Search Results - "Cox, Peter J"

A Ketone Ester Drink Increases Postexercise Muscle Glycogen Synthesis in Humans by HOLDSWORTH, DAVID A, COX, PETER J, KIRK, TOM, STRADLING, HUW, IMPEY, SAMUEL G, CLARKE, KIERAN

“…INTRODUCTIONPhysical endurance can be limited by muscle glycogen stores, in that glycogen depletion markedly reduces external work. During carbohydrate…”
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Genome-wide association analysis of pain severity in dysmenorrhea identifies association at chromosome 1p13.2, near the nerve growth factor locus by Jones, Amy V., Hockley, James R.F., Hyde, Craig, Gorman, Donal, Sredic-Rhodes, Ana, Bilsland, James, McMurray, Gordon, Furlotte, Nicholas A., Hu, Youna, Hinds, David A., Cox, Peter J., Scollen, Serena

“…Dysmenorrhea is a common chronic pelvic pain syndrome affecting women of childbearing potential. Family studies suggest that genetic background influences the…”
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Functional confirmation that the R1488 variant in SCN9A results in complete loss-of-function of Nav1.7 by He, Wen, Young, Gareth T, Zhang, Baohong, Cox, Peter J, Cho, Lily Ting-Yin, John, Sally, Paciga, Sara A, Wood, Linda S, Danziger, Nicolas, Scollen, Serena, Vangjeli, Ciara

“…BackgroundIndividuals with an extremely rare inherited condition, termed Congenital Insensitivity to Pain (CIP), do not feel pain in response to noxious…”
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A rare case of mobile diplopodia mistaken for polydactyly by Woodacre, Timothy, Dunkerley, Sarah, Cox, Peter J

“…We present a rare case of a mobile diplopodia in an infant with disorganization syndrome. This was initially mistaken for polydactyly due to the more typical…”
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Ion Channels as Therapeutic Targets: A Drug Discovery Perspective by Bagal, Sharan K, Brown, Alan D, Cox, Peter J, Omoto, Kiyoyuki, Owen, Robert M, Pryde, David C, Sidders, Benjamin, Skerratt, Sarah E, Stevens, Edward B, Storer, R. Ian, Swain, Nigel A

“…Ion channels are membrane proteins expressed in almost all living cells. The sequencing of the human genome has identified more than 400 putative ion channels,…”
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CACHD1 is an α2δ-Like Protein That Modulates CaV3 Voltage-Gated Calcium Channel Activity by Cottrell, Graeme S, Soubrane, Camille H, Hounshell, James A, Lin, Hong, Owenson, Venetia, Rigby, Michael, Cox, Peter J, Barker, Bryan S, Ottolini, Matteo, Ince, Selvi, Bauer, Claudia C, Perez-Reyes, Edward, Patel, Manoj K, Stevens, Edward B, Stephens, Gary J

“…The putative cache (Ca 2+ channel and chemotaxis receptor) domain containing 1 (CACHD1) protein has predicted structural similarities to members of the α2δ…”
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Big Data in Drug Discovery by Brown, Nathan, Cambruzzi, Jean, Cox, Peter J, Davies, Mark, Dunbar, James, Plumbley, Dean, Sellwood, Matthew A, Sim, Aaron, Williams-Jones, Bryn I, Zwierzyna, Magdalena, Sheppard, David W

“…Interpretation of Big Data in the drug discovery community should enhance project timelines and reduce clinical attrition through improved early decision…”
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The Effect of Deletion of the Orphan G – Protein Coupled Receptor (GPCR) Gene MrgE on Pain-Like Behaviours in Mice by Cox, Peter J, Pitcher, Tom, Trim, Steven A, Bell, Christine H, Qin, Wenning, Kinloch, Ross A

“…Background: The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it…”
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CACHD1 is an α2δ-Like Protein That Modulates Ca V 3 Voltage-Gated Calcium Channel Activity by Cottrell, Graeme S, Soubrane, Camille H, Hounshell, James A, Lin, Hong, Owenson, Venetia, Rigby, Michael, Cox, Peter J, Barker, Bryan S, Ottolini, Matteo, Ince, Selvi, Bauer, Claudia C, Perez-Reyes, Edward, Patel, Manoj K, Stevens, Edward B, Stephens, Gary J

