Search Results - "Cox, Manon M"

Age Dependence and Isotype Specificity of Influenza Virus Hemagglutinin Stalk-Reactive Antibodies in Humans by Nachbagauer, Raffael, Choi, Angela, Izikson, Ruvim, Cox, Manon M, Palese, Peter, Krammer, Florian

“…Influenza remains a major global health burden. Seasonal vaccines offer protection but can be rendered less effective when the virus undergoes extensive…”
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Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older by Dunkle, Lisa M, Izikson, Ruvim, Patriarca, Peter, Goldenthal, Karen L, Muse, Derek, Callahan, Janice, Cox, Manon M.J

“…Influenza epidemics cause substantial morbidity. The seasonal vaccine, an important control measure, is not completely efficacious. This trial assessed the…”
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Recombinant protein vaccines produced in insect cells by Cox, Manon M.J

“…Highlights ► BEVS has matured into a commercial manufacturing technology. ► A broad range of vaccines can be produced in a universal “plug and play” process. ►…”
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Technology transfer and scale-up of the Flublok® recombinant hemagglutinin (HA) influenza vaccine manufacturing process by Buckland, Barry, Boulanger, Robert, Fino, Mireli, Srivastava, Indresh, Holtz, Kathy, Khramtsov, Nikolai, McPherson, Clifton, Meghrous, Jamal, Kubera, Paul, Cox, Manon M.J

“…Highlights • Successful fivefold scale-up to 2500 L scale of first FDA licensed recombinant influenza vaccine. • FDA licensed process is reproducible for a…”
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Innovations in the Insect Cell Expression System for Industrial Recombinant Vaccine Antigen Production by Cox, Manon M J

“…The insect cell expression system has previously been proposed as the preferred biosecurity strategy for production of any vaccine, particularly for future…”
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Titer on chip: new analytical tool for influenza vaccine potency determination by Kuck, Laura R, Sorensen, Michelle, Matthews, Erin, Srivastava, Indresh, Cox, Manon M J, Rowlen, Kathy L

“…Titer on Chip (Flu-ToC) is a new technique for quantification of influenza hemagglutinin (HA) concentration. In order to evaluate the potential of this new…”
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Randomized clinical trial of immunogenicity and safety of a recombinant H1N1/2009 pandemic influenza vaccine containing Advax™ polysaccharide adjuvant by Gordon, David L, Sajkov, Dimitar, Woodman, Richard J, Honda-Okubo, Yoshikazu, Cox, Manon M.J, Heinzel, Susanne, Petrovsky, Nikolai

“…Highlights ► Randomized clinical trial of a novel adjuvanted H1N1/2009 pandemic influenza vaccine. ► Reports first pandemic use of a vaccine based on…”
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A fast track influenza virus vaccine produced in insect cells by Cox, Manon M.J., Hashimoto, Yoshifumi

“…[Display omitted] ► A recombinant hemagglutinin vaccine (FluBlok) is produced in insect cells. ► Characterization of cell substrate revealed no evidence of…”
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Pandemic influenza vaccine: characterization of A/California/07/2009 (H1N1) recombinant hemagglutinin protein and insights into H1N1 antigen stability by Feshchenko, Elena, Rhodes, David G, Felberbaum, Rachael, McPherson, Clifton, Rininger, Joseph A, Post, Penny, Cox, Manon M J

“…The recent H1N1 influenza pandemic illustrated the shortcomings of the vaccine manufacturing process. The A/California/07/2009 H1N1 pandemic influenza vaccine…”
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Vaccination with a Recombinant H7 Hemagglutinin-Based Influenza Virus Vaccine Induces Broadly Reactive Antibodies in Humans by Stadlbauer, Daniel, Rajabhathor, Arvind, Amanat, Fatima, Kaplan, Daniel, Masud, Abusaleh, Treanor, John J, Izikson, Ruvim, Cox, Manon M, Nachbagauer, Raffael, Krammer, Florian

