Search Results - "Cox, Philip B"

Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection by DeGoey, David A, Chen, Hui-Ju, Cox, Philip B, Wendt, Michael D

“…Recently, there has been an increasing focus on the pursuit of targets considered to be less druggable that offer potential for development of promising new…”
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Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site by Goedken, Eric R., Argiriadi, Maria A., Dietrich, Justin D., Petros, Andrew M., Krishnan, Navasona, Panchal, Sanjay C., Qiu, Wei, Wu, Haihong, Zhu, Haizhong, Adams, Ashley M., Bodelle, Pierre M., Goguen, Lucas, Richardson, Paul L., Slivka, Peter F., Srikumaran, Myron, Upadhyay, Anup K., Wu, Bainan, Judge, Russell A., Vasudevan, Anil, Gopalakrishnan, Sujatha M., Cox, Philip B., Stoll, Vincent S., Sun, Chaohong

“…Anti-IL17A therapies have proven effective for numerous inflammatory diseases including psoriasis, axial spondylitis and psoriatic arthritis. Modulating and/or…”
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Abbott Physicochemical Tiering (APT)—A unified approach to HTS triage by Cox, Philip B., Gregg, Robert J., Vasudevan, Anil

“…An in silico tool has been developed to help prioritize hits from HTS based on multi-parametric physicochemical properties. This Abbott Physicochemical Tiering…”
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Phenols in Pharmaceuticals: Analysis of a Recurring Motif by Scott, Kevin A., Cox, Philip B., Njardarson, Jon T.

“…Phenols and phenolic ethers are significant scaffolds recurring both in nature and among approved small-molecule pharmaceuticals. This compendium presents the…”
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Contemporary Computational Applications and Tools in Drug Discovery by Cox, Philip B., Gupta, Rishi

“…In the past decade or so there has been a dramatic increase in the number of computational applications and tools that have been developed to enable medicinal…”
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Beyond Rule of Five and PROTACs in Modern Drug Discovery: Polarity Reducers, Chameleonicity, and the Evolving Physicochemical Landscape by Price, Edward, Weinheimer, Manuel, Rivkin, Alexey, Jenkins, Gary, Nijsen, Marjoleen, Cox, Philip B., DeGoey, David

“…Developing orally bioavailable drugs demands an understanding of absorption in early drug development. Traditional methods and physicochemical properties…”
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An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023) by Marshall, Christopher M., Federice, John G., Bell, Chloe N., Cox, Philip B., Njardarson, Jon T.

“…This Perspective is a continuation of our analysis of U.S. FDA-approved small-molecule drugs (1938–2012) containing nitrogen heterocycles. In this study we…”
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Design and Synthesis of Pyrrolidine-based Fragments That Sample Three-dimensional Molecular Space by Garner, Philip, Cox, Philip B, Rathnayake, Upendra, Holloran, Nicholas, Erdman, Paul

“…Fragment-based drug discovery (FBDD) is a well-established technology for lead compound generation in drug discovery. As this technology has evolved, the…”
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A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine by Scott, Kevin A, Qureshi, M. Haziq, Cox, Philip B, Marshall, Christopher M, Bellaire, Bailey C, Wilcox, Michael, Stuart, Bradey A. R, Njardarson, Jon T

“…The FDA Green Book is a list of all drug products that have been approved by the FDA for use in veterinary medicine. The Green Book, as published, lacks…”
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Escaping from Flatland: Substituted Bridged Pyrrolidine Fragments with Inherent Three-Dimensional Character by Cox, Brian, Zdorichenko, Victor, Cox, Philip B., Booker-Milburn, Kevin I., Paumier, Romain, Elliott, Luke D., Robertson-Ralph, Michael, Bloomfield, Graham

