Search Results - "Coyle, T."

Glutamate hypothesis in schizophrenia by Uno, Yota, Coyle, Joseph T.

“…Schizophrenia is a chronic and severe psychiatric disorder that has profound impact on an individual’s life and on society. Thus, developing more effective…”
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NMDA receptor and schizophrenia: a brief history by Coyle, Joseph T

“…Although glutamate was first hypothesized to be involved in the pathophysiology of schizophrenia in the 1980s, it was the demonstration that…”
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Glutamate and schizophrenia: beyond the dopamine hypothesis by Coyle, Joseph T

“…: 1. After 50 years of antipsychotic drug development focused on the dopamine D2 receptor, schizophrenia remains a chronic, disabling disorder for most…”
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The Rise and Fall of the d -Serine-Mediated Gliotransmission Hypothesis by Wolosker, Herman, Balu, Darrick T, Coyle, Joseph T

“…d -Serine modulates N-methyl d -aspartate receptors (NMDARs) and regulates synaptic plasticity, neurodevelopment, and learning and memory. However, the primary…”
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The NMDA receptor ‘glycine modulatory site’ in schizophrenia: d -serine, glycine, and beyond by Balu, Darrick T, Coyle, Joseph T

“…Highlights • NMDA receptor (NMDAR) hypofunction contributes to the etiology of schizophrenia. • Serine racemase, a risk gene for schizophrenia, is expressed…”
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Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder by Konopaske, Glenn T, Lange, Nicholas, Coyle, Joseph T, Benes, Francine M

“…Prior studies have demonstrated reduced dendritic spine density in the dorsolateral prefrontal cortex (DLPFC) in schizophrenia. However, it remains unclear how…”
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Fifty Years of Research on Schizophrenia: The Ascendance of the Glutamatergic Synapse by Coyle, Joseph T, Ruzicka, W Brad, Balu, Darrick T

“…Coyle reviews the seminal advances that have transformed understanding of the etiology of schizophrenia and related serious mental disorders since 1970. The…”
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Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia by Lisman, John E, Coyle, Joseph T, Green, Robert W, Javitt, Daniel C, Benes, Francine M, Heckers, Stephan, Grace, Anthony A

“…Many risk genes interact synergistically to produce schizophrenia and many neurotransmitter interactions have been implicated. We have developed a…”
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Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia by Balu, Darrick T., Coyle, Joseph T.

“…▶ This review details how putative schizophrenia risk genes regulate neuroplasticity. ▶ Highlights how risk genes converge to regulate common neurotransmitter…”
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NAAG, NMDA receptor and psychosis by Bergeron, Richard, Coyle, Joseph T

“…At central synapses, glutamate is the main excitatory neurotransmitter. Once released from presynaptic terminals, glutamate activates a number of different…”
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d-Serine, the Shape-Shifting NMDA Receptor Co-agonist by Coyle, Joseph T., Balu, Darrick, Wolosker, Herman

“…Shape-shifting, a phenomenon wide-spread in folklore, refers to the ability to physically change from one identity to another, typically from an innocuous…”
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Cortical Pyramidal Neurons Show a Selective Loss of New Synapses in Chronic Schizophrenia by Coyle, Joseph T

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The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia by Goff, Donald C., Coyle, Joseph T.

“…OBJECTIVE: Research has implicated dysfunction of glutamatergic neurotransmission in the pathophysiology of schizophrenia. This review evaluates evidence from…”
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Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury by Perez, Enmanuel J, Tapanes, Stephen A, Loris, Zachary B, Balu, Darrick T, Sick, Thomas J, Coyle, Joseph T, Liebl, Daniel J

“…After traumatic brain injury (TBI), glial cells have both beneficial and deleterious roles in injury progression and recovery. However, few studies have…”
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Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction by Balu, Darrick T, Li, Yan, Puhl, Matthew D, Benneyworth, Michael A, Basu, Alo C, Takagi, Shunsuke, Bolshakov, Vadim Y, Coyle, Joseph T

“…Schizophrenia is characterized by reduced hippocampal volume, decreased dendritic spine density, altered neuroplasticity signaling pathways, and cognitive…”
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Postsynaptic Serine Racemase Regulates NMDA Receptor Function by Wong, Jonathan M, Folorunso, Oluwarotimi O, Barragan, Eden V, Berciu, Cristina, Harvey, Theresa L, Coyle, Joseph T, Balu, Darrick T, Gray, John A

“…d-serine is the primary NMDAR coagonist at mature forebrain synapses and is synthesized by the enzyme serine racemase (SR). However, our understanding of the…”
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Glutamatergic mechanisms in schizophrenia by Tsai, Guochuan, Coyle, Joseph T

“…Schizophrenia is a chronic, severely disabling brain disorder with symptomatic onset in early adulthood. Typical antipsychotic medications that block dopamine…”
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The Role of Serine Racemase in the Pathophysiology of Brain Disorders by Coyle, Joseph T, Balu, Darrick T

“…The N-methyl-d-aspartate receptor (NMDAR) is unique in requiring two agonists to bind simultaneously to open its cation channel: the neurotransmitter,…”
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Phase I study of BAY 94‐9027, a PEGylated B‐domain‐deleted recombinant factor VIII with an extended half‐life, in subjects with hemophilia A by Coyle, T. E., Reding, M. T., Lin, J. C., Michaels, L. A., Shah, A., Powell, J.

“…Summary Background BAY 94‐9027 is a B‐domain‐deleted recombinant factor VIII (rFVIII) with site‐specific attachment of poly(ethylene glycol) that has shown an…”
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Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease by Balu, Darrick T., Pantazopoulos, Harry, Huang, Cathy C.Y., Muszynski, Kevin, Harvey, Theresa Lynn, Uno, Yota, Rorabaugh, Jacki M., Galloway, Claire R., Botz-Zapp, Christian, Berretta, Sabina, Weinshenker, David, Coyle, Joseph T.

“…Although β-amyloid plaques are a well-recognized hallmark of Alzheimer's disease (AD) neuropathology, no drugs reducing amyloid burden have shown efficacy in…”
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