Search Results - "Craig, Sandra"

Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE by Craig, Sandra N., Baxter, Merissa, Chapagai, Danda, Stafford, Jessy M., Nurmemmedov, Elmar, Altomare, Diego, Wyatt, Michael D., McInnes, Campbell

“…Polo-like kinase 1 (PLK1) is a serine/threonine-protein kinase involved in cell cycle regulation and mitotic progression. Studies have shown that PLK1 is…”
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Synthesis and evaluation of aryl boronic acids as fluorescent artificial receptors for biological carbohydrates by Craig, Sandra

“…[Display omitted] ▸ Aryl boronic acid compounds serving as artificial receptors for biological carbohydrates. ▸ Boronic acid rapidly and reversibly bind to 1,2…”
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Current assessment of polo-like kinases as anti-tumor drug targets by Craig, Sandra N, Wyatt, Michael D, McInnes, Campbell

“…Polo-like kinase (PLK)1 is the most studied of the PLK family and is a serine/threonine kinase that plays pivotal roles in many aspects of mitosis and hence…”
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Benzamide capped peptidomimetics as non-ATP competitive inhibitors of CDK2 using the REPLACE strategy by Premnath, Padmavathy Nandha, Craig, Sandra N., Liu, Shu, McInnes, Campbell

“…[Display omitted] Inhibition of cyclin dependent kinase 2 (CDK2) in complex with cyclin A in G1/S phase of the cell cycle has been shown to promote selective…”
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Iterative Conversion of Cyclin Binding Groove Peptides into Druglike CDK Inhibitors with Antitumor Activity by Premnath, Padmavathy Nandha, Craig, Sandra N., Liu, Shu, Anderson, Erin L., Grigoroudis, Asterios I., Kontopidis, George, Perkins, Tracy L., Wyatt, Michael D., Pittman, Douglas L., McInnes, Campbell

“…The cyclin groove is an important recognition site for substrates of the cell cycle cyclin dependent kinases and provides an opportunity for highly selective…”
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Abstract 1241: Converting high affinity peptides to non-peptidic inhibitors via REPLACE: Novel and new strategies in targeting PLK1 Polo Box Domain (PBD) for anti-cancer therapy by Chapagai, Danda, Ramamoorthy, Guru, Baxter, Merissa, Craig, Sandra, Nurmemmedov, Elmar, Campbell, McInnes, Wyatt, Michael

“…Polo Like Kinase 1 (PLK1) is only expressed in dividing cells and plays a critical role in several stages of mitosis. PLK1 is highly expressed in tumors of…”
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Peptidomimetic Polo‐Box‐Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor by Baxter, Merissa, Chapagai, Danda, Craig, Sandra, Hurtado, Cecilia, Varghese, Jessy, Nurmemmedov, Elmar, Wyatt, Michael D., McInnes, Campbell

“…The polo‐box domain (PBD) of PLK1 determines mitotic substrate recognition and subcellular localization. Compounds that target PLK1 selectively are required…”
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Gold-Containing Indoles as Anticancer Agents That Potentiate the Cytotoxic Effects of Ionizing Radiation by Craig, Sandra, Gao, Lei, Lee, Irene, Gray, Thomas, Berdis, Anthony J

“…This report describes the design and application of several distinct gold-containing indoles as anticancer agents. When used individually, all gold-bearing…”
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Abstract 4574: Polo box-targeted PLK1 inhibitors: structure activity relationships and activity in cells resistant to ATP-based inhibitors by Baxer, Merissa, Craig, Sandra, McInnes, Campbell, Wyatt, Michael

“…Polo-like Kinase 1 (PLK1) performs critical roles in the coordination of mitosis. PLK1 is also an oncogene over-expressed in many cancer types and is being…”
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors by Nandha Premnath, Padmavathy, Craig, Sandra, McInnes, Campbell

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Abstract 2572: A novel strategy for PLK1 kinase inhibition by allosterically targeting the Polo Box Domain by Chapagai, Danda, Baxter, Merissa, Craig, Sandra, Ramamoorthy, Guru, Stafford, Jessy, Vitali, Sikirzhytski, Nurmemmedov, Elmar, McInnes, Campbell, Wyatt, Michael D.

