Search Results - "Crabb, J W"

RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin by Shu, X., Fry, A.M., Tulloch, B., Manson, F.D.C., Crabb, J.W., Khanna, H., Faragher, A.J., Lennon, A., He, S., Trojan, P., Giessl, A., Wolfrum, U., Vervoort, R., Swaroop, A., Wright, A.F.

“…The ORF15 isoform of RPGR (RPGRORF15) and RPGR interacting protein 1 (RPGRIP1) are mutated in a variety of retinal dystrophies but their functions are poorly…”
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Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa by Maw, Marion A, Kennedy, Breandan, Knight, Allison, Bridges, Robyn, Roth, Karen E, Mani, E.J, Mukkadan, J.K, Nancarrow, Derek, Crabb, John W, Denton, Michael J

“…Inadequate levels of all-trans-retinol in the blood cause retinal dysfunction; hence, genes implicated in retinal vitamin-A metabolism represent candidates for…”
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Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line by Zhou, J., Gao, G., Crabb, J.W., Serrero, G.

“…PC cell line is a highly tumorigenic insulin-independent variant from the teratoma-derived adipogenic cell line 1246. Culture medium of PC cells contains a…”
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Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component by Anderegg, R J, Betz, R, Carr, S A, Crabb, J W, Duntze, W

“…Mating type a cells of the yeast Saccharomyces cerevisiae produce a mating hormone, the a-factor, that we have previously characterized as a very hydrophobic,…”
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An Essential Heparin-Binding Domain in the Fibroblast Growth Factor Receptor Kinase by Kan, Mikio, Wang, Fen, Xu, Jianming, Crabb, John W., Hou, Jinzhao, McKeehan, Wallace L.

“…Heparin or heparin-like heparan sulfate proteoglycans are obligatory for activity of the heparin-binding fibroblast growth factor (FGF) family. Heparin…”
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Mechanism of rhodopsin kinase activation by PALCZEWSKI, K, BUCZYLKO, J, KAPLAN, M. W, POLANS, A. S, CRABB, J. W

“…The role of the cytoplasmic loops and C-terminal region of bovine rhodopsin (Rho) in binding and activating rhodopsin kinase was investigated. The ability of…”
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Establishment and characterization of a retinal Muller cell line by Sarthy, VP, Brodjian, SJ, Dutt, K, Kennedy, BN, French, RP, Crabb, JW

“…Primary cultures of Müller cells have proven useful in cell biologic, developmental, and electrophysiological studies of Müller cells. However, the limited…”
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Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin by PALCZEWSKI, K, BUCZYŁKO, J, LEBIODA, L, CRABB, J. W, POLANS, A. S

“…Upon illumination rhodopsin kinase (RK) phosphorylates the visual pigment, rhodopsin, in a reaction that is thought to terminate in part the biochemical events…”
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Identification and characterization of glycosylation sites in human serum clusterin by Kapron, James T., Hilliard, George M., Lakins, Johnathon N., Tenniswood, MARTIN P. R., West, Karen A., Carr, Steven A., Crabb, John W.

“…Clusterin is a ubiquitous, heterodimeric glycoprotein with multiple possible functions that are likely influenced by glycosylation. Identification of…”
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Recoverin, but not visinin, is an autoantigen in the human retina identified with a cancer-associated retinopathy by Polans, AS, Burton, MD, Haley, TL, Crabb, JW, Palczewski, K

“…We investigated the hypothesis that visinin, a cone-specific protein first characterized in chicken retina, is a cone homologue of recoverin and may be the…”
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Drusen Proteome Analysis: An Approach to the Etiology of Age-Related Macular Degeneration by Crabb, John W., Miyagi, Masaru, Gu, Xiaorong, Shadrach, Karen, West, Karen A., Sakaguchi, Hirokazu, Kamei, Motohiro, Hasan, Azeem, Yan, Lin, Rayborn, Mary E., Salomon, Robert G., Hollyfield, Joe G.

“…Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch's membrane and are risk factors for developing age-related…”
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Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification by Furlong, C E, Costa, L G, Hassett, C, Richter, R J, Sundstrom, J A, Adler, D A, Disteche, C M, Omiecinski, C J, Chapline, C, Crabb, J W

“…Human and rabbit paraoxonases/arylesterases were purified to homogeneity by chromatographic and gel electrophoretic/isofocusing procedures coupled with…”
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Expression and immunochemical analysis of rat and human fibroblast growth factor receptor (flg) isoforms by JIANMING XU, NAKAHARA, M, CRABB, J. W, ERGANG SHI, MATUO, Y, FRASER, M, KAN, M, JINZHAO HOU, MCKEEHAN, W. L

“…Potentially 96 splice variants among four genes that code for the human heparin-binding fibroblast growth factor receptor family complicate study of structure,…”
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Carboxyethylpyrrole Protein Adducts and Autoantibodies, Biomarkers for Age-related Macular Degeneration by Gu, Xiaorong, Meer, Susan Gillette, Miyagi, Masaru, Rayborn, Mary E., Hollyfield, Joe G., Crabb, John W., Salomon, Robert G.

“…Age-related macular degeneration (AMD) is a slow, progressive disease with both genetic and environmental risk factors. Free radical-induced oxidation of…”
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Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding by Yu, Y, Hulmes, J D, Herley, M T, Whitney, R G, Crabb, J W, Sato, J D

“…Progress has been made in our understanding of the mechanism by which the binding of vascular endothelial growth factor (VEGF) to cognate receptors induces a…”
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Paneth cell trypsin is the processing enzyme for human defensin-5 by Bevins, Charles L, Ghosh, Dipankar, Porter, Edith, Shen, Bo, Lee, Sarah K, Wilk, Dennis, Drazba, Judith, Yadav, Satya P, Crabb, John W, Ganz, Tomas

“…The antimicrobial peptide human alpha-defensin 5 (HD5) is expressed in Paneth cells, secretory epithelial cells in the small intestine. Unlike other…”
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Proteomic Method Identifies Proteins Nitrated in vivo during Inflammatory Challenge by Aulak, Kulwant S., Miyagi, Masaru, Yan, Lin, West, Karen A., Massillon, Duna, Crabb, John W., Stuehr, Dennis J.

“…Inflammation in asthma, sepsis, transplant rejection, and many neurodegenerative diseases associates an up-regulation of NO synthesis with increased protein…”
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Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence by Hassett, Christopher, Richter, Rebecca J, Humbert, Richard, Chapline, Christine, Crabb, John W, Omiecinski, Curtis J, Furlong, Clement E

“…Serum paraoxonase hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. High serum paraoxonase levels appear to protect against the…”
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Mitochondrial HSP60 (P1 protein) and a HSP70-like protein (mortalin) are major targets for modification during S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-induced nephrotoxicity by BRUSCHI, S. A, WEST, K. A, CRABB, J. W, GUPTA, R. S, STEVENS, J. L

“…The potent and site-selective nephrotoxicity of S-(1,1,2,2-tetrafluoroethyl)-L-cysteine (TFEC) in vivo has been associated with difluorothioamidyl-L-lysine…”
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Identification of the autophosphorylation sites in rhodopsin kinase by PALCZEWSKI, K, BUCZYLKO, J, VAN HOOSER, P, CARR, S. A, HUDDLESTON, M. J, CRABB, J. W

“…Rhodopsin kinase (RK) is a second-messenger-independent protein kinase that is involved in deactivation of photolyzed rhodopsin (Rho*). We have developed a…”
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