Search Results - "Coyle, Anthony J."

Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation by Lambrecht, Bart N., De Veerman, Marijke, Coyle, Anthony J., Gutierrez-Ramos, Jose-Carlos, Thielemans, Kris, Pauwels, Romain A.

Get full text

Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes by Henault, Jill, Martinez, Jennifer, Riggs, Jeffrey M., Tian, Jane, Mehta, Payal, Clarke, Lorraine, Sasai, Miwa, Latz, Eicke, Brinkmann, Melanie M., Iwasaki, Akiko, Coyle, Anthony J., Kolbeck, Roland, Green, Douglas R., Sanjuan, Miguel A.

“…Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. However, association of host DNA with autoantibodies activates…”
Get full text

HMGB1 and RAGE in inflammation and cancer by Sims, Gary P, Rowe, Daniel C, Rietdijk, Svend T, Herbst, Ronald, Coyle, Anthony J

“…The immune system has evolved to respond not only to pathogens, but also to signals released from dying cells. Cell death through necrosis induces…”
Get full text

IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization by Chu, Derek K., BHSc, Llop-Guevara, Alba, BHSc, Walker, Tina D., BSc, Flader, Kristin, BSc, Goncharova, Susanna, MD, PhD, Boudreau, Jeanette E., PhD, Moore, Cheryl Lynn, BSc, In, Tracy Seunghyun, BHSc, Waserman, Susan, MD, MSc, Coyle, Anthony J., PhD, Kolbeck, Roland, PhD, Humbles, Alison A., PhD, Jordana, Manel, MD, PhD

“…Background Allergen exposure at lung and gut mucosae can lead to aberrant TH 2 immunity and allergic disease. The epithelium-associated cytokines thymic…”
Get full text

IL-9 as a mediator of Th17-driven inflammatory disease by Nowak, Elizabeth C, Weaver, Casey T, Turner, Henrietta, Begum-Haque, Sakhina, Becher, Burkhard, Schreiner, Bettina, Coyle, Anthony J, Kasper, Lloyd H, Noelle, Randolph J

“…We report that like other T cells cultured in the presence of transforming growth factor (TGF) beta, Th17 cells also produce interleukin (IL) 9. Th17 cells…”
Get full text

Expression of High-Mobility Group Box 1 and of Receptor for Advanced Glycation End Products in Chronic Obstructive Pulmonary Disease by FERHANI, Nassima, LETUVE, Séverine, AUBIER, Michel, PRETOLANI, Marina, KOZHICH, Alexander, THIBAUDEAU, Olivier, GRANDSAIGNE, Martine, MARET, Marielle, DOMBRET, Marie-Christine, SIMS, Gary P, KOLBECK, Roland, COYLE, Anthony J

“…Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation and remodeling. High-mobility group box 1 (HMGB1), a nuclear protein that…”
Get full text

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE by Coyle, Anthony J, Tian, Jane, Avalos, Ana Maria, Mao, Su-Yau, Chen, Bo, Senthil, Kannaki, Wu, Herren, Parroche, Peggy, Drabic, Stacey, Golenbock, Douglas, Sirois, Cherilyn, Hua, Jing, An, Ling Ling, Audoly, Laurent, La Rosa, Greg, Bierhaus, Angelika, Naworth, Peter, Marshak-Rothstein, Ann, Crow, Mary K, Fitzgerald, Katherine A, Latz, Eicke, Kiener, Peter A

“…Increased concentrations of DNA-containing immune complexes in the serum are associated with systemic autoimmune diseases such as lupus. Stimulation of…”
Get full text

Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti–IL-5 receptor α antibody, in a phase I study of subjects with mild asthma by Busse, William W., MD, Katial, Rohit, MD, Gossage, David, MD, MBA, Sari, Suha, PhD, Wang, Bing, PhD, Kolbeck, Roland, PhD, Coyle, Anthony J., PhD, Koike, Masamichi, PhD, Spitalny, George L., PhD, Kiener, Peter A., PhD, Geba, Gregory P., MD, MPH, Molfino, Nestor A., MD

“…Background Increased eosinophil levels have been linked to airway inflammation and asthma exacerbations. IL-5 is responsible for eosinophil differentiation,…”
Get full text

Human amyotrophic lateral sclerosis excitability phenotype screen: Target discovery and validation by Huang, Xuan, Roet, Kasper C.D., Zhang, Liying, Brault, Amy, Berg, Allison P., Jefferson, Anne B., Klug-McLeod, Jackie, Leach, Karen L., Vincent, Fabien, Yang, Hongying, Coyle, Anthony J., Jones, Lyn H., Frost, Devlin, Wiskow, Ole, Chen, Kuchuan, Maeda, Rie, Grantham, Alyssa, Dornon, Mary K., Klim, Joseph R., Siekmann, Marco T., Zhao, Dongyi, Lee, Seungkyu, Eggan, Kevin, Woolf, Clifford J.

