Search Results - "Coyan, Fabien C"
-
1
Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism
Published in Scientific reports (03-04-2020)“…Prokaryotic Na V channels are tetramers and eukaryotic Na V channels consist of a single subunit containing four domains. Each monomer/domain contains six…”
Get full text
Journal Article -
2
A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation
Published in PloS one (28-03-2014)“…Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1, including R243H,…”
Get full text
Journal Article -
3
C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation
Published in The Journal of biological chemistry (20-10-2017)“…Voltage-gated Na+ (NaV) channels are key regulators of myocardial excitability, and Ca2+/calmodulin-dependent protein kinase II (CaMKII)-dependent alterations…”
Get full text
Journal Article -
4
C-terminal phosphorylation of Na V 1.5 impairs FGF13-dependent regulation of channel inactivation
Published in The Journal of biological chemistry (20-10-2017)“…Voltage-gated Na (Na ) channels are key regulators of myocardial excitability, and Ca /calmodulin-dependent protein kinase II (CaMKII)-dependent alterations in…”
Get full text
Journal Article -
5
Cholesterol regulation of ion channels: Crosstalk in proteins, crosstalk in lipids
Published in Channels (Austin, Tex.) (01-11-2013)Get full text
Journal Article -
6
Opposite Effects of the S4–S5 Linker and PIP2 on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels
Published in Frontiers in pharmacology (2012)“…Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1–S6), with each S1–S4 segments forming a…”
Get full text
Journal Article -
7
In KCNQ1 Channels, a Long QT Mutation Induces a Regulation by Cholesterol Instead of Phosphatidylinositol-4,5-Bisphosphate
Published in Biophysical journal (28-01-2014)Get full text
Journal Article -
8
A Long QT Mutation Substitutes Cholesterol for Phosphatidylinositol-4,5-Bisphosphate in KCNQ1 Channel Regulation: e93255
Published in PloS one (01-03-2014)“…Introduction Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1,…”
Get full text
Journal Article -
9
Opposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels
Published in Frontiers in pharmacology (2012)“…Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1-S6), with each S1-S4 segments forming a…”
Get full text
Journal Article