Search Results - "Cox, Laura M."

Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences by Cox, Laura M., Yamanishi, Shingo, Sohn, Jiho, Alekseyenko, Alexander V., Leung, Jacqueline M., Cho, Ilseung, Kim, Sungheon G., Li, Huilin, Gao, Zhan, Mahana, Douglas, Zárate Rodriguez, Jorge G., Rogers, Arlin B., Robine, Nicolas, Loke, P’ng, Blaser, Martin J.

“…Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the…”
Get full text

Pathways in Microbe-Induced Obesity by Cox, Laura M., Blaser, Martin J.

“…Diet, host gene composition, and alterations in the intestinal microbiota can contribute to obesity. In microbe-induced obesity, metabolic changes stem from…”
Get full text

Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer by Dominguez-Bello, Maria G, De Jesus-Laboy, Kassandra M, Shen, Nan, Cox, Laura M, Amir, Amnon, Gonzalez, Antonio, Bokulich, Nicholas A, Song, Se Jin, Hoashi, Marina, Rivera-Vinas, Juana I, Mendez, Keimari, Knight, Rob, Clemente, Jose C

“…The microbiota of cesarean-born infants can be partially restored to that of vaginally born infants immediately after birth. Exposure of newborns to the…”
Get full text

Alterations of the human gut microbiome in multiple sclerosis by Jangi, Sushrut, Gandhi, Roopali, Cox, Laura M., Li, Ning, von Glehn, Felipe, Yan, Raymond, Patel, Bonny, Mazzola, Maria Antonietta, Liu, Shirong, Glanz, Bonnie L., Cook, Sandra, Tankou, Stephanie, Stuart, Fiona, Melo, Kirsy, Nejad, Parham, Smith, Kathleen, Topçuolu, Begüm D., Holden, James, Kivisäkk, Pia, Chitnis, Tanuja, De Jager, Philip L., Quintana, Francisco J., Gerber, Georg K., Bry, Lynn, Weiner, Howard L.

“…The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to…”
Get full text

The gut microbiota influences skeletal muscle mass and function in mice by Lahiri, Shawon, Kim, Hyejin, Garcia-Perez, Isabel, Reza, Musarrat Maisha, Martin, Katherine A, Kundu, Parag, Cox, Laura M, Selkrig, Joel, Posma, Joram M, Zhang, Hongbo, Padmanabhan, Parasuraman, Moret, Catherine, Gulyás, Balázs, Blaser, Martin J, Auwerx, Johan, Holmes, Elaine, Nicholson, Jeremy, Wahli, Walter, Pettersson, Sven

“…The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the…”
Get more information

Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila by Liu, Shirong, Rezende, Rafael M., Moreira, Thais G., Tankou, Stephanie K., Cox, Laura M., Wu, Meng, Song, Anya, Dhang, Fyonn H., Wei, Zhiyun, Costamagna, Gianluca, Weiner, Howard L.

“…Fecal transfer from healthy donors is being explored as a microbiome modality. MicroRNAs (miRNAs) have been found to affect the microbiome. Multiple sclerosis…”
Get full text

A probiotic modulates the microbiome and immunity in multiple sclerosis by Tankou, Stephanie K., Regev, Keren, Healy, Brian C., Tjon, Emily, Laghi, Luca, Cox, Laura M., Kivisäkk, Pia, Pierre, Isabelle V., Hrishikesh, Lokhande, Gandhi, Roopali, Cook, Sandra, Glanz, Bonnie, Stankiewicz, James, Weiner, Howard L.

“…Objective Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing‐remitting multiple sclerosis (MS)…”
Get full text

Gut Microbiome in Progressive Multiple Sclerosis by Cox, Laura M., Maghzi, Amir Hadi, Liu, Shirong, Tankou, Stephanie K., Dhang, Fyonn H., Willocq, Valerie, Song, Anya, Wasén, Caroline, Tauhid, Shahamat, Chu, Renxin, Anderson, Mark C., De Jager, Philip L., Polgar‐Turcsanyi, Mariann, Healy, Brian C., Glanz, Bonnie I., Bakshi, Rohit, Chitnis, Tanuja, Weiner, Howard L.

“…Objective This study was undertaken to investigate the gut microbiome in progressive multiple sclerosis (MS) and how it relates to clinical disease. Methods We…”
Get full text

Distinct Polysaccharide Utilization Profiles of Human Intestinal Prevotella copri Isolates by Fehlner-Peach, Hannah, Magnabosco, Cara, Raghavan, Varsha, Scher, Jose U., Tett, Adrian, Cox, Laura M., Gottsegen, Claire, Watters, Aaron, Wiltshire-Gordon, John D., Segata, Nicola, Bonneau, Richard, Littman, Dan R.

“…Gut-dwelling Prevotella copri (P. copri), the most prevalent Prevotella species in the human gut, have been associated with diet and disease. However, our…”
Get full text

Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses by Kienesberger, Sabine, Cox, Laura M., Livanos, Alexandra, Zhang, Xue-Song, Chung, Jennifer, Perez-Perez, Guillermo I., Gorkiewicz, Gregor, Zechner, Ellen L., Blaser, Martin J.

“…Helicobacter pylori is a late-in-life human pathogen with potential early-life benefits. Although H. pylori is disappearing from the human population, little…”
Get full text

Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment by Nobel, Yael R., Cox, Laura M., Kirigin, Francis F., Bokulich, Nicholas A., Yamanishi, Shingo, Teitler, Isabel, Chung, Jennifer, Sohn, Jiho, Barber, Cecily M., Goldfarb, David S., Raju, Kartik, Abubucker, Sahar, Zhou, Yanjiao, Ruiz, Victoria E., Li, Huilin, Mitreva, Makedonka, Alekseyenko, Alexander V., Weinstock, George M., Sodergren, Erica, Blaser, Martin J.

