Search Results - "Cox, Maggie J."

Comprehensive profiling of clinical JAK inhibitors in myeloproliferative neoplasms by Kong, Tim, Yu, LaYow, Laranjeira, Angelo B. A., Fisher, Daniel A. C., He, Fan, Cox, Maggie J., Oh, Stephen T.

“…Small molecule inhibitors targeting JAK2 provide symptomatic benefits for myeloproliferative neoplasm (MPN) patients and are among first‐line therapeutic…”
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A phase I trial of pevonedistat in combination with ruxolitinib for the treatment of myelofibrosis by Kong, Tim, Gaudin, Nicole, Gordon, Karyn, Cox, Maggie J, Zhou, Amy W, Oh, Stephen T

“…Janus kinase 2 (JAK2) inhibitors such as ruxolitinib have become standard-of-care therapy for patients with myeloproliferative neoplasms (MPNs); however,…”
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Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms by He, Fan, Laranjeira, Angelo Ba, Kong, Tim, Lin, Shuyang, Ashworth, Katrina J, Liu, Alice, Lasky, Nina M, Fisher, Daniel Ac, Cox, Maggie J, Fulbright, Mary C, Antunes-Heck, Lilian, Yu, LaYow, Brakhane, Molly, Gao, Bei, Sykes, Stephen M, D'Alessandro, Angelo, Di Paola, Jorge, Oh, Stephen T

“…Platelets from patients with myeloproliferative neoplasms (MPNs) exhibit a hyperreactive phenotype. Here, we found elevated P-selectin exposure and…”
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Spatial Mapping of Hematopoietic Clones in Human Bone Marrow by Young, Andrew L, Davis, Hannah C, Cox, Maggie J, Parsons, Tyler M, Burkart, Samantha C, Bender, Diane E, Sun, Lulu, Oh, Stephen T, Challen, Grant A

“…Clonal hematopoiesis (CH) is the expansion of somatically mutated cells in the hematopoietic compartment of individuals without hematopoietic dysfunction…”
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DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression by Kong, Tim, Laranjeira, Angelo B A, Yang, Kangning, Fisher, Daniel A C, Yu, LaYow, Poittevin De La Frégonnière, Laure, Wang, Anthony Z, Ruzinova, Marianna B, Fowles, Jared S, Fulbright, Mary C, Cox, Maggie J, Celik, Hamza, Challen, Grant A, Huang, Sidong, Oh, Stephen T

“…Myeloproliferative neoplasms (MPNs) exhibit a propensity for transformation to secondary acute myeloid leukemia (sAML), for which the underlying mechanisms…”
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Leukemic Driver Clones Can Arise Independently and Outcompete MPN Cells in Post-MPN Secondary AML by Parsons, Tyler M, Young, Andrew L, Fisher, Daniel A.C., Cox, Maggie J, Oh, Stephen T., Challen, Grant A

“…The JAK2V617F variant is an acquired somatic mutation recurrently found in myeloproliferative neoplasm (MPN) patients and is used as a diagnostic marker. While…”
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Methods to Elucidate Hematopoietic Clonal Organization in Bone Marrow by Young, Andrew L, Davis, Hannah C, Cox, Maggie J, Parsons, Tyler M, Burkart, Samantha C, Oh, Stephen T., Challen, Grant A

“…Every tissue in the human body becomes a mosaic of somatic mutations throughout life. Each cell in the body contains a record of the genetic alterations…”
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Galectin-1 Fuels Monocyte-Driven Hyperinflammation and Represents a Novel Therapeutic Target in Myeloproliferative Neoplasms by He, Fan, Kong, Tim, Lin, Shuyang, Fulbright, Mary C., Laranjeira, Angelo B. A., Fisher, Daniel A.C., Cox, Maggie J, Ashworth, Katrina, Di Paola, Jorge, Oh, Stephen T.

“…JDP and STO co-corresponding authors Previous studies by our group and others have demonstrated that monocytes play a key role in driving hyperinflammation in…”
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RSK1 Is an Exploitable Dependency in Myeloid Malignancies by Kong, Tim, Laranjeira, Angelo B. A., Yu, LaYow, Fowles, Jared Scott, Fisher, Daniel A.C., Ng, Sherwin, Yang, Wei, He, Fan, Cox, Maggie J, Fulbright, Mary C., Rentschler, Stacey L., Huynh, My-my, Los, Gerrit, Dunn, Sandra E., Challen, Grant A, Oh, Stephen T.

“…Myeloid malignancies harbor distinct molecular drivers but share convergence of oncogenic signaling pathways and propagation by ripe pro-inflammatory niches…”
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Multicenter Retrospective Analysis of Eosinophilic Myeloid Neoplasms by Molloy, Eoghan, Shomali, William, Cox, Maggie J, Butterfield, Joseph, Catherine, Julien, Deininger, Michael W., Gao, Juehua, Helbig, Grzegorz, Hobbs, Gabriela S., Jia, Fuli, Kahn, Jean Emmanuel, Khoury, Paneez, Komarow, Hirsh, Kuykendall, Andrew T., Leiva, Orly, Lefèvre, Guillaume, Lim, Hana I, Marcellino, Bridget, Maric, Irina, Mascarenhas, John, Mishchenko, Elena, Oh, Stephen T., Padron, Eric, Panch, Sandhya R, Patel, Ami, Perkins, Cecelia, Pongdee, Thanai, Roufosse, Florence, Schafer, Andrew I., Stein, Brady L., Verstovsek, Srdan, Wang, Sa A., Zhang, Ling, Gotlib, Jason, Klion, Amy D

“…Background. Some patients who present with clinical features consistent with idiopathic hypereosinophilic syndrome (HES; absolute eosinophil count (AEC) ≥1.5 x…”
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