Search Results - "Cox, Eric D."

The Pictet-Spengler condensation: a new direction for an old reaction by Cox, Eric D, Cook, James M

“…Pictet-Spengler condensations in nonacidic aprotic media, modeling the pharmacophore of benzodiazepine receptor sites and indolamine 2,3-dioxygenase…”
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Unexpected Migration and Oxidative Cyclization of Substituted 2-Acetophenone Triflates under Basic Conditions:  Synthetic and Mechanistic Insights by Coe, Jotham W, Bianco, Krista E, Boscoe, Brian P, Brooks, Paige R, Cox, Eric D, Vetelino, Michael G

“…Oxidative ring closure of alkyl-substituted 2-hydroxyacetophenone trifluoromethanesulfonate esters (triflates) occurs upon exposure to base in anaerobic DMF at…”
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(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: Synthesis, in vitro, in vivo, and X-ray crystallographic characterization by Wright, Stephen W., Ammirati, Mark J., Andrews, Kim M., Brodeur, Anne M., Danley, Dennis E., Doran, Shawn D., Lillquist, Jay S., Liu, Shenping, McClure, Lester D., McPherson, R. Kirk, Olson, Thanh V., Orena, Stephen J., Parker, Janice C., Rocke, Benjamin N., Soeller, Walter C., Soglia, Carolyn B., Treadway, Judith L., VanVolkenburg, Maria A., Zhao, Zhengrong, Cox, Eric D.

“…Potency, selectivity, and pharmacokinetic properties of DPP-IV inhibitors developed from a HTS hit were optimized resulting in the identification of a…”
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The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells by BARBACCI, E. Gabriella, PUSTILNIK, Leslie R, KATH, John C, ZHENGYU LIU, MOYER, James D, ROSSI, Ann Marie K, EMERSON, Erling, MILLER, Penny E, BOSCOE, Brian P, COX, Eric D, IWATA, Kenneth K, JANI, Jitesh P, PROVONCHA, Kathleen

“…Aberrant expression or activity of epidermal growth factor receptor (EGFr) or the closely related p185(erbB2) can promote cell proliferation and survival and…”
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Enantiospecific Formation of Trans 1,3-Disubstituted Tetrahydro-β-carbolines by the Pictet−Spengler Reaction and Conversion of Cis Diastereomers into Their Trans Counterparts by Scission of the C-1/N-2 Bond by Cox, Eric D, Hamaker, Linda K, Li, Jin, Yu, Peng, Czerwinski, Kevin M, Deng, Li, Bennett, Dennis W, Cook, James M, Watson, William H, Krawiec, Mariusz

“…The factors which effect the stereoselective formation of trans-1-alkyl-2-benzyl-3-(alkoxycarbonyl)-1,2,3,4-tetrahydro-β-carbolines and…”
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Different types of GABAA receptors may mediate the anticonflict and response rate-decreasing effects of zaleplon, zolpidem, and midazolam in squirrel monkeys by PARONIS, Carol A, COX, Eric D, COOK, James M, BERGMAN, Jack

“…Rationale: The role of different types of GABAA receptors in mediating anticonflict and response rate-decreasing effects of benzodiazepines in primate species…”
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Achieving selectivity between highly homologous tyrosine kinases: a novel selective erbB2 inhibitor by Bhattacharya, Samit K., Cox, Eric D., Kath, John C., Mathiowetz, Alan M., Morris, Joel, Moyer, James D., Pustilnik, Leslie R., Rafidi, Kris, Richter, Daniel T., Su, Chunyan, Wessel, Matthew D.

“…The discovery of small molecule kinase inhibitors for use as drugs is a promising approach for the treatment of cancer and other diseases, but the discovery of…”
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Randomized trial of bilateral gene therapy injection for m.11778G>A MT-ND4 Leber optic neuropathy by Newman, Nancy J, Yu-Wai-Man, Patrick, Subramanian, Prem S, Moster, Mark L, Wang, An-Guor, Donahue, Sean P, Leroy, Bart P, Carelli, Valerio, Biousse, Valerie, Vignal-Clermont, Catherine, Sergott, Robert C, Sadun, Alfredo A, Rebolleda Fernández, Gema, Chwalisz, Bart K, Banik, Rudrani, Bazin, Fabienne, Roux, Michel, Cox, Eric D, Taiel, Magali, Sahel, José-Alain

“…Abstract Leber hereditary optic neuropathy (LHON) is an important example of mitochondrial blindness with the m.11778G>A mutation in the MT-ND4 gene being the…”
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Synthesis and Evaluation of Analogues of the Partial Agonist 6-(Propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic Acid Ethyl Ester (6-PBC) and the Full Agonist 6-(Benzyloxy)-4-(methoxymethyl)-β- carboline-3-carboxylic Acid Ethyl Ester (Zk 93423) at Wild Type and Recombinant GABAA Receptors by Cox, Eric D, Diaz-Arauzo, Hernando, Huang, Qi, Reddy, Mundla S, Ma, Chunrong, Harris, Brad, McKernan, Ruth, Skolnick, Phil, Cook, James M

“…A pharmacophore and an alignment rule have previously been reported for BzR agonist ligands. The design and synthesis of…”
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Synthesis and Evaluation of Analogues of the Partial Agonist 6-(Propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic Acid Ethyl Ester (6-PBC) and the Full Agonist 6-(Benzyloxy)-4-(methoxymethyl)-β- carboline-3-carboxylic Acid Ethyl Ester (Zk 93423) at Wild Type and Recombinant GABA A Receptors by Cox, Eric D., Diaz-Arauzo, Hernando, Huang, Qi, Reddy, Mundla S., Ma, Chunrong, Harris, Brad, McKernan, Ruth, Skolnick, Phil, Cook, James M.

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Mode of action of β-carboline convulsants on the insect nervous system and their potential as insecticides by Bloomquist, Jeffrey R., Ferguson, Holly J., Cox, Eric D., Reddy, M. Sreenivasa, Cook, James M.

“…Little information is available on the actions of β‐carboline convulsants on insect GABA receptors or their potential as insecticides. Accordingly, two…”
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Pannus Attack: Septic Thrombophlebitis by Cox, Eric R., MD, Amoroso, Anthony, MD, Gilliam, Bruce L., MD

“…Cox et al talk about septic thrombophlebitis, which is frequently recognized in the upper extremities and neck veins, often after insertion of a central venous…”
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Depression, Medical Illness, and Interleukin-1[beta] in Older Cardiac Patients by Lyness, Jeffrey M, Moynihan, Jan A, Williford, Daniel J, Cox, Christopher, Caine, Eric D

“…Objective: A model has been proposed in which atherosclerosis contributes to depression in later life by the effects of cytokines on central monoamine systems…”
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Anxiety and Functional Status in Older Primary Care Patients by Upadhyaya, Ajaya K., Lyness, Jeffrey M., Cox, Christopher, Seidlitz, Larry, Caine, Eric D.

“…Objective: The aim of this study was to test the hypothesis that anxiety in older primary care patients is associated with functional impairment after…”
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