Search Results - "Cragg, Gordon M"

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019 by Newman, David J, Cragg, Gordon M

“…This review is an updated and expanded version of the five prior reviews that were published in this journal in 1997, 2003, 2007, 2012, and 2016. For all…”
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Natural Products as Sources of New Drugs from 1981 to 2014 by Newman, David J, Cragg, Gordon M

“…This contribution is a completely updated and expanded version of the four prior analogous reviews that were published in this journal in 1997, 2003, 2007, and…”
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Natural products: A continuing source of novel drug leads by Cragg, Gordon M., Newman, David J.

“…Nature has been a source of medicinal products for millennia, with many useful drugs developed from plant sources. Following discovery of the penicillins, drug…”
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Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents by Cragg, Gordon M., Pezzuto, John M.

“…Throughout history, natural products have played a dominant role in the treatment of human ailments. For example, the legendary discovery of penicillin…”
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Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010 by Newman, David J, Cragg, Gordon M

“…This review is an updated and expanded version of the three prior reviews that were published in this journal in 1997, 2003, and 2007. In the case of all…”
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Impact of Natural Products on Developing New Anti-Cancer Agents by Cragg, Gordon M, Grothaus, Paul G, Newman, David J

“…A discussion of naturally-occurring biochemicals which may have promise in developing new anti-cancer drugs is presented. How such bioproducts attack cancer…”
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Natural Products as Sources of New Drugs over the Last 25 Years by Newman, David J, Cragg, Gordon M

“…This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003. In the case of all approved agents…”
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Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development by Newman, David J, Cragg, Gordon M

“…The marine habitat has produced a significant number of very potent marine-derived agents that have the potential to inhibit the growth of human tumor cells in…”
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Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates by Newman, David J, Cragg, Gordon M

“…In this review, we have attempted to describe all of the antibody-drug conjugates using a marine-derived compound as the "warhead", that are currently in…”
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Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials by Newman, David J, Cragg, Gordon M

“…The marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in antitumor,…”
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Endophytic and epiphytic microbes as "sources" of bioactive agents by Newman, David J, Cragg, Gordon M

“…Beginning with the report by Stierle and Strobel in 1993 on taxol((R)) production by an endophytic fungus (Stierle et al., 1993), it is possible that a number…”
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Natural Products as Sources of New Drugs over the Period 1981−2002 by Newman, David J, Cragg, Gordon M, Snader, Kenneth M

“…This review is an updated and expanded version of a paper that was published in this journal in 1997. The time frame has been extended in both directions to…”
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The impact of the United Nations Convention on Biological Diversity on natural products research by Cragg, Gordon M, Katz, Flora, Newman, David J, Rosenthal, Joshua

“…The discovery and development of novel, biologically active agents from natural sources, whether they be drugs, agrochemicals or other bioactive entities,…”
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Biodiversity: A continuing source of novel drug leads by Cragg, Gordon M., Newman, David J.

“…Nature has been a source of medicinal agents for thousands of years and continues to be an abundant source of novel chemotypes and pharmacophores. With only 5…”
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Natural product scaffolds as leads to drugs by Newman, David J, Cragg, Gordon M

“…Numerous 'scaffolds' that have been identified in natural product structures have led to very significant numbers of approved drugs and drug candidates for a…”
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A Tale of Two Tumor Targets:  Topoisomerase I and Tubulin. The Wall and Wani Contribution to Cancer Chemotherapy by Cragg, Gordon M, Newman, David J

“…The seminal discoveries of camptothecin and Taxol by Wall and Wani are discussed in a manner that demonstrates the influence that these two compounds has had…”
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Advanced preclinical and clinical trials of natural products and related compounds from marine sources by Newman, David J, Cragg, Gordon M

“…The marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in anti-tumor,…”
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Antineoplastic Agents. 551. Isolation and Structures of Bauhiniastatins 1-4 from Bauhinia purpurea by Pettit, G.R, Numata, A, Iwamoto, C, Usami, Y, Yamada, T, Ohishi, H, Cragg, G.M

“…Bioassay-guided (P388 lymphocytic leukemia cell line) separation of extracts prepared from the leaves, stems, and pods of Bauhinia purpurea, and, in parallel,…”
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New Horizons for Old Drugs and Drug Leads by Cragg, Gordon M, Grothaus, Paul G, Newman, David J

“…There is mounting urgency to find new drugs for the treatment of serious infectious diseases and cancer that are rapidly developing resistance to previously…”
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Drugs and Drug Candidates from Marine Sources: An Assessment of the Current "State of Play" by Newman, David J, Cragg, Gordon M

“…The potential of the marine environment to produce candidate compounds (structures) as leads to, or even direct drugs from, has been actively discussed for the…”
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