Search Results - "Cozzolino, Kira A."

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy by Wang, Lu, Zhao, Zibo, Ozark, Patrick A., Fantini, Damiano, Marshall, Stacy A., Rendleman, Emily J., Cozzolino, Kira A., Louis, Nundia, He, Xingyao, Morgan, Marc A., Takahashi, Yoh-hei, Collings, Clayton K., Smith, Edwin R., Ntziachristos, Panagiotis, Savas, Jeffrey N., Zou, Lihua, Hashizume, Rintaro, Meeks, Joshua J., Shilatifard, Ali

“…The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene…”
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A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation by Morgan, Marc A J, Rickels, Ryan A, Collings, Clayton K, He, Xiaolin, Cao, Kaixiang, Herz, Hans-Martin, Cozzolino, Kira A, Abshiru, Nebiyu A, Marshall, Stacy A, Rendleman, Emily J, Sze, Christie C, Piunti, Andrea, Kelleher, Neil L, Savas, Jeffrey N, Shilatifard, Ali

“…Histone H3 Lys4 (H3K4) methylation is a chromatin feature enriched at gene -regulatory sequences such as promoters and enhancers. Here we identify an…”
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Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology by Savas, Jeffrey N., Wang, Yi-Zhi, DeNardo, Laura A., Martinez-Bartolome, Salvador, McClatchy, Daniel B., Hark, Timothy J., Shanks, Natalie F., Cozzolino, Kira A., Lavallée-Adam, Mathieu, Smukowski, Samuel N., Park, Sung Kyu, Kelly, Jeffery W., Koo, Edward H., Nakagawa, Terunaga, Masliah, Eliezer, Ghosh, Anirvan, Yates, John R.

“…Amyloid beta (Aβ) peptides impair multiple cellular pathways and play a causative role in Alzheimer’s disease (AD) pathology, but how the brain proteome is…”
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Metabolic and Transcriptomic Effects of Mediator Kinase Inhibition on the Interferon Response in Down Syndrome by Cozzolino, Kira A., Jones, Taylor, Ajit, Deepa, Dowell, Robin, Taatjes, Dylan

“…Down syndrome, also known as Trisomy 21, is a condition in humans resulting from full or partial triplication of chromosome 21. Affected individuals present…”
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An isothermal shift assay for proteome scale drug-target identification by Ball, Kerri A., Webb, Kristofor J., Coleman, Stephen J., Cozzolino, Kira A., Jacobsen, Jeremy, Jones, Kevin R., Stowell, Michael H. B., Old, William M.

“…Most small molecule drugs act on living systems by physically interacting with specific proteins and modulating target function. Identification of drug binding…”
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Investigating Kinases as Pharmacological Targets for Down Syndrome by Cozzolino, Kira A

“…Protein kinases are a class of enzymes which reversibly add a negatively-charged phosphate group to the side chains of different amino acids, most commonly…”
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