“…Drug development is hampered by poor target selection. Phenotypic screens using neurons differentiated from patient stem cells offer the possibility to…”
Get full text

Characterization of Tiki, a New Family of Wnt-specific Metalloproteases by Zhang, Xinjun, MacDonald, Bryan T., Gao, Huilan, Shamashkin, Michael, Coyle, Anthony J., Martinez, Robert V., He, Xi

“…The Wnt family of secreted glycolipoproteins plays pivotal roles in development and human diseases. Tiki family proteins were identified as novel Wnt…”
Get full text

Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1 by Sutterwala, Fayyaz S., Ogura, Yasunori, Szczepanik, Marian, Lara-Tejero, Maria, Lichtenberger, G. Scott, Grant, Ethan P., Bertin, John, Coyle, Anthony J., Galán, Jorge E., Askenase, Philip W., Flavell, Richard A.

“…Mutations in the NALP3/CIAS1/cryopyrin gene are linked to three autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory syndrome, and…”
Get full text

Role of YKL-40 in Bronchial Smooth Muscle Remodeling in Asthma by BARA, Imane, OZIER, Annaig, WOODS, Joanne, DE LARA, Jose-Manuel Tunon, MARTHAN, Roger, BERGER, Patrick, GIRODET, Pierre-Olivier, CARVALHO, Gabrielle, CATTIAUX, Jennifer, BEGUERET, Hugues, THUMEREL, Matthieu, OUSOVA, Olga, KOLBECK, Roland, COYLE, Anthony J

“…Bronchial remodeling, including increased bronchial smooth muscle (BSM) mass, contributes to bronchial obstruction in asthma. However, its mechanisms are…”
Get full text

Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein–Gremlin signaling pathways by Tumelty, Kathleen E., Higginson-Scott, Nathan, Fan, Xueping, Bajaj, Piyush, Knowlton, Kelly M., Shamashkin, Michael, Coyle, Anthony J., Lu, Weining, Berasi, Stephen P.

“…Slit guidance ligand 2 (SLIT2) is a large, secreted protein that binds roundabout (ROBO) receptors on multiple cell types, including neurons and kidney…”
Get full text

Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis by David, Tovo, Kim, Yun Cheol, Ely, Lauren K, Rondon, Isaac, Gao, Huilan, O'Brien, Peter, Bolt, Michael W, Coyle, Anthony J, Garcia, Jorge L, Flounders, Eric A, Mikita, Thomas, Coughlin, Shaun R

“…Thrombosis is a major cause of morbidity and mortality. Current antithrombotic drugs are not ideal in that they must balance prevention of thrombosis against…”
Get more information

A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure by Llop-Guevara, Alba, Chu, Derek K, Walker, Tina D, Goncharova, Susanna, Fattouh, Ramzi, Silver, Jonathan S, Moore, Cheryl Lynn, Xie, Juliana L, O'Byrne, Paul M, Coyle, Anthony J, Kolbeck, Roland, Humbles, Alison A, Stämpfli, Martin R, Jordana, Manel

“…Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction…”
Get full text

Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis by Lara-Tejero, Maria, Sutterwala, Fayyaz S, Ogura, Yasunori, Grant, Ethan P, Bertin, John, Coyle, Anthony J, Flavell, Richard A, Galán, Jorge E

“…Caspase-1 is activated by a variety of stimuli after the assembly of the "inflammasome," an activating platform made up of a complex of the NOD-LRR family of…”
Get full text

Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease by Delaney, Tracy A, Morehouse, Chris, Brohawn, P Zachary, Groves, Christopher, Colonna, Marco, Yao, Yihong, Sanjuan, Miguel, Coyle, Anthony J

“…Type I IFNs play a critical role in the immune response to viral infection and may also drive autoimmunity through modulation of monocyte maturation and…”
Get full text

IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice by Botelho, Fernando M, Bauer, Carla M T, Finch, Donna, Nikota, Jake K, Zavitz, Caleb C J, Kelly, Ashling, Lambert, Kristen N, Piper, Sian, Foster, Martyn L, Goldring, James J P, Wedzicha, Jadwiga A, Bassett, Jennifer, Bramson, Jonathan, Iwakura, Yoichiro, Sleeman, Matthew, Kolbeck, Roland, Coyle, Anthony J, Humbles, Alison A, Stämpfli, Martin R

“…Cigarette smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality…”
Get full text

Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice by Arias, Katherine, BHSc, Chu, Derek K., BHSc, Flader, Kristin, BSc, Botelho, Fernando, PhD, Walker, Tina, BSc, Arias, Natalia, Humbles, Alison A., PhD, Coyle, Anthony J., PhD, Oettgen, Hans C., MD, PhD, Chang, Hyun-Dong, PhD, Van Rooijen, Nico, PhD, Waserman, Susan, MD, MSc, Jordana, Manel, MD, PhD

“…Background Food-induced anaphylaxis is often a severe allergic reaction characterized by multiorgan dysfunction and a potentially fatal outcome. Objectives We…”
Get full text

Mycophenolic acid differentially impacts B cell function depending on the stage of differentiation by Karnell, Jodi L, Karnell, 3rd, Fredrick G, Stephens, Geoffrey L, Rajan, Bhargavi, Morehouse, Chris, Li, Ying, Swerdlow, Bonnie, Wilson, Mildred, Goldbach-Mansky, Raphaela, Groves, Christopher, Coyle, Anthony J, Herbst, Ronald, Ettinger, Rachel

“…Production of pathogenic Abs contributes to disease progression in many autoimmune disorders. The immunosuppressant agent mycophenolic acid (MPA) has shown…”
Get full text