“…The pressure to deliver new medicines to the patient continues to grow along with increases in compound failure rate, thus putting the current R&D model at…”
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Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design by Dietrich, Justin D, Longenecker, Kenton L, Wilson, Noel S, Goess, Christian, Panchal, Sanjay C, Swann, Steven L, Petros, Andrew M, Hobson, Adrian D, Ihle, David, Song, Danying, Richardson, Paul, Comess, Kenneth M, Cox, Philip B, Dombrowski, Amanda, Sarris, Kathy, Donnelly-Roberts, Diana L, Duignan, David B, Gomtsyan, Arthur, Jung, Paul, Krueger, A Chris, Mathieu, Suzanne, McClure, Andrea, Stoll, Vincent S, Wetter, Jill, Mankovich, John A, Hajduk, Philip J, Vasudevan, Anil, Stoffel, Robert H, Sun, Chaohong

“…Tumor necrosis factor α (TNFα) is a soluble cytokine that is directly involved in systemic inflammation through the regulation of the intracellular NF-κB and…”
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Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection: Miniperspective by DeGoey, David A, Chen, Hui-Ju, Cox, Philip B, Wendt, Michael D

“…Recently, there has been an increasing focus on the pursuit of targets considered to be less druggable that offer potential for development of promising new…”
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Differential Expression of Prostaglandin E2 Receptors in Porcine Kidney Transplants by Harner, Andrew, Wang, Youli, Fang, Xuexiu, Merchen, Todd D., Cox, Philip B., Ho, Sam, Kleven, Daniel, Thompson, Thomas, Nahman, N. Stanley

“…Acute rejection of a kidney allograft results from adaptive immune responses and marked inflammation. The eicosanoid prostaglandin E2 (PGE2) modulates the…”
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Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches by Mochalkin, Igor, Miller, J. Richard, Narasimhan, Lakshmi, Thanabal, Venkataraman, Erdman, Paul, Cox, Philip B, Prasad, J. V. N. Vara, Lightle, Sandra, Huband, Michael D, Stover, C. Kendall

“…As part of our effort to inhibit bacterial fatty acid biosynthesis through the recently validated target biotin carboxylase, we employed a unique combination…”
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Use of Silicon-Based Tethers to Control Diastereofacial Selectivity in Azomethine Ylide Cycloadditions1 by Garner, Philip, Cox, Philip B, Anderson, James T, Protasiewicz, John, Zaniewski, Rebecca

“…A novel approach to controlling the diastereofacial selectivity of intramolecular dipolar cycloadditions of azomethine ylides (cf. 9 → 8) by varying the…”
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Development of an Effective Chiral Auxiliary for Hydroxyalkyl Radicals by Garner, Philip, Anderson, James T, Cox, Philip B, Klippenstein, Stephen J, Leslie, Ray, Scardovi, Noemi

“…The development of an effective chiral auxiliary for hydroxyalkyl radicals is delineated. Both the 2-tetrahydropyranyl (THP) and…”
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Use of Silicon-Based Tethers to Control Diastereofacial Selectivity in Azomethine Ylide Cycloadditions(1) by Garner, Philip, Cox, Philip B., Anderson, James T., Protasiewicz, John, Zaniewski, Rebecca

“…A novel approach to controlling the diastereofacial selectivity of intramolecular dipolar cycloadditions of azomethine ylides (cf. 9 --> 8) by varying the…”
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4,6-Dichloro-5-nitropyrimidine: a versatile building block for the solid phase synthesis of dihydropteridinones by Baxter, Anthony D, Boyd, E.Andrew, Cox, Philip B, Loh, Vincent, Monteils, Claude, Proud, Andrew

“…This letter describes a novel, flexible, solid phase route to pyrimidine-based heterocycles that utilises commercially available…”
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The solid phase synthesis of unsymmetrical phosphinic acids by Cox, Philip B, Loh, Vincent M, Monteils, Claude, Baxter, Anthony D, Boyd, E.Andrew

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Auxiliary Induced .rho.-Stereocontrol in Acetaloxyalkyl Radical Addition Reactions by Garner, Philip P, Cox, Philip B, Klippenstein, Stephen J

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