Search Results - "Crabbé, Laure"

Signaling pathways of replication stress in yeast by Pardo, Benjamin, Crabbé, Laure, Pasero, Philippe

“…Abstract Eukaryotic cells activate the S-phase checkpoint in response to a variety of events affecting the progression of replication forks, collectively…”
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Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription by Tuduri, Sandie, Crabbé, Laure, Conti, Chiara, De Vos, John, Tourrière, Hélène, Theillet, Charles, Pantesco, Véronique, Holtgreve-Grez, Heidi, Thomas, Aubin, Coquelle, Arnaud, Pommier, Yves, Tazi, Jamal, Jauch, Anna, Pasero, Philippe

“…Topoisomerase I, together with the splicing factor ASF/SF2, prevents the collapse of replication forks by inhibiting the formation of RNA–DNA hybrids during…”
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dNTP pools determine fork progression and origin usage under replication stress by Poli, Jérôme, Tsaponina, Olga, Crabbé, Laure, Keszthelyi, Andrea, Pantesco, Véronique, Chabes, Andrei, Lengronne, Armelle, Pasero, Philippe

“…Intracellular deoxyribonucleoside triphosphate (dNTP) pools must be tightly regulated to preserve genome integrity. Indeed, alterations in dNTP pools are…”
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Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response by Lengronne, Armelle, Crabbé, Laure, De Vos, John, Pasero, Philippe, Thomas, Aubin, Pantesco, Véronique

“…A genome-wide analysis of replication profiles in different budding yeast mutants reveals that the alternative clamp loader component Ctf18 has a key role in…”
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Does interference between replication and transcription contribute to genomic instability in cancer cells? by Tuduri, Sandie, Crabbe, Laure, Tourrière, Hélène, Coquelle, Arnaud, Pasero, Philippe

“…We have recently reported that topoisomerase 1 (Top1) cooperates with ASF/SF2, a splicing factor of the SR family, to prevent unscheduled replication fork…”
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Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription by Tuduri, Sandie, Crabbé, Laure, Conti, Chiara, Tourrière, Hélène, Holtgreve-Grez, Heidi, Jauch, Anna, Pantesco, Véronique, De Vos, John, Thomas, Aubin, Theillet, Charles, Pommier, Yves, Tazi, Jamal, Coquelle, Arnaud, Pasero, Philippe

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Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools by Kychygina, Anna, Dall’Osto, Marina, Allen, Joshua A. M., Cadoret, Jean-Charles, Piras, Vincent, Pickett, Hilda A., Crabbe, Laure

“…Chromatin organization within the nuclear volume is essential to regulate many aspects of its function and to safeguard its integrity. A key player in this…”
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The Telomere Deprotection Response Is Functionally Distinct from the Genomic DNA Damage Response by Cesare, Anthony J., Hayashi, Makoto T., Crabbe, Laure, Karlseder, Jan

“…Loss of chromosome end protection through telomere erosion is a hallmark of aging and senescence. Here we developed an experimental system that mimics…”
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Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma by Gourdier, Isabelle, Del Rio, Maguy, Crabbé, Laure, Candeil, Laurent, Copois, Virginie, Ychou, Marc, Auffray, Charles, Martineau, Pierre, Mechti, Nadir, Pommier, Yves, Pau, Bernard

“…To investigate acquired resistance to oxaliplatin, we selected two resistant clones from the HCT116 cell line. We found that the resistant phenotype was…”
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Telomere Dysfunction as a Cause of Genomic Instability in Werner Syndrome by Crabbe, Laure, Jauch, Anna, Naeger, Colleen M., Holtgreve-Grez, Heidi, Karlseder, Jan

“…Werner syndrome (WS) is a rare human premature aging disease caused by mutations in the gene encoding the RecQ helicase WRN. In addition to the aging features,…”
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Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity by Crabbe, Laure, Verdun, Ramiro E., Haggblom, Candy I., Karlseder, Jan

“…Cells from Werner syndrome patients are characterized by slow growth rates, premature senescence, accelerated telomere shortening rates, and genome…”
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MadID, a Versatile Approach to Map Protein-DNA Interactions, Highlights Telomere-Nuclear Envelope Contact Sites in Human Cells by Sobecki, Michal, Souaid, Charbel, Boulay, Jocelyne, Guerineau, Vincent, Noordermeer, Daan, Crabbe, Laure

“…Mapping the binding sites of DNA- or chromatin-interacting proteins is essential to understanding biological processes. DNA adenine methyltransferase…”
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Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection by Masamsetti, V. Pragathi, Low, Ronnie Ren Jie, Mak, Ka Sin, O’Connor, Aisling, Riffkin, Chris D., Lamm, Noa, Crabbe, Laure, Karlseder, Jan, Huang, David C. S., Hayashi, Makoto T., Cesare, Anthony J.

“…Mitotic catastrophe is a broad descriptor encompassing unclear mechanisms of cell death. Here we investigate replication stress-driven mitotic catastrophe in…”
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Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly by Crabbe, Laure, Cesare, Anthony J., Kasuboski, James M., Fitzpatrick, James A.J., Karlseder, Jan

“…Telomeres are essential for nuclear organization in yeast and during meiosis in mice. Exploring telomere dynamics in living human cells by advanced time-lapse…”
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Non-random spatial organization of telomeres varies during the cell cycle and requires LAP2 and BAF by Keller, Debora, Stinus, Sonia, Umlauf, David, Gourbeyre, Edith, Biot, Eric, Olivier, Nicolas, Mahou, Pierre, Beaurepaire, Emmanuel, Andrey, Philippe, Crabbe, Laure

“…Spatial genome organization within the nucleus influences major biological processes and is impacted by the configuration of linear chromosomes. Here, we…”
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Oxaliplatin-induced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA by GOURDIER, Isabelle, CRABBE, Laure, ANDREAU, Karine, PAU, Bernard, KROEMER, Guido

“…We previously established a model of acquired oxaliplatin resistance derived from the HCT116 oxaliplatin-sensitive cell line (HCT116S) and consisting in two…”
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In the end, it's all structure by Crabbe, Laure, Karlseder, Jan

“…Chromosome end protection is essential for all organisms with linear genomes. Specialized structures, called telomeres, accomplish this protection by forming…”
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dNTP pools determine fork progression and origin usage under replication stress: S-phase progression under replication stress by Poli, Jérôme, Tsaponina, Olga, Crabbé, Laure, Keszthelyi, Andrea, Pantesco, Véronique, Chabes, Andrei, Lengronne, Armelle, Pasero, Philippe

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Methyl Adenine Identification (MadID): High-Resolution Detection of Protein-DNA Interactions by Umlauf, David, Sobecki, Michal, Crabbe, Laure

“…Mapping the binding sites of DNA- or chromatin-interacting proteins is essential to understand many essential biological processes. Methyl Adenine…”
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Mammalian Rap1 widens its impact by Karlseder, Jan, Crabbe, Laure

“…Three recent studies reveal unexpected functions of Rap1, a member of the shelterin complex that protects chromosome ends from the activity of DNA repair…”
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