Chen, Earnest P., Yoon, Yonejung, Kellner, Christopher P., Tanaka, Kohichi, Wang, Hongbing, Liu, Wei, Pasquale, Louis R., Demb, Jonathan B., Crair, Michael C., Chen, Bo

“…Retinal ganglion cells (RGCs) are the sole output neurons that transmit visual information from the retina to the brain. Diverse insults and pathological…”
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Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission by Li, Hong, Fertuzinhos, Sofia, Mohns, Ethan, Hnasko, Thomas S., Verhage, Matthijs, Edwards, Robert, Sestan, Nenad, Crair, Michael C.

“…A dynamic interplay between intrinsic regional molecular cues and extrinsic factors from the thalamus shape multiple features of early cortical development. It…”
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Synapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1 by Ribic, Adema, Crair, Michael C., Biederer, Thomas

“…Cortical plasticity peaks early in life and tapers in adulthood, as exemplified in the primary visual cortex (V1), wherein brief loss of vision in one eye…”
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Visual circuit development requires patterned activity mediated by retinal acetylcholine receptors by Burbridge, Timothy J, Xu, Hong-Ping, Ackman, James B, Ge, Xinxin, Zhang, Yueyi, Ye, Mei-Jun, Zhou, Z Jimmy, Xu, Jian, Contractor, Anis, Crair, Michael C

“…The elaboration of nascent synaptic connections into highly ordered neural circuits is an integral feature of the developing vertebrate nervous system. In…”
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An Instructive Role for Patterned Spontaneous Retinal Activity in Mouse Visual Map Development by Xu, Hong-ping, Furman, Moran, Mineur, Yann S., Chen, Hui, King, Sarah L., Zenisek, David, Zhou, Z. Jimmy, Butts, Daniel A., Tian, Ning, Picciotto, Marina R., Crair, Michael C.

“…Complex neural circuits in the mammalian brain develop through a combination of genetic instruction and activity-dependent refinement. The relative role of…”
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Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization by Vafaii, Hadi, Mandino, Francesca, Desrosiers-Grégoire, Gabriel, O’Connor, David, Markicevic, Marija, Shen, Xilin, Ge, Xinxin, Herman, Peter, Hyder, Fahmeed, Papademetris, Xenophon, Chakravarty, Mallar, Crair, Michael C., Constable, R. Todd, Lake, Evelyn M. R., Pessoa, Luiz

“…Large-scale functional networks have been characterized in both rodent and human brains, typically by analyzing fMRI-BOLD signals. However, the relationship…”
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How do barrels form in somatosensory cortex? by Li, Hong, Crair, Michael C.

“…The somatosensory cortex of many rodents, lagomorphs, and marsupials contains distinct cytoarchitectonic features named “barrels” that reflect the pattern of…”
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Transverse sinus injections drive robust whole-brain expression of transgenes by Hamodi, Ali S, Martinez Sabino, Aude, Fitzgerald, N Dalton, Moschou, Dionysia, Crair, Michael C

“…Convenient, efficient and fast whole-brain delivery of transgenes presents a persistent experimental challenge in neuroscience. Recent advances demonstrate…”
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Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1 by Ribic, Adema, Liu, Xinran, Crair, Michael C., Biederer, Thomas

“…ABSTRACT Adhesive interactions in the retina instruct the developmental specification of inner retinal layers. However, potential roles of adhesion in the…”
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Development of Cortical Maps: Perspectives From the Barrel Cortex by Inan, Melis, Crair, Michael C.

“…One approach to examining how higher sensory, motor, and cognitive faculties emerge in the neocortex is to elucidate the underlying wiring principles of the…”
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Development of single retinofugal axon arbors in normal and β2 knock-out mice by Dhande, Onkar S, Hua, Ethan W, Guh, Emily, Yeh, Jonathan, Bhatt, Shivani, Zhang, Yueyi, Ruthazer, Edward S, Feller, Marla B, Crair, Michael C

“…The maturation of retinal ganglion cell (RGC) axon projections in the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC) relies on both…”
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Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits by Xu, Hong-Ping, Burbridge, Timothy J, Ye, Meijun, Chen, Minggang, Ge, Xinxin, Zhou, Z Jimmy, Crair, Michael C

“…Retinal waves are correlated bursts of spontaneous activity whose spatiotemporal patterns are critical for early activity-dependent circuit elaboration and…”
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Synapse maturation is enhanced in the binocular region of the retinocollicular map prior to eye opening by Furman, Moran, Crair, Michael C

“…In the developing visual system of mammals, retinal axons from the two eyes compete for postsynaptic partners. After eye opening, this process is regulated in…”
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