Search Results - "Craddock, Travis J A"

Short-term sleep deprivation leads to decreased systemic redox metabolites and altered epigenetic status by Trivedi, Malav S, Holger, Dana, Bui, Anh Tuyet, Craddock, Travis J A, Tartar, Jaime L

“…Sleep is critical for repair as well as the rejuvenation processes in the body and many of these functions are regulated via underlying cellular metabolic…”
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The zinc dyshomeostasis hypothesis of Alzheimer's disease by Craddock, Travis J A, Tuszynski, Jack A, Chopra, Deepak, Casey, Noel, Goldstein, Lee E, Hameroff, Stuart R, Tanzi, Rudolph E

“…Alzheimer's disease (AD) is the most common form of dementia in the elderly. Hallmark AD neuropathology includes extracellular amyloid plaques composed largely…”
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A molecular analysis of substituted phenylethylamines as potential microtubule targeting agents through in silico methods and in vitro microtubule-polymerization activity by De Abreu, Isadora Rocha, Barkdull, Allison, Munoz, James R., Smith, Robert P., Craddock, Travis J. A.

“…Natural phenethylamines are trace amine neurotransmitters associated with dopamine transmission and related illnesses such Parkinson’s disease, and addiction…”
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The potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome by Huitsing, Kaylin, Tritsch, Tara, Arias, Francisco Javier Carrera, Collado, Fanny, Aenlle, Kristina K, Nathason, Lubov, Fletcher, Mary Ann, Klimas, Nancy G, Craddock, Travis J A

“…Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the most common…”
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Cytoskeletal signaling: is memory encoded in microtubule lattices by CaMKII phosphorylation? by Craddock, Travis J A, Tuszynski, Jack A, Hameroff, Stuart

“…Memory is attributed to strengthened synaptic connections among particular brain neurons, yet synaptic membrane components are transient, whereas memories can…”
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A role for homeostatic drive in the perpetuation of complex chronic illness: Gulf War Illness and chronic fatigue syndrome by Craddock, Travis J A, Fritsch, Paul, Rice, Jr, Mark A, del Rosario, Ryan M, Miller, Diane B, Fletcher, Mary Ann, Klimas, Nancy G, Broderick, Gordon

“…A key component in the body's stress response, the hypothalamic-pituitary-adrenal (HPA) axis orchestrates changes across a broad range of major biological…”
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Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesia by Craddock, Travis J A, St George, Marc, Freedman, Holly, Barakat, Khaled H, Damaraju, Sambasivarao, Hameroff, Stuart, Tuszynski, Jack A

“…The cytoskeleton is essential to cell morphology, cargo trafficking, and cell division. As the neuronal cytoskeleton is extremely complex, it is no wonder that…”
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Disentangling the effects of PTSD from Gulf War Illness in male veterans via a systems-wide analysis of immune cell, cytokine, and symptom measures by Sultana, Esha, Shastry, Nandan, Kasarla, Rishabh, Hardy, Jacob, Collado, Fanny, Aenlle, Kristina, Abreu, Maria, Sisson, Emily, Sullivan, Kimberly, Klimas, Nancy, Craddock, Travis J A

“…One-third of veterans returning from the 1990-1991 Gulf War reported a myriad of symptoms including cognitive dysfunction, skin rashes, musculoskeletal…”
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Achieving Remission in Gulf War Illness: A Simulation-Based Approach to Treatment Design by Craddock, Travis J A, Del Rosario, Ryan R, Rice, Mark, Zysman, Joel P, Fletcher, Mary Ann, Klimas, Nancy G, Broderick, Gordon

“…Gulf War Illness (GWI) is a chronic multi-symptom disorder affecting up to one-third of the 700,000 returning veterans of the 1991 Persian Gulf War and for…”
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Electronic Energy Migration in Microtubules by Kalra, Aarat P., Benny, Alfy, Travis, Sophie M., Zizzi, Eric A., Morales-Sanchez, Austin, Oblinsky, Daniel G., Craddock, Travis J. A., Hameroff, Stuart R., MacIver, M. Bruce, Tuszyński, Jack A., Petry, Sabine, Penrose, Roger, Scholes, Gregory D.

