Search Results - "Coyne, Erin M."

Mapping the breast tumor microenvironment: proximity analysis reveals spatial relationships between macrophage subtypes and metastasis-initiating cancer cells by Grasset, Eloïse M., Deshpande, Atul, Lee, Jae W., Cho, Yeonju, Shin, Sarah M., Coyne, Erin M., Hernandez, Alexei, Yuan, Xuan, Zhang, Zhehao, Cimino-Mathews, Ashley, Ewald, Andrew J., Ho, Won Jin

“…Metastasis is responsible for the majority of cancer-related fatalities. We previously identified specific cancer cell populations responsible for metastatic…”
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Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma by Shu, Daniel H., Ho, Won Jin, Kagohara, Luciane T., Girgis, Alexander, Shin, Sarah M., Danilova, Ludmila, Lee, Jae W., Sidiropoulos, Dimitrios N., Mitchell, Sarah, Munjal, Kabeer, Howe, Kathryn, Bendinelli, Kayla J., Kartalia, Emma, Qi, Hanfei, Mo, Guanglan, Montagne, Janelle, Leatherman, James M., Lopez-Vidal, Tamara Y., Zhu, Qingfeng, Huff, Amanda L., Yuan, Xuan, Hernandez, Alexei, Coyne, Erin M., Zaidi, Neeha, Zabransky, Daniel J., Engle, Logan L., Ogurtsova, Aleksandra, Baretti, Marina, Laheru, Daniel, Durham, Jennifer N., Wang, Hao, Sunshine, Joel C., Johnston, Robert J., Deutsch, Julie Stein, Taube, Janis M., Anders, Robert A., Jaffee, Elizabeth M., Fertig, Elana J., Yarchoan, Mark

“…Tertiary lymphoid structures (TLS) are associated with improved response in solid tumors treated with immune checkpoint blockade, but understanding of the…”
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Immune-related events in individuals with solid tumors on immunotherapy associate with Th17 and Th2 signatures by Kao, Chester J, Charmsaz, Soren, Alden, Stephanie L, Brancati, Madelena, Li, Howard L, Balaji, Aanika, Munjal, Kabeer, Howe, Kathryn, Mitchell, Sarah, Leatherman, James, Griffin, Ervin, Nakazawa, Mari, Tsai, Hua-Ling, Danilova, Ludmila, Thoburn, Chris, Gizzi, Jennifer, Gross, Nicole E, Hernandez, Alexei, Coyne, Erin M, Shin, Sarah M, Babu, Jayalaxmi Suresh, Apostol, George W, Durham, Jennifer, Christmas, Brian J, Konig, Maximilian F, Lipson, Evan J, Naidoo, Jarushka, Cappelli, Laura C, Pabani, Aliyah, Ged, Yasser, Baretti, Marina, Brahmer, Julie, Hoffman-Censits, Jean, Seiwert, Tanguy Y, Garonce-Hediger, Rachel, Guha, Aditi, Bansal, Sanjay, Tang, Laura, Jaffee, Elizabeth M, Chandler, G Scott, Mohindra, Rajat, Ho, Won Jin, Yarchoan, Mark

“…BACKGROUNDImmune-related adverse events (irAEs) and their associated morbidity/mortality are a key concern for patients receiving immune checkpoint inhibitors…”
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Multimodal immune phenotyping reveals microbial-T cell interactions that shape pancreatic cancer by Li, Yan, Chang, Renee B., Stone, Meredith L., Delman, Devora, Markowitz, Kelly, Xue, Yuqing, Coho, Heather, Herrera, Veronica M., Li, Joey H., Zhang, Liti, Choi-Bose, Shaanti, Giannone, Michael, Shin, Sarah M., Coyne, Erin M., Hernandez, Alexei, Gross, Nicole E., Charmsaz, Soren, Ho, Won Jin, Lee, Jae W., Beatty, Gregory L.

“…Microbes are an integral component of the tumor microenvironment. However, determinants of microbial presence remain ill-defined. Here, using spatial-profiling…”
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Phosphodiesterase-5 inhibition collaborates with vaccine-based immunotherapy to reprogram myeloid cells in pancreatic ductal adenocarcinoma by Gross, Nicole E, Zhang, Zhehao, Mitchell, Jacob T, Charmsaz, Soren, Hernandez, Alexei G, Coyne, Erin M, Shin, Sarah M, Vargas Carvajal, Diana Carolina, Sidiropoulos, Dimitrios N, Cho, Yeonju, Mo, Guanglan, Yuan, Xuan, Cannon, Courtney, Suresh Babu, Jayalaxmi, Lyman, Melissa R, Armstrong, Todd, Kagohara, Luciane T, Bever, Katherine M, Le, Dung T, Jaffee, Elizabeth M, Fertig, Elana J, Ho, Won Jin

“…Pancreatic ductal adenocarcinoma (PDAC) is highly lethal and resistant to immunotherapy. Although immune recognition can be enhanced with immunomodulatory…”
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1245 Th17 and Type 2 CD8+ cytokine signatures predict irAEs in solid tumors by Kao, Chester J, Charmsaz, Soren, Brancati, Madalena, Alden, Stephanie L, Li, Howard L, Balaji, Aanika, Munjal, Kabeer, Tsai, Hua-Ling, Danilova, Ludmila, Hernandez, Alexei, Gross, Nicole, Coyne, Erin M, Shin, Sarah M, Durham, Jennifer, Christmas, Brian, Thoburn, Christopher, Konig, Maximilian F, Lipson, Evan J, Naidoo, Jarushka, Cappelli, Laura, Ged, Yasser, Barretti, Marina, Brahmer, Julie, Hoffman-Censits, Jean, Seiwert, Tanguy Y, Garonce-Hediger, Rachel, Bansal, Sanjay, Tang, Laura, Jaffee, Elizabeth M, Scott Chandler, G, Mohindra, Rajat, Ho, Won Jin, Yarchoan, Mark