“…Human influenza virus infections with avian subtype H7N9 viruses are a major public health concern and have encouraged the development of effective H7…”
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Randomized comparison of the safety of Flublok® versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥50 years of age by Izikson, Ruvim, Leffell, David J, Bock, S. Allan, Patriarca, Peter A, Post, Penny, Dunkle, Lisa M, Cox, Manon M.J

“…Abstract Background The safety and tolerability of Flublok® , a purified recombinant hemagglutinin seasonal influenza vaccine, was compared to AFLURIA® in a…”
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Dissolved carbon dioxide determines the productivity of a recombinant hemagglutinin component of an influenza vaccine produced by insect cells by Meghrous, Jamal, Khramtsov, Nikolai, Buckland, Barry C., Cox, Manon M.J., Palomares, Laura A., Srivastava, Indresh K.

“…ABSTRACT Dissolved carbon dioxide (dCO2) accumulation during cell culture has been recognized as an important parameter that needs to be controlled for…”
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Expression and purification of an influenza hemagglutinin—one step closer to a recombinant protein-based influenza vaccine by Wang, Keyang, Holtz, Kathleen M., Anderson, Karl, Chubet, Richard, Mahmoud, Wafaa, Cox, Manon M.J.

“…Numerous human infections with avian influenza viruses in Asia in recent years have raised the concern that the next influenza pandemic is imminent. The most…”
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Dose-Related Safety and Immunogenicity of a Trivalent Baculovirus-Expressed Influenza-Virus Hemagglutinin Vaccine in Elderly Adults by Treanor, John J., Schiff, Gilbert M., Couch, Robert B., Cate, Thomas R., Brady, Rebecca C., Hay, C. Mhorag, Wolff, Mark, She, Dewei, Cox, Manon M. J.

“…BackgroundInfluenza-virus hemagglutinin (HA) protein expressed in insect cells by recombinant baculovirus is a candidate influenza vaccine MethodsIn a…”
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Improved stability of recombinant hemagglutinin using a formulation containing sodium thioglycolate by Rhodes, David G, Holtz, Kathy, Robinson, Pam, Wang, Keyang, McPherson, Clifton E, Cox, Manon M.J, Srivastava, Indresh K

“…Abstract This study was designed to improve the stability of liquid formulations of recombinant influenza hemagglutinin (rHA) and to understand the mechanism…”
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FluBlok, a recombinant hemagglutinin influenza vaccine by Cox, Manon M.J., Patriarca, Peter A., Treanor, John

“…FluBlok, a recombinant trivalent hemagglutinin (HA) vaccine produced in insect cell culture using the baculovirus expression system, provides an attractive…”
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Panblok-H1+advax H1N1/2009pdm vaccine: Insights into rapid development of a delta inulin adjuvanted recombinant pandemic influenza vaccine by Honda-Okubo, Yoshikazu, Rajapaksha, Harinda, Sajkov, Dimitar, Gordon, David, Cox, Manon M. J., Petrovsky, Nikolai

“…Timely vaccine supply is critical during influenza pandemics but is impeded by current virus-based manufacturing methods. The 2009 H1N1/2009pdm 'swine flu'…”
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Evaluation of the Virus Counter ® for rapid baculovirus quantitation by Ferris, Matthew M., Stepp, Patricia C., Ranno, Kirk A., Mahmoud, Wafaa, Ibbitson, Elizabeth, Jarvis, James, Cox, Manon M.J., Christensen, Kurt, Votaw, Heather, Edwards, Dean P., Rowlen, Kathy L.

“…The utility of a new instrument for rapid virus quantitation, the Virus Counter, was evaluated in a blind study conducted at three sites. This instrument is a…”
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Expansion and Storage of Insect Cells and Virus Stocks by Cox, Manon M J

“…Healthy insect cell cultures are critical for any method described in this book, including making productive baculovirus banks, protein or AAV expression, and…”
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Safety, efficacy, and immunogenicity of Flublok in the prevention of seasonal influenza in adults by Cox, Manon M. J., Izikson, Ruvim, Post, Penny, Dunkle, Lisa

“…Flublok is the first recombinant hemagglutinin (HA) vaccine licensed by the US Food and Drugs Administration for the prevention of influenza in adults aged 18…”
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