“…Mammalian species have co-evolved with intestinal microbial communities that can shape development and adapt to environmental changes, including antibiotic…”
Get full text

Investigation of probiotics in multiple sclerosis by Tankou, Stephanie K, Regev, Keren, Healy, Brian C, Cox, Laura M, Tjon, Emily, Kivisakk, Pia, Vanande, Isabelle P, Cook, Sandra, Gandhi, Roopali, Glanz, Bonnie, Stankiewicz, James, Weiner, Howard L

“…None of the disease-modifying therapies (DMTs) currently being used for the management of multiple sclerosis (MS) are 100% effective. In addition, side effects…”
Get full text

Helminth colonization is associated with increased diversity of the gut microbiota by Lee, Soo Ching, Tang, Mei San, Lim, Yvonne A L, Choy, Seow Huey, Kurtz, Zachary D, Cox, Laura M, Gundra, Uma Mahesh, Cho, Ilseung, Bonneau, Richard, Blaser, Martin J, Chua, Kek Heng, Loke, P'ng

“…Soil-transmitted helminths colonize more than 1.5 billion people worldwide, yet little is known about how they interact with bacterial communities in the gut…”
Get full text

Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males by Abou-El-Hassan, Hadi, Rezende, Rafael M., Izzy, Saef, Gabriely, Galina, Yahya, Taha, Tatematsu, Bruna K., Habashy, Karl J., Lopes, Juliana R., de Oliveira, Gislane L. V., Maghzi, Amir-Hadi, Yin, Zhuoran, Cox, Laura M., Krishnan, Rajesh, Butovsky, Oleg, Weiner, Howard L.

“…Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and adaptive immune responses play an important role in the pathogenesis…”
Get full text

Description of two novel members of the family Erysipelotrichaceae: Ileibacterium valens gen. nov., sp. nov. and Dubosiella newyorkensis, gen. nov., sp. nov., from the murine intestine, and emendation to the description of Faecalibacterium rodentium by Cox, Laura M, Sohn, Jiho, Tyrrell, Kerin L, Citron, Diane M, Lawson, Paul A, Patel, Nisha B, Iizumi, Tadasu, Perez-Perez, Guillermo I, Goldstein, Ellie J. C, Blaser, Martin J

“…To better characterize murine intestinal microbiota, a large number (187) of Gram-positive-staining, rod- and coccoid-shaped, and facultatively or strictly…”
Get full text

Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer’s disease mouse models by Wasén, Caroline, Beauchamp, Leah C., Vincentini, Julia, Li, Shuqi, LeServe, Danielle S., Gauthier, Christian, Lopes, Juliana R., Moreira, Thais G., Ekwudo, Millicent N., Yin, Zhuoran, da Silva, Patrick, Krishnan, Rajesh K., Butovsky, Oleg, Cox, Laura M., Weiner, Howard L.

“…The gut microbiota and microglia play critical roles in Alzheimer’s disease (AD), and elevated Bacteroides is correlated with cerebrospinal fluid amyloid-β…”
Get full text

The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis by Cox, Laura M, Calcagno, Narghes, Gauthier, Christian, Madore, Charlotte, Butovsky, Oleg, Weiner, Howard L

“…The gut microbiota can affect neurologic disease by shaping microglia, the primary immune cell in the central nervous system (CNS). While antibiotics improve…”
Get full text

PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis by Moreira, Thais G., Mangani, Davide, Cox, Laura M., Leibowitz, Jeffrey, Lobo, Eduardo. L. C., Oliveira, Mariana A., Gauthier, Christian D., Nakagaki, Brenda N., Willocq, Valerie, Song, Anya, Guo, Lydia, Lima, David C. A., Murugaiyan, Gopal, Butovsky, Oleg, Gabriely, Galina, Anderson, Ana C., Rezende, Rafael M., Faria, Ana Maria C., Weiner, Howard L.

“…The intestinal mucosa constitutes an environment of closely regulated immune cells. Dendritic cells (DC) interact with the gut microbiome and antigens and are…”
Get full text

Mining the microbiota to identify gut commensals modulating neuroinflammation in a mouse model of multiple sclerosis by Bianchimano, Paola, Britton, Graham J, Wallach, David S, Smith, Emma M, Cox, Laura M, Liu, Shirong, Iwanowski, Kacper, Weiner, Howard L, Faith, Jeremiah J, Clemente, Jose C, Tankou, Stephanie K

“…The gut microbiome plays an important role in autoimmunity including multiple sclerosis and its mouse model called experimental autoimmune encephalomyelitis…”
Get full text

Cognitive Effects of Simulated Galactic Cosmic Radiation Are Mediated by ApoE Status, Sex, and Environment in APP Knock-In Mice by Wieg, Laura, Ciola, Jason C, Wasén, Caroline C, Gaba, Fidelia, Colletti, Brianna R, Schroeder, Maren K, Hinshaw, Robert G, Ekwudo, Millicent N, Holtzman, David M, Saito, Takashi, Sasaguri, Hiroki, Saido, Takaomi C, Cox, Laura M, Lemere, Cynthia A

“…Cosmic radiation experienced during space travel may increase the risk of cognitive impairment. While simulated galactic cosmic radiation (GCRsim) has led to…”
Get full text