Search Results - "Craft, J. Carl"

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria by Charman, Susan A., Arbe-Barnes, Sarah, Bathurst, Ian C., Brun, Reto, Campbell, Michael, Charman, William N., Chiu, Francis C. K., Chollet, Jacques, Craft, J. Carl, Creek, Darren J., Dong, Yuxiang, Matile, Hugues, Maurer, Melanie, Morizzi, Julia, Nguyen, Tien, Papastogiannidis, Petros, Scheurer, Christian, Shackleford, David M., Sriraghavan, Kamaraj, Stingelin, Lukas, Tang, Yuanqing, Urwyler, Heinrich, Wang, Xiaofang, White, Karen L., Wittlin, Sergio, Zhou, Lin, Vennerstrom, Jonathan L., Wellems, Thomas E.

“…Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase…”
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Randomized, Double-Blind, Multicenter Phase 2 Study Comparing the Efficacy and Safety of Oral Solithromycin (CEM-101) to Those of Oral Levofloxacin in the Treatment of Patients with Community-Acquired Bacterial Pneumonia by OLDACH, David, CLARK, Kay, SCHRANZ, Jennifer, DAS, Anita, CRAFT, J. Carl, SCOTT, Drusilla, JAMIESON, Brian D, FERNANDES, Prabhavathi

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Safety and efficacy of pyronaridine-artesunate in uncomplicated acute malaria: an integrated analysis of individual patient data from six randomized clinical trials by Duparc, Stephan, Borghini-Fuhrer, Isabelle, Craft, Carl J, Arbe-Barnes, Sarah, Miller, Robert M, Shin, Chang-Sik, Fleckenstein, Lawrence

“…Pyronaridine-artesunate (PA) is indicated for the treatment of acute uncomplicated Plasmodium falciparum and Plasmodium vivax malaria. Individual patient data…”
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In Vitro and In Vivo Activity of Solithromycin (CEM-101) against Plasmodium Species by WITTLIN, Sergio, EKLAND, Eric, CARL CRAFT, J, LOTHARIUS, Julie, BATHURST, Ian, FIDOCK, David A, FERNANDES, Prabhavathi

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A Randomized, Double-Blind Phase 2 Study Comparing the Efficacy and Safety of an Oral Fusidic Acid Loading-Dose Regimen to Oral Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections by Craft, J. Carl, Moriarty, Susan R., Clark, Kay, Scott, Drusilla, Degenhardt, Thorsten P., Still, J. Gordon, Corey, G. Ralph, Das, Anita, Fernandes, Prabhavathi

“…Fusidic acid (CEM-102), an orally bioavailable fusidane antibiotic with a unique mode of action, is under development for treatment of acute gram-positive…”
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Phase 3 trial of treating gonorrhoea with solithromycin by Fernandes, Prabhavathi, Craft, J Carl

“…In two large phase 3 trials in which multiple doses of solithromycin were tested, increases of alanine transaminase were uncommon, and those that occurred were…”
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Mycoplasma pneumoniae and Chlamydia pneumoniae in pediatric community-acquired pneumonia: comparative efficacy and safety of clarithromycin vs. erythromycin ethylsuccinate by Block, S, Hedrick, J, Hammerschlag, M R, Cassell, G H, Craft, J C

“…We evaluated 260 previously healthy children ages 3 through 12 years who had clinical signs and symptoms of pneumonia, radiographically confirmed. Patients…”
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Challenges facing drug development for malaria by Craft, J Carl

“…Malaria is a significant cause of morbidity and mortality in the developing world. Until recently malaria was winning but with increase in funding particularly…”
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First‐in‐man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials by Moehrle, Joerg J., Duparc, Stephan, Siethoff, Christoph, Giersbergen, Paul L. M., Craft, J. Carl, Arbe‐Barnes, Sarah, Charman, Susan A., Gutierrez, Maria, Wittlin, Sergio, Vennerstrom, Jonathan L.