“…The repeating arrangement of tubulin dimers confers great mechanical strength to microtubules, which are used as scaffolds for intracellular macromolecular…”
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Bio-ModelChecker: Using Bounded Constraint Satisfaction to Seamlessly Integrate Observed Behavior With Prior Knowledge of Biological Networks by Sedghamiz, Hooman, Morris, Matthew, Craddock, Travis J A, Whitley, Darrell, Broderick, Gordon

“…The study and reverse engineering of regulatory networks has gained in recognition as an insightful tool for the qualitative study of biological mechanisms…”
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Post-traumatic stress impact on health outcomes in Gulf War Illness by Jeffrey, Mary, Collado, Fanny, Kibler, Jeffrey, DeLucia, Christian, Messer, Steven, Klimas, Nancy, Craddock, Travis J A

“…Gulf War Illness (GWI) is a chronic, multi-symptomatic disorder affecting an estimated 25-32% of the returning military veterans of the 1990-1991 Persian Gulf…”
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A Projectile Concussive Impact Model Produces Neuroinflammation in Both Mild and Moderate-Severe Traumatic Brain Injury by Michalovicz, Lindsay T, Kelly, Kimberly A, Craddock, Travis J A, O'Callaghan, James P

“…Traumatic brain injury (TBI) is a major cause of death and disability and is experienced by nearly 3 million people annually as a result of falls, vehicular…”
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A pilot reverse virtual screening study suggests toxic exposures caused long-term epigenetic changes in Gulf War Illness by Jean-Pierre, Modeline, Michalovicz, Lindsay T., Kelly, Kimberly A., O'Callaghan, James P., Nathanson, Lubov, Klimas, Nancy, J. A. Craddock, Travis

“…[Display omitted] Gulf War Illness (GWI) is a chronic illness that affects upward of 32% of deployed Veterans to the 1991 Gulf War (GW). The symptoms are…”
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The impact of post-traumatic stress on quality of life and fatigue in women with Gulf War Illness by Shastry, Nandan, Sultana, Esha, Jeffrey, Mary, Collado, Fanny, Kibler, Jeffrey, DeLucia, Christian, Fletcher, Mary Ann, Klimas, Nancy, Craddock, Travis J A

“…Gulf War Illness (GWI) is a chronic, multi-symptomatic disorder characterized by fatigue, muscle pain, cognitive problems, insomnia, rashes,…”
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Inferring Broad Regulatory Biology from Time Course Data: Have We Reached an Upper Bound under Constraints Typical of In Vivo Studies? by Vashishtha, Saurabh, Broderick, Gordon, Craddock, Travis J A, Fletcher, Mary Ann, Klimas, Nancy G

“…There is a growing appreciation for the network biology that regulates the coordinated expression of molecular and cellular markers however questions persist…”
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Periodically Disturbing the Spatial Structure of Biofilms Can Affect the Production of an Essential Virulence Factor in Pseudomonas aeruginosa by Quinn, Rebecca J., Barraza, Ivana, García-Diéguez, Laura, Pajon, Camryn, Krausfeldt, Lauren E., Ibrahim, Kerollos, Enzinna, Laura A., Thorn, Morgan E., Eldakar, Omar Tonsi, Craddock, Travis J. A., Smith, Robert P.

“…Understanding the environmental factors that affect the production of virulence factors has major implications in evolution and medicine. While spatial…”
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DRUGPATH: The Drug Gene Pathway Meta-Database by Jaundoo, Rajeev, Craddock, Travis J A

“…The complexity of modern-day diseases often requires drug treatment therapies consisting of multiple pharmaceutical interventions, which can lead to adverse…”
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Neuropsychological Findings in Gulf War Illness: A Review by Jeffrey, Mary G., Krengel, Maxine, Kibler, Jeffrey L., Zundel, Clara, Klimas, Nancy G., Sullivan, Kimberly, Craddock, Travis J. A.

“…This review paper summarizes the accumulation of research investigating neuropsychological outcomes in veterans with Gulf War illness (GWI). Earlier research…”
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Anesthetics act in quantum channels in brain microtubules to prevent consciousness by Craddock, Travis J A, Hameroff, Stuart R, Ayoub, Ahmed T, Klobukowski, Mariusz, Tuszynski, Jack A

“…The mechanism by which anesthetic gases selectively prevent consciousness and memory (sparing non-conscious brain functions) remains unknown. At the turn of…”
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