Search Results - "Coyle, Christopher"

Humanization and functional characterization of enhanced coagulation factor IX variants identified through ancestral sequence reconstruction by Coyle, Christopher W., Knight, Kristopher A., Brown, Harrison C., George, Stephan N., Denning, Gabriela, Branella, Gianna M., Childers, Kenneth C., Spiegel, P. Clint, Spencer, H. Trent, Doering, Christopher B.

“…Laboratory resurrection of ancient coagulation factor (F) IX variants generated through ancestral sequence reconstruction led to the discovery of a…”
Get full text

The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain by Smith, Ian W., d'Aquino, Anne E., Coyle, Christopher W., Fedanov, Andrew, Parker, Ernest T., Denning, Gabriela, Spencer, Harold Trent, Lollar, Pete, Doering, Christopher B., Spiegel, Paul Clint

“…Background Coagulation factor VIII represents one of the oldest protein‐based therapeutics, serving as an effective hemophilia A treatment for half a century…”
Get full text

Novel ternary molten salt electrolytes for intermediate-temperature sodium/nickel chloride batteries by Li, Guosheng, Lu, Xiaochuan, Coyle, Christopher A., Kim, Jin Y., Lemmon, John P., Sprenkle, Vincent L., Yang, Zhenguo

“…The sodium–nickel chloride (ZEBRA) battery is operated at relatively high temperature (250–350 °C) to achieve adequate electrochemical performance. Reducing…”
Get full text

Photoperiodic and ovarian steroid regulation of histone deacetylase 1, 2, and 3 in Siberian hamster ( Phodopus sungorus ) reproductive tissues by Lynch, Eloise W.J, Coyle, Christopher S, Stevenson, Tyler J

“…Highlights • Short day photoperiods reduced hdac1 and induced hdac3 in hamster testes. • Short day photoperiods elevated uterine hdac2 expression. • Estradiol…”
Get full text

Emergency Etoposide-Cisplatin (Em-EP) for patients with germ cell tumours (GCT) and trophoblastic neoplasia (TN) by Chan Wah Hak, Charleen, Coyle, Christopher, Kocache, Arwa, Short, Dee, Sarwar, Naveed, Seckl, Michael J, Gonzalez, Michael A

“…Etoposide (E) at 100 mg/m combined with Cisplatin (P) at 20 mg/m represents an induction 2-day regimen embedded in our clinical practice for patients with…”
Get full text

Doped yttrium chromite–ceria composite as a redox-stable and sulfur-tolerant anode for solid oxide fuel cells by Yoon, Kyung Joong, Coyle, Christopher A., Marina, Olga A.

“…A new high performance ceramic solid oxide fuel cell (SOFC) anode, Ca- and Co-doped yttrium chromite (YCCC)–samaria-doped ceria (SDC) composite, that resists…”
Get full text

Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions by Curtis, Daniel J., Sood, Aman, Phillips, Tom J., Leinster, Veronica H.L., Nishiguchi, Akihiro, Coyle, Christopher, Lacharme-Lora, Lizeth, Beaumont, Oliver, Kemp, Helena, Goodall, Roberta, Cornes, Leila, Giugliano, Michele, Barone, Rocco A., Matsusaki, Michiya, Akashi, Mitsuru, Tanaka, Hiroyoshi Y., Kano, Mitsunobu, McGarvey, Jennifer, Halemani, Nagaraj D., Simon, Katja, Keehan, Robert, Ind, William, Masters, Tracey, Grant, Simon, Athwal, Sharan, Collett, Gavin, Tannetta, Dionne, Sargent, Ian L., Scull-Brown, Emma, Liu, Xun, Aquilina, Kristian, Cohen, Nicki, Lane, Jon D., Thoresen, Marianne, Hanley, Jon, Randall, Andrew, Case, C. Patrick

“…Some psychiatric diseases in children and young adults are thought to originate from adverse exposures during foetal life, including hypoxia and…”
Get full text

Waddlia chondrophila infects and multiplies in ovine trophoblast cells stimulating an inflammatory immune response by Wheelhouse, Nick, Coyle, Christopher, Barlow, Peter G, Mitchell, Stephen, Greub, Gilbert, Baszler, Tim, Rae, Mick T, Longbottom, David

“…Waddlia chondrophila (W. chondrophila) is an emerging abortifacient organism which has been identified in the placentae of humans and cattle. The organism is a…”
Get full text

Identification of coagulation factor IX variants with enhanced activity through ancestral sequence reconstruction by Knight, Kristopher A., Coyle, Christopher W., Radford, Caelan E., Parker, Ernest T., Fedanov, Andrew, Shields, Jordan M., Szlam, Fania, Purchel, Anatolii, Chen, Michelle, Denning, Gabriela, Sniecinski, Roman M., Lollar, Pete, Spencer, H. Trent, Gaucher, Eric A., Doering, Christopher B.

