Search Results - "Coyle, Susette"

APOε4 is associated with enhanced in vivo innate immune responses in human subjects by Gale, Stephen C., MD, Gao, Li, MD, PhD, Mikacenic, Carmen, MD, Coyle, Susette M., RN, Rafaels, Nicholas, MS, Murray Dudenkov, Tanda, MHS, Madenspacher, Jennifer H., MS, Draper, David W., PhD, Ge, William, Aloor, Jim J., PhD, Azzam, Kathleen M., PhD, Lai, Lihua, PhD, Blackshear, Perry J., MD, DPhil, Calvano, Steven E., PhD, Barnes, Kathleen C., PhD, Lowry, Stephen F., MD, Corbett, Siobhan, MD, PhD, Wurfel, Mark M, Fessler, Michael B., MD

“…Background The genetic determinants of the human innate immune response are poorly understood. Apolipoprotein (Apo) E, a lipid-trafficking protein that affects…”
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Human metabolic response to systemic inflammation: assessment of the concordance between experimental endotoxemia and clinical cases of sepsis/SIRS by Kamisoglu, Kubra, Haimovich, Beatrice, Calvano, Steve E, Coyle, Susette M, Corbett, Siobhan A, Langley, Raymond J, Kingsmore, Stephen F, Androulakis, Ioannis P

“…Two recent, independent, studies conducted novel metabolomics analyses relevant to human sepsis progression; one was a human model of endotoxin…”
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In vivo endotoxin synchronizes and suppresses clock gene expression in human peripheral blood leukocytes by Haimovich, Beatrice, Calvano, Jacqueline, Haimovich, Adrian D, Calvano, Steve E, Coyle, Susette M, Lowry, Stephen F

“…The intravenous administration of a bolus dose of endotoxin to healthy human subjects triggers acute systemic inflammatory responses that include cytokine…”
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Retained Surgical Items: A Problem Yet to Be Solved by Stawicki, Stanislaw P.A., MD, FACS, Moffatt-Bruce, Susan D., MD, PhD, FACS, Ahmed, Hesham M., MD, Anderson, Harry L., MD, FACS, Balija, Tara M., MD, Bernescu, Irina, MD, Chan, Liza, MD, Chowayou, Laurie, RN, BSN, Cipolla, James, MD, FACS, Coyle, Susette M., RN, MSN, Gracias, Vicente H., MD, FACS, Gunter, Oliver L., MD, FACS, Marchigiani, Raffaele, MD, Martin, Niels D., MD, FACS, Patel, Jigar, MD, Seamon, Mark J., MD, FACS, Vagedes, Eileen, RN, Ellison, E. Christopher, MD, FACS, Steinberg, Steven M., MD, FACS, Cook, Charles H., MD, FACS, FCCM

“…Background Retained surgical items (RSI) continue to occur. Large RSI studies are few due to low RSI frequency in single institutions and the medicolegal…”
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TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2 by Zhang, Zhiyong, Amorosa, Louis F., Petrova, Anna, Coyle, Susette, Macor, Marie, Nair, Mohan, Lee, Leonard Y., Haimovich, Beatrice

“…TLR4 is implicated in diseases associated with chronic low-grade inflammation, yet homeostatic signaling mechanisms that prevent and/or are affected by chronic…”
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Human Toll-Like Receptor 4 Mutations but Not CD14 Polymorphisms Are Associated with an Increased Risk of Gram-Negative Infections by Agnese, Doreen M., Calvano, Jacqueline E., Hahm, Sae J., Coyle, Susette M., Corbett, Siobhan A., Calvano, Steve E., Lowry, Stephen F.

“…Human toll-like receptor 4 (hTLR4) and CD14 are known to be components of the lipopolysaccharide receptor complex. Our study investigated the association…”
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Insulin-Dependent Regulation of mTORC2-Akt-FoxO Suppresses TLR4 Signaling in Human Leukocytes: Relevance to Type 2 Diabetes by Zhang, Zhiyong, Amorosa, Louis F, Coyle, Susette M, Macor, Marie A, Birnbaum, Morris J, Lee, Leonard Y, Haimovich, Beatrice

“…Leukocyte signaling in patients with systemic insulin resistance is largely unexplored. We recently discovered the presence of multiple Toll-like receptor 4…”
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Natural history of retained surgical items supports the need for team training, early recognition, and prompt retrieval by Stawicki, S. Peter, M.D, Cook, Charles H., M.D, Anderson, Harry L., M.D, Chowayou, Laurie, R.N., B.S.N, Cipolla, James, M.D, Ahmed, Hesham M., M.D, Coyle, Susette M., R.N., M.S.N, Gracias, Vicente H., M.D, Evans, David C., M.D, Marchigiani, Raffaele, M.D, Adams, Raeanna C., M.D, Seamon, Mark J., M.D, Martin, Niels D., M.D, Steinberg, Steven M., M.D, Moffatt-Bruce, Susan D., M.D., Ph.D

