Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives

[Display omitted] •Toxoplasma gondii has a very wide host range, and a remarkable ability within those hosts to infect a wide variety of cells.•Here we review the literature as it pertains to the host response of different cell types to Toxoplasma gondii.•We also review how relatives of T. gondii wi...

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Bibliographic Details
Published in:	International journal for parasitology Vol. 50; no. 5; pp. 423 - 431
Main Authors:	Wong, Zhee S., Borrelli, Sarah L. Sokol, Coyne, Carolyn C., Boyle, Jon P.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-05-2020
Subjects:	Animals Apicomplexa - genetics Apicomplexa - immunology Apicomplexa - metabolism Biological Evolution Cell Line Chemokines Chemokines - metabolism Coccidiosis - immunology Coccidiosis - parasitology Gene Expression Hammondia hammondi Host response Host Specificity - genetics Host-Parasite Interactions - genetics Host-Parasite Interactions - physiology Humans Immunity Interferon-gamma - metabolism Mammals - parasitology Neospora - genetics Neospora - immunology Neospora - metabolism Neospora caninum Placenta Protein Serine-Threonine Kinases - metabolism Protozoan Proteins THP-1 Cells Toxoplasma - genetics Toxoplasma - immunology Toxoplasma - metabolism Toxoplasma gondii Toxoplasmosis - immunology Toxoplasmosis - parasitology Transcriptome Tumor Suppressor Protein p53 - metabolism Virulence - genetics Host response Toxoplasma gondii Placenta Hammondia hammondi Chemokines Neospora caninum
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Summary:	[Display omitted] •Toxoplasma gondii has a very wide host range, and a remarkable ability within those hosts to infect a wide variety of cells.•Here we review the literature as it pertains to the host response of different cell types to Toxoplasma gondii.•We also review how relatives of T. gondii with more restricted host ranges may induce divergent changes in the host cell. Toxoplasma gondii is remarkably unique in its ability to successfully infect vertebrate hosts from multiple phyla and can successfully infect most cells within these organisms. The infection outcome in each of these species is determined by the complex interaction between parasite and host genotype. As techniques to quantify global changes in cell function become more readily available and precise, new data are coming to light about how (i) different host cell types respond to parasitic infection and (ii) different parasite species impact the host. Here we focus on recent studies comparing the response to intracellular parasitism by different cell types and insights into understanding host-parasite interactions from comparative studies on T. gondii and its close extant relatives.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2
ISSN:	0020-7519 1879-0135
DOI:	10.1016/j.ijpara.2020.05.001