Search Results - "Cox, Brian M"

Challenges for opioid receptor nomenclature: IUPHAR Review 9 by Cox, Brian M, Christie, Macdonald J, Devi, Lakshmi, Toll, Lawrence, Traynor, John R

“…Recent developments in the study of the structure and function of opioid receptors raise significant challenges for the definition of individual receptor types…”
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Histone Deacetylase Inhibition Rescues Maternal Deprivation-Induced GABAergic Metaplasticity through Restoration of AKAP Signaling by Authement, Michael E., Kodangattil, Jayaraj N., Gouty, Shawn, Rusnak, Milan, Symes, Aviva J., Cox, Brian M., Nugent, Fereshteh S.

“…Adverse early-life experiences such as child neglect and abuse increase the risk of developing addiction and stress-related disorders through alterations in…”
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Mass spectrometry imaging of rat brain lipid profile changes over time following traumatic brain injury by Roux, Aurelie, Muller, Ludovic, Jackson, Shelley N, Post, Jeremy, Baldwin, Katherine, Hoffer, Barry, Balaban, Carey D, Barbacci, Damon, Schultz, J. Albert, Gouty, Shawn, Cox, Brian M, Woods, Amina S.

“…•MSI allows the in situ mapping of molecules directly from tissues.•Brain images showed changes in most lipids classes 3 days after TBI.•Signaling lipids such…”
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Involvement of Lateral Habenula Dysfunction in Repetitive Mild Traumatic Brain Injury-Induced Motivational Deficits by Flerlage, William J, Langlois, Ludovic D, Rusnak, Milan, Simmons, Sarah C, Gouty, Shawn, Armstrong, Regina C, Cox, Brian M, Symes, Aviva J, Tsuda, Mumeko C, Nugent, Fereshteh S

“…Affective disorders including depression (characterized by reduced motivation, social withdrawal, and anhedonia), anxiety, and irritability are frequently…”
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Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula by Simmons, Sarah C., Shepard, Ryan D., Gouty, Shawn, Langlois, Ludovic D., Flerlage, William J., Cox, Brian M., Nugent, Fereshteh S.

“…The lateral habenula (LHb) is an epithalamic brain region associated with value-based decision making and stress evasion through its modulation of dopamine…”
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A-kinase anchoring protein-calcineurin signaling in long-term depression of GABAergic synapses by Dacher, Matthieu, Gouty, Shawn, Dash, Steven, Cox, Brian M, Nugent, Fereshteh S

“…The postsynaptic scaffolding A-kinase anchoring protein 79/150 (AKAP79/150) signaling complex regulates excitatory synaptic transmission and strength through…”
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A concise review of concepts in opioid pharmacology up to the discovery of endogenous opioids by Cox, Brian M

“…This brief review covers concepts in opioid pharmacology that were promoted during the period leading up to the establishment of the International Narcotics…”
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AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula by Simmons, Sarah C., Flerlage, William J., Langlois, Ludovic D., Shepard, Ryan D., Bouslog, Christopher, Thomas, Emily H., Gouty, Kaitlyn M., Sanderson, Jennifer L., Gouty, Shawn, Cox, Brian M., Dell’Acqua, Mark L., Nugent, Fereshteh S.

“…The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and…”
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Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems by Toll, Lawrence, Bruchas, Michael R, Calo', Girolamo, Cox, Brian M, Zaveri, Nurulain T

“…The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently discovered member of the opioid receptor family and, together with its…”
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Biased signaling by endogenous opioid peptides by Gomes, Ivone, Sierra, Salvador, Lueptow, Lindsay, Gupta, Achla, Gouty, Shawn, Margolis, Elyssa B., Cox, Brian M., Devi, Lakshmi A.

“…Opioids, such as morphine and fentanyl, are widely used for the treatment of severe pain; however, prolonged treatment with these drugs leads to the…”
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Recent developments in the study of opioid receptors by Cox, Brian M

“…It is now about 40 years since Avram Goldstein proposed the use of the stereoselectivity of opioid receptors to identify these receptors in neural membranes…”
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Differential protection against MPTP or methamphetamine toxicity in dopamine neurons by deletion of ppN/OFQ expression by Brown, Jeffrey M., Gouty, Shawn, Iyer, Varsha, Rosenberger, John, Cox, Brian M.

“…Nociceptin (N/OFQ) is an endogenous neuropeptide that plays a role in the behavioral deficits associated with Parkinson's disease (PD). The purpose of the…”
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Addressing the Opioid Crisis: Medical Student Instruction in Opioid Drug Pharmacology, Pain Management, and Substance Use Disorders by Cox, Brian M, Cote, Thomas E, Lucki, Irwin

“…The marked increase in deaths related to opioid drugs after 1999 was associated with an increase in the number of prescriptions for opioid drugs. This was…”
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Targeting histone deacetylation for recovery of maternal deprivation-induced changes in BDNF and AKAP150 expression in the VTA by Shepard, Ryan D., Gouty, Shawn, Kassis, Haifa, Berenji, Aylar, Zhu, William, Cox, Brian M., Nugent, Fereshteh S.

“…Severe early life stressors increase the probability of developing psychiatric disorders later in life through modifications in neuronal circuits controlling…”
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Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury by Flerlage, William J., Simmons, Sarah C., Thomas, Emily H., Gouty, Shawn, Cox, Brian M., Nugent, Fereshteh S.

“…Mild traumatic brain injury (mTBI) increases the risk of affective disorders, anxiety and substance use disorder. The lateral habenula (LHb) plays an important…”
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Aversive Stress Reduces Mu Opioid Receptor Expression in the Intercalated Nuclei of the Rat Amygdala by Gouty, Shawn, Silveira, Julia Tomoyasu, Cote, Thomas E., Cox, Brian M.

“…The amygdala plays an important role in the integration of responses to noxious and fearful stimuli. Sensory information from many systems is integrated in the…”
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Contributions of the International Narcotics Research Conference to Opioid Research Over the Past 50 years by Cox, Brian M, Toll, Lawrence

“…The International Narcotics Research Conference (INRC), founded in 1969, has been a successful forum for research into the actions of opiates, with an annual…”
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Distribution of nociceptin/orphanin FQ in adult human brain by Witta, Jassir, Palkovits, Miklos, Rosenberger, John, Cox, Brian M

“…Nociceptin/orphanin FQ (N/OFQ), the endogenous agonist for the opioid receptor-like receptor 1 (ORL1), shows significant similarities to dynorphin A in…”
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Development of a systems‐based in situ multiplex biomarker screening approach for the assessment of immunopathology and neural tissue plasticity in male rats after traumatic brain injury by Bogoslovsky, Tanya, Bernstock, Joshua D., Bull, Greg, Gouty, Shawn, Cox, Brian M., Hallenbeck, John M., Maric, Dragan

“…Traumatic brain injuries (TBIs) pose a massive burden of disease and continue to be a leading cause of morbidity and mortality throughout the world. A major…”
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Morphine-induced synaptic plasticity in the VTA is reversed by HDAC inhibition by Authement, Michael E, Langlois, Ludovic D, Kassis, Haifa, Gouty, Shawn, Dacher, Matthieu, Shepard, Ryan D, Cox, Brian M, Nugent, Fereshteh S

“…Dopamine (DA) dysfunction originating from the ventral tegmental area (VTA) occurs as a result of synaptic abnormalities following consumption of drugs of…”
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