Search Results - "Coxon, A B"

Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation by KOMIYA, T, PARK, Y, MODI, S, COXON, A. B, OH, H, KAYE, F. J

“…Mucoepidermoid (MEC) salivary gland tumors arise from a t(11;19) rearrangement which generates a fusion oncogene, Mect1-Maml2, that functions to activate…”
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Temperature-Sensitive RB Mutations Linked to Incomplete Penetrance of Familial Retinoblastoma in 12 Families by Otterson, Gregory A., Modi, Sanjay, Nguyen, Kari, Coxon, Amy B., Kaye, Frederic J.

“…The tumor-suppressor activity of the retinoblastoma protein (RB) is encoded within a protein-binding (“pocket”) domain that is targeted for mutations in all…”
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Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding by CHEN, W.-D, OTTERSON, G. A, LIPKOWITZ, S, KHLEIF, S. N, COXON, A. B, KAYE, F. J

“…Dephosphorylation of the RB protein has been reported to be associated with apoptosis. In contrast, we show that treatment of HL60 cells with etoposide or…”
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RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer by COXON, A. B, WARD, J. M, GERADTS, J, OTTERSON, G. A, ZAJAC-KAYE, M, KAYE, F. J

“…Mice bred to carry germline Rb and p53 null alleles are associated with a tumor spectrum that overlaps with the inherited multiple endocrine neoplasia-1 (MEN1)…”
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Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein by Kim, Y W, Otterson, G A, Kratzke, R A, Coxon, A B, Kaye, F J

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors by Kratzke, R A, Otterson, G A, Hogg, A, Coxon, A B, Geradts, J, Cowell, J K, Kaye, F J

“…While familial retinoblastoma has served as the paradigm for the two-hit theory of tumorigenesis and for the concept of the tumor suppressor gene, the etiology…”
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Incomplete Penetrance of Familial Retinoblastoma Linked to Germ-Line Mutations that Result in Partial Loss of RB Function by Otterson, G A, Chen, W d, Coxon, A B, Khleif, S N, Kaye, F J

“…To study the molecular basis for the clinical phenotype of incomplete penetrance of familial retinoblastoma, we have examined the functional properties of…”
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Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer by MODI, Sanjay, KUBO, Akihito, OIE, Herbert, COXON, Amy B, REHMATULLA, Ahad, KAYE, Frederic J

“…Mutational inactivation of the RB-related gene RBL2/p130 has been reported as a common and important prognostic factor in human lung cancer. To examine the…”
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t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway by Tonon, G, Modi, S, Wu, L, Kubo, A, Coxon, A B, Komiya, T, O'Neil, K, Stover, K, El-Naggar, A, Griffin, J D, Kirsch, I R, Kaye, F J

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t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway by Kaye, Frederic J, Tonon, Giovanni, Modi, Sanjay, Wu, Lizi, Kubo, Akihito, Coxon, Amy B, Komiya, Takefumi, O'Neil, Kevin, Stover, Kristen, El-Naggar, Adel, Griffin, James D, Kirsch, Ilan R

“…Truncation of Notch1 has been shown to cause a subtype of acute leukemia, and activation of Notch4 has been associated with mammary and salivary gland…”
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Erratum: t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway by Tonon, G, Modi, S, Wu, L, Kubo, A, Coxon, A B, Komiya, T, O'Neil, K, Stover, K, El-Naggar, A, Griffin, J D, Kirsch, I R, Kaye, F J

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CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine by Otterson, G A, Khleif, S N, Chen, W, Coxon, A B, Kaye, F J

“…Absent expression of the cyclin dependent kinase-inhibitor, p16INK4, is observed in a wide range of primary human cancers. Although homozygous deletions and…”
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