“…Polo Like Kinase 1 (PLK1) is only expressed in dividing cells and plays a critical role in several stages of mitosis. PLK1 is overexpressed in many tumor…”
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Abstract 2156: Targeting polo-like kinase 1 with novel inhibitors of the polo-box domain by Baxter, Merissa, Craig, Sandra, McInnes, Campbell, Wyatt, Michael D.

“…Polo-like Kinase 1 (PLK1) is a central player in cell cycle regulation and mitotic progression. Observations that PLK1 is over-expressed in many cancer types…”
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors by Nandha Premnath, Padmavathy, Craig, Sandra, McInnes, Campbell

“…REPLACE is a unique strategy developed to more effectively target protein-protein interactions (PPIs). It aims to expand available drug target space by…”
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Expression and genomic structure of the genes encoding FdI, the major allergen from the domestic cat by Griffith, I J, Craig, S, Pollock, J, Yu, X B, Morgenstern, J P, Rogers, B L

“…The genes encoding chain 1 (Ch1) and chain 2 (Ch2) of the major allergen of the domestic cat, Felis domesticus I, have been analyzed by genomic cloning and by…”
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Abstract 4609: Agenus’ next generation cancer vaccine platforms by Uduman, Mohamed, Khattar, Mithun, Joshi, Bishnu, Tanne, Antoine, Morin, Benjamin, Karapetyan, Armen, Drouin, Elise, Craig, Sandra, Myers, Paisley, Jeffery, Erin, Wilson, Nicholas, Yang, Amy, Engelhard, Victor H., Cobbold, Mark, Hunt, Donald F., Underwood, Dennis, Lin, Shiwen, Findeis, Mark, Raizer, Jeffrey, Goldberg, John, Buell, Jennifer S., Stein, Robert, Levey, Daniel L., Castle, John

“…Most cancer cells carry mutations unique to the patient’s individual tumor and shared biochemical signatures that are not present in healthy cells. Agenus has…”
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Gold-Containing Indoles as Anti-Cancer Agents that Potentiate the Cytotoxic Effects of Ionizing Radiation by Craig, Sandra, Gao, Lei, Lee, Irene, Gray, Thomas, Berdis, Anthony J.

“…This report describes the design and application of several distinct gold-containing indoles as anti-cancer agents. When used individually, all gold-bearing…”
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A polymeric peroxo heteroligand vanadate(V). Synthesis, spectra, and structure of MI[VO(O2)(C4H5O4N)] by Djordjevic, Cirila, Craig, Sandra A, Sinn, Ekk

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Active-Site-Directed Chemical Tools for Profiling Mitochondrial Lon Protease by Fishovitz, Jennifer, Li, Min, Frase, Hilary, Hudak, Jason, Craig, Sandra, Ko, Kristin, Berdis, Anthony J, Suzuki, Carolyn K, Lee, Irene

“…Lon and ClpXP are the only soluble ATP-dependent proteases within the mammalian mitochondria matrix, which function in protein quality control by selectively…”
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Emergency department management of patients with automatic implantable cardioverter-defibrillators by Craig, S A, Hudson, A D

“…The case of a patient with idiopathic dilated cardiomyopathy and complex ventricular arrhythmias who underwent placement of an automatic implantable…”
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Patients with Alcohol Problems in the Emergency Department, Part 1: Improving Detection by D'Onofrio, Gail, Bernstein, Edward, Bernstein, Judith, Woolard, Robert H., Brewer, Phillip A., Craig, Sandra A., Zink, Brian J.

“… Medical and social problems related to alcohol use are frequently seen in the ED. Often, the tempo of emergency medicine practice seems to preclude…”
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