“…Aims To assess the safety and pharmacokinetics of a new synthetic ozonide antimalarial, OZ439, in a first‐in‐man, double‐blind study in healthy volunteers…”
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Review of pyronaridine anti-malarial properties and product characteristics by Croft, Simon L, Duparc, Stephan, Arbe-Barnes, Sarah J, Craft, J Carl, Shin, Chang-Sik, Fleckenstein, Lawrence, Borghini-Fuhrer, Isabelle, Rim, Han-Jong

“…Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria…”
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Macrolide Therapy of Group A Streptococcal Pharyngitis: 10 Days of Macrolide Therapy (Clarithromycin) Is More Effective in Streptococcal Eradication than 5 Days (Azithromycin) by Kaplan, Edward L., Gooch, W. Manfred, Notario, Gerard F., Craft, J. Carl

“…We compared recommended doses of 2 oral macrolide antibiotics (10 days of clarithromycin, 5 days of azithromycin) for eradicating group A streptococci from the…”
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Comparative embryotoxicity of different antimalarial peroxides: In vitro study using the rat whole embryo culture model (WEC) by Longo, Monica, Zanoncelli, Sara, Brughera, Marco, Colombo, Paolo, Wittlin, Sergio, Vennerstrom, Jonathan L., Moehrle, Joerg, Craft, J. Carl

“…Three groups of compounds: (i) active peroxides (artemisinin and arterolene), (ii) inactive non-peroxidic derivatives (deoxyartemisinin and carbaOZ277) and…”
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Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects by Tan, Beesan, Naik, Himanshu, Jang, In-Jin, Yu, Kyung-Sang, Kirsch, Lee E, Shin, Chang-Sik, Craft, J Carl, Fleckenstein, Lawrence

“…The population pharmacokinetics of artesunate (AS) and its active metabolite dihydroartemisinin (DHA) were studied in healthy subjects receiving single- or…”
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Clarithromycin Resistance and Susceptibility Patterns of Mycobacterium avium Strains Isolated During Prophylaxis for Disseminated Infection in Patients with AIDS by Craft, J Carl, Notario, Gerard F., Grosset, Jacques H., Heifets, Leonid B.

“…A randomized, placebo-controlled trial was conducted to evaluate the efficacy of clarithromycin in the prevention of disseminated Mycobacterium avium complex…”
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A Randomized Trial of Clarithromycin as Prophylaxis against Disseminated Mycobacterium avium Complex Infection in Patients with Advanced Acquired Immunodeficiency Syndrome by Pierce, Mark, Crampton, Sheri, Henry, David, Heifets, Leonid, LaMarca, Anthony, Montecalvo, Marisa, Wormser, Gary P, Jablonowski, Helmut, Jemsek, Joseph, Cynamon, Michael, Yangco, Bienvenido G, Notario, Gerard, Craft, J Carl

“…Disseminated infection with Mycobacterium avium complex is the most common systemic bacterial infection in advanced stages of the acquired immunodeficiency…”
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Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease in patients with HIV infection by CHAISSON, R. E, KEISER, P, PIERCE, M, FESSEL, W. J, RUSKIN, J, LAHART, C, BENSON, C. A, MEEK, K, SIEPMAN, N, CRAFT, J. C

“…To compare the efficacy of two- and three-drug regimens for treating Mycobacterium avium complex (MAC) bacteremia in patients with AIDS. Randomized open-label…”
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Medicines for Malaria Venture new developments in antimalarials by Nwaka, Solomon, Riopel, Lise, Ubben, David, Craft, J.Carl

“…Choosing appropriate chemoprophylaxis and stand-by treatment for travelers will remain a problem for the near future because of resistant Plasmodium…”
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Ketolide ABT-773 is active against Toxoplasma gondii by Khan, Anis A., Araujo, Fausto G., Craft, J. Carl, Remington, Jack S.

“…ABT-773 is active in vitro and in vivo against Toxoplasma gondii. It inhibited replication of RH strain tachyzoites in human foreskin fibroblasts. Mice…”
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Steady-State Pharmacokinetics and Electrocardiographic Pharmacodynamics of Clarithromycin and Loratadine after Individual or Concomitant Administration by CARR, R. A, EDMONDS, A, SHI, H, LOCKE, C. S, GUSTAVSON, L. E, CRAFT, J. C, HARRIS, S. I, PALMER, R

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Overview of the tolerability profile of clarithromycin in preclinical and clinical trials by GUAY, D. R. P, PATTERSON, D. R, SEIPMAN, N, CRAFT, J. C

“…Results of studies conducted to characterise local, systemic, reproductive, and mutagenic effects indicate that the new macrolide antimicrobial clarithromycin…”
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