“…BackgroundImmune related adverse events (irAEs) and their associated morbidity/mortality are a key concern for patients receiving immune checkpoint inhibitors…”
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Durable Response to Combined Nivolumab, Lenvatinib, and Radiation Therapy Against Oligometastatic Hepatocellular Carcinoma by Chun, Sewoon, Coyne, Erin M, Meyer, Jeffrey, Ho, Won Jin

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Abstract 5306: PTPN22 targeting partners with 41BB/OX40 costimulation to overcome anti-PD1 resistance in pancreatic ductal adenocarcinoma by Charmsaz, Soren, Gross, Nicole E., Lee, Jae W., Lin, Jianping, Hernandez, Alexei G., Coyne, Erin M., Shin, Sarah M., Cannon, Courtney, Yuan, Xuan, Zhang, Zhong-Yin, Jaffee, Elizabeth M., Ho, Won Jin

“…Abstract Background: The pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) is notable for a scarcity of cytotoxic T cells and an…”
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Abstract 1384: Highly metastatic PDAC adopts mesenchymal morphology and spatially coordinates endothelial cells with macrophages by Gross, Nicole E., Charmsaz, Soren, Lee, Jae W., Huang, Cheng-Chieh, Hernandez, Alexei G., Shin, Sarah M., Coyne, Erin M., Cannon, Courtney, Yuan, Xuan, Wood, Laura D., Jaffee, Elizabeth M., Ho, Won Jin

“…Abstract Background: Patients with pancreatic ductal adenocarcinoma (PDAC) often have metastatic disease at diagnosis and are highly resistant to cytotoxic and…”
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Abstract PR-08: Reprogramming and selective recruitment of distinct neutrophil subpopulations restrain cancer metastasis by Lee, Jae W, Vargas Carvajal, Diana Caroline, Cho, Yeonju, Shin, Sarah M, Coyne, Erin M, Hernandez, Alexei, Cannon, Courtney D, Yuan, Xuan, Zhang, Zhehao, Gross, Nicole E, Charmsaz, Soren, Shu, Daniel H, Bever, Katherine M, Le, Dung T, Kagohara, Luciane T, Jaffee, Elizabeth M, Ho, Won Jin

“…Abstract Neutrophils are integral to the metastatic tumor microenvironment (TME), and discrete subsets of neutrophils have been associated with pro- and…”
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Abstract 2661: Identification of a novel morphology of tertiary lymphoid structure in patients with hepatocellular carcinoma treated with neoadjuvant immune checkpoint blockade by Shu, Daniel H., Ho, Won Jin, Kagohara, Luciane T., Girgis, Alexander, Shin, Sarah M., Danilova, Ludmila, Lee, Jae W., Sidiropoulos, Dimitrios N. N., Mitchell, Sarah, Munjal, Kabeer, Howe, Kathryn, Bendinelli, Kayla J., Qi, Hanfei, Mo, Guanglan, Montagne, Janelle, Lopez-Vidal, Tamara Y., Zhu, Qingfeng, Huff, Amanda L., Yuan, Xuan, Hernandez, Alexei, Coyne, Erin M., Zaidi, Neeha, Zabransky, Daniel J., Engle, Logan L., Ogurtsova, Aleksandra, Baretti, Marina, Laheru, Daniel, Durham, Jennifer N., Wang, Hao, Anders, Robert, Jaffee, Elizabeth M., Fertig, Elana J., Yarchoan, Mark

“…Abstract Background: Tertiary lymphoid structures (TLS) are ectopic lymphoid follicles that arise in non-lymphoid tissue. TLS may contribute to response to…”
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Abstract 3846: The obesity paradox in immune checkpoint blockade: A pan-tumor analysis by Alden, Stephanie Leigh, Charmsaz, Soren, Brancati, Madelena, Li, Howard L., Warner, Aanika, Munjal, Kabeer, Howe, Kathryn, Mitchell, Sarah, Griffin, Ervin, Nakazawa, Mari, Tsai, Hua-Ling, Danilova, Ludmila, Thoburn, Chris, Gizzi, Jennifer, Hernandez, Alexei, Gross, Nicole E., Coyne, Erin M., Shin, Sarah M., Durham, Jennifer, Konig, Maximilian F., Christmas, Brian J., Lipson, Evan J., Naidoo, Jarushka, Cappelli, Laura C., Pabani, Aliyah, Ged, Yasser, Baretti, Marina, Brahmer, Julie R., Hoffman-Censits, Jean, Seiwert, Tanguy Y., Bansal, Sanjay, Tang, Laura, Jaffee, Elizabeth, Chandler, G Scott, Mohindra, Rajat, Ho, Won Jin, Yarchoan, Mark, Kao, Chester

“…Abstract Background: Chronic systemic inflammation mediated by pro-inflammatory cytokines serves as a major mechanism by which obesity contributes to cancer…”
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