“…The putative cache (Ca channel and chemotaxis receptor) domain containing 1 (CACHD1) protein has predicted structural similarities to members of the α2δ…”
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The “Ischial Limb”: A Landmark on Anterior Ultrasound Scanning Used to Assess Reduction in Developmental Dysplasia of the Hip by Woodacre, Timothy, Carlile, Graeme S, Cox, Peter J

“…BACKGROUND:Early recognition of failure of reduction during abduction splinting in developmental dysplasia of the hip (DDH) is essential to avoid inappropriate…”
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Functional confirmation that the R1488 variant in SCN9A results in complete loss-of-function of Na v 1.7 by He, Wen, Young, Gareth T, Zhang, Baohong, Cox, Peter J, Cho, Lily Ting-Yin, John, Sally, Paciga, Sara A, Wood, Linda S, Danziger, Nicolas, Scollen, Serena, Vangjeli, Ciara

“…Individuals with an extremely rare inherited condition, termed Congenital Insensitivity to Pain (CIP), do not feel pain in response to noxious stimuli…”
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Discovery of a Series of Indazole TRPA1 Antagonists by Pryde, David C, Marron, Brian E, West, Christopher W, Reister, Steven, Amato, George, Yoger, Katrina, Antonio, Brett, Padilla, Karen, Cox, Peter J, Turner, Jamie, Warmus, Joseph S, Swain, Nigel A, Omoto, Kiyoyuki, Mahoney, John H, Gerlach, Aaron C

“…A series of TRPA1 antagonists is described which has as its core structure an indazole moiety. The physical properties and in vitro DMPK profiles are…”
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The Chimeric Approach Reveals That Differences in the TRPV1 Pore Domain Determine Species-specific Sensitivity to Block of Heat Activation by Papakosta, Marianthi, Dalle, Carine, Haythornthwaite, Alison, Cao, Lishuang, Stevens, Edward B., Burgess, Gillian, Russell, Rachel, Cox, Peter J., Phillips, Stephen C., Grimm, Christian

“…The capsaicin-, heat-, and proton-activated ion channel TRPV1, a member of the transient receptor potential cation channel family is a polymodal nociceptor…”
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β3: An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics by Morgan, Kevin, Stevens, Edward B., Shah, Bhaval, Cox, Peter J., Dixon, Alistair K., Lee, Kevin, Pinnock, Robert D., Hughes, John, Richardson, Peter J., Mizuguchi, Kenji, Jackson, Antony P.

“…The voltage-sensitive sodium channel confers electrical excitability on neurons, a fundamental property required for higher processes including cognition. The…”
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Absorption, Disposition, and Metabolism of Rosiglitazone, a Potent Thiazolidinedione Insulin Sensitizer, in Humans by COX, P. J, RYAN, D. A, HOLLIS, F. J, HARRIS, A.-M, MILLER, A. K, VOUSDEN, M, COWLEY, H

“…Rosiglitazone is a potent peroxisome proliferator-activated receptor gamma agonist that decreases hyperglycemia by reducing insulin resistance in patients with…”
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[ 3H] pregabalin binding is increased in ipsilateral dorsal horn following chronic constriction injury by Melrose, Heather L, Kinloch, Ross A, Cox, Peter J, Field, Mark J, Collins, David, Williams, Dic

“…Pregabalin, a 3-substituted analogue of gamma-amino butyric acid has recently been approved for treatment of neuropathic pain. We have investigated the…”
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New targets for neuropathic pain therapeutics by Kinloch, Ross A, Cox, Peter J

“…Neuropathic pain (NeP) is initiated by a lesion or dysfunction in the nervous system. Unlike physiological pain it serves no useful purpose and is usually…”
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A novel splice variant of the SUR1 in the CNS, showing low susceptibility to glibenclamide by Amagase, Yoko, Cox, Peter J., Takei, Yoshinori, Richardson, Peter J.

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Determination of Residues in the Norepinephrine Transporter That Are Critical for Tricyclic Antidepressant Affinity by Roubert, Christine, Cox, Peter J., Brüss, Michael, Hamon, Michel, Bönisch, Heinz, Giros, Bruno

“…The norepinephrine (NET) and dopamine (DAT) transporters are highly homologous proteins, displaying many pharmacological similarities. Both transport dopamine…”
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Obtaining an optimal bone-cement interface in total knee arthroplasty by Blake, Stephen M, Cox, Peter J

“…BACKGROUND Survival of a total knee arthroplasty is dependent on numerous factors including soft tissue balancing, limb alignment, implant choice, insertion…”
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