“…Orthologous proteins contain sequence disparity guided by natural selection. In certain cases, species-specific protein functionality predicts pharmacological…”
Get full text

Interactions of 4,4′-diaminoazobenzene derivatives with telomeric G-quadruplex DNA by McCallum, Jeremy E. B., Coyle, Christopher W., Elson, Ryan R., Titterington, Blake A.

“…The development of small molecules to stabilize the G-quadruplex structure has garnered significant attention for anticancer drug discovery. Herein, we report…”
Get full text

Molecular coevolution of coagulation factor VIII and von Willebrand factor by Zakas, Philip M., Coyle, Christopher W., Brehm, Anja, Bayer, Marion, Solecka-Witulska, Barbara, Radford, Caelan E., Brown, Christine, Nesbitt, Kate, Dwyer, Courtney, Kannicht, Christoph, Spencer, H. Trent, Gaucher, Eric A., Doering, Christopher B., Lillicrap, David

“…Ancestral sequence reconstruction provides a unique platform for investigating the molecular evolution of single gene products and recently has shown success…”
Get full text

Electrochemical, structural and surface characterization of nickel/zirconia solid oxide fuel cell anodes in coal gas containing antimony by Marina, Olga A., Pederson, Larry R., Coyle, Christopher A., Thomsen, Edwin C., Nachimuthu, Ponnusamy, Edwards, Danny J.

“…[Display omitted] ► Interactions of antimony with nickel-zirconia anode are investigated. ► Antimony rapidly poisons nickel due to the formation of a surface…”
Get full text

Effects of thermal cycling and thermal aging on the hermeticity and strength of silver–copper oxide air-brazed seals by Scott Weil, K., Coyle, Christopher A., Darsell, Jens T., Xia, Gordon G., Hardy, John S.

“…Thermal cycle and exposure tests were conducted on ceramic-to-metal joints prepared by a new sealing technique. Known as reactive air brazing, this joining…”
Get full text

Reduced activity without hyperphagia contributes to obesity in Tubby mutant mice by Coyle, Christopher A, Strand, Sarah C, Good, Deborah J

“…Abstract The Tub gene was originally identified as a spontaneous mutation in C57Bl/6J mice, and associated with adult-onset obesity ( Tub MUT mice). Although…”
Get full text

Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity by Good, Deborah J, Coyle, Christopher A, Fox, Dana L

“…In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced…”
Get full text

Interaction of coal-derived synthesis gas impurities with solid oxide fuel cell metallic components by Marina, Olga A., Pederson, Larry R., Coyle, Christopher A., Edwards, Danny J., Chou, Yeong-Shyung, Cramer, Carolyn N.

“…Oxidation-resistant alloys find use as interconnect materials, heat exchangers, and gas supply tubing in solid oxide fuel cell (SOFC) systems, especially when…”
Get full text

Pathological pulses in PCOS by Coyle, Christopher, Campbell, Rebecca E.

“…Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine disorder associated with hyperandrogenism and anovulation. Although a spectrum disorder, many…”
Get full text

Reduced voluntary activity precedes adult-onset obesity in Nhlh2 knockout mice by Coyle, Christopher A, Jing, Enxuan, Hosmer, Trina, Powers, J.Bradley, Wade, George, Good, Deborah J

“…Targeted deletion of the neuronal basic helix–loop–helix transcription factor Nhlh2 results in adult-onset obesity in mice. Measurement of body weight and body…”
Get full text

Why did shareholder liability disappear? by Bogle, David A., Campbell, Gareth, Coyle, Christopher, Turner, John D.

Get full text

The Nhlh2 transcription factor is required for female sexual behavior and reproductive longevity by Johnson, Sarah A., Marı́n-Bivens, Carrie L., Miele, Melissa, Coyle, Christopher A., Fissore, Rafael, Good, Deborah J.

“…Nhlh2 is a member of the basic helix-loop-helix (bHLH) transcription factor family and is expressed in developing and adult neuroendocrine tissues such as the…”
Get full text