“…Abstract Background Unintentionally retained items feature prominently among surgical “never events.” Our knowledge of these rare occurrences, including…”
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Experimental human endotoxemia: a model of the systemic inflammatory response syndrome? by Calvano, Steve E, Coyle, Susette M

“…The normal human intravenous endotoxin model has been used for more than 50 years. It was once considered a possible model of sepsis, but, because no infection…”
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Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes by Zhang, Zhiyong, Amorosa, Louis F, Coyle, Susette M, Macor, Marie A, Lubitz, Sara E, Carson, Jeffrey L, Birnbaum, Morris J, Lee, Leonard Y, Haimovich, Beatrice

“…LPS-induced TLR4 activation alters cellular bioenergetics and triggers proteolytic cleavage of AMPKα and HIF-1α expression in leukocytes. In human leukocytes,…”
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Temporal Metabolic Profiling of Plasma During Endotoxemia in Humans by Kamisoglu, Kubra, Sleight, Kirsten E, Calvano, Steve E, Coyle, Susette M, Corbett, Siobhan A, Androulakis, Ioannis P

“…ABSTRACTEndotoxemia induced by the administration of low-dose lipopolysaccharide (LPS) to healthy human volunteers is a well-established experimental protocol…”
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Integrated Transcriptional and Metabolic Profiling in Human Endotoxemia by Kamisoglu, Kubra, Calvano, Steve E, Coyle, Susette M, Corbett, Siobhan A, Androulakis, Ioannis P

“…ABSTRACTIn this meta-study, we aimed to integrate biological insights gained from two levels of -omics analyses on the response to systemic inflammation…”
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Physiologic Variability at the Verge of Systemic Inflammation: Multiscale Entropy of Heart Rate Variability Is Affected by Very Low Doses of Endotoxin by Herlitz, Georg N, Arlow, Renee L, Cheung, Nora H, Coyle, Susette M, Griffel, Benjamin, Macor, Marie A, Lowry, Stephen F, Calvano, Steve E, Gale, Stephen C

“…ABSTRACTIntroductionHuman injury or infection induces systemic inflammation with characteristic neuroendocrine responses. Fluctuations in autonomic function…”
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Relationship of basal heart rate variability to in vivo cytokine responses after endotoxin exposure by Jan, Badar U, Coyle, Susette M, Macor, Marie A, Reddell, Michael, Calvano, Steve E, Lowry, Stephen F

“…Autonomic inputs from the sympathetic and parasympathetic nervous systems, as measured by heart rate variability (HRV), have been reported to correlate to the…”
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A novel model of common Toll-like receptor 4- and injury-induced transcriptional themes in human leukocytes by Haimovich, Beatrice, Reddell, Michael T, Calvano, Jacqueline E, Calvano, Steve E, Macor, Marie A, Coyle, Susette M, Lowry, Stephen F

“…An endotoxin challenge, sepsis, and injury/trauma, trigger significant changes in human peripheral blood leukocytes (PBL) gene expression. In this study, we…”
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Cellular Metabolic Regulators: Novel Indicators of Low-Grade Inflammation in Humans by Haimovich, Beatrice, Zhang, Zhiyong, Calvano, Jacqueline E, Calvano, Steve E, Kumar, Ashwini, Macor, Marie A, Corbett, Siobhan, Coyle, Susette M, Lowry, Stephen F

“…OBJECTIVE:The Toll-like receptor 4 (TLR4) ligand endotoxin triggers robust systemic inflammatory responses in humans at doses equal to or greater than 1 ng/kg…”
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Gender influences in vivo human responses to endotoxin by Coyle, Susette M, Calvano, Steve E, Lowry, Stephen F

“…Gender appears to influence systemic and organ-specific inflammatory sequelae of ischemia-reperfusion and infectious challenge in many animal models. Despite…”
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In vivo endotoxin synchronizes and suppresses clock gene expression in human peripheral blood leukocytes by HAIMOVICH, Beatrice, CALVANO, Jacqueline, HAIMOVICH, Adrian D, CALVANO, Steve E, COYLE, Susette M, LOWRY, Stephen F

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Influence of Acute Epinephrine Infusion on Endotoxin-Induced Parameters of Heart Rate Variability: A Randomized Controlled Trial by JAN, Badar U, COYLE, Susette M, OIKAWA, Leo O, LU, Shou-En, CALVANO, Steve E, LEHRER, Paul M, LOWRY, Stephen F

“…To determine whether the acute anti-inflammatory influence of epinephrine (EPI) extends to changes in heart rate variability (HRV) induced by the prototypical…”
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Voluntarily Produced Increases in Heart Rate Variability Modulate Autonomic Effects of Endotoxin Induced Systemic Inflammation: An Exploratory Study by Lehrer, Paul, Karavidas, Maria Katsamanis, Lu, Shou-En, Coyle, Susette M., Oikawa, Leo O., Macor, Marie, Calvano, Steve E., Lowry, Stephen F.

“…Exposure of healthy people to lipopolysaccharide (LPS; endotoxin) produces a pro-inflammatory response, subjective symptoms, and decreased heart rate…”
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