Search Results - "Cox, Benoit"

Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability by Boretto, Matteo, Cox, Benoit, Noben, Manuel, Hendriks, Nikolai, Fassbender, Amelie, Roose, Heleen, Amant, Frédéric, Timmerman, Dirk, Tomassetti, Carla, Vanhie, Arne, Meuleman, Christel, Ferrante, Marc, Vankelecom, Hugo

“…The endometrium, which is of crucial importance for reproduction, undergoes dynamic cyclic tissue remodeling. Knowledge of its molecular and cellular…”
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Regeneration in the Pituitary After Cell-Ablation Injury: Time-Related Aspects and Molecular Analysis by Willems, Christophe, Fu, Qiuli, Roose, Heleen, Mertens, Freya, Cox, Benoit, Chen, Jianghai, Vankelecom, Hugo

“…We recently showed that the mouse pituitary holds regenerative competence. Young-adult GHCre/iDTR mice, expressing diphtheria toxin (DT) receptor in…”
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Organoids from pituitary as a novel research model toward pituitary stem cell exploration by Cox, Benoit, Laporte, Emma, Vennekens, Annelies, Kobayashi, Hiroto, Nys, Charlotte, Van Zundert, Indra, Uji-i, Hiroshi, Vercauteren Drubbel, Alizée, Beck, Benjamin, Roose, Heleen, Boretto, Matteo, Vankelecom, Hugo

“…The pituitary is the master endocrine gland, harboring stem cells of which the phenotype and role remain poorly characterized. Here, we established organoids…”
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Pituitary stem cell regulation: who is pulling the strings? by Cox, Benoit, Roose, Heleen, Vennekens, Annelies, Vankelecom, Hugo

“…The pituitary gland plays a pivotal role in the endocrine system, steering fundamental processes of growth, metabolism, reproduction and coping with stress…”
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Decoding the activated stem cell phenotype of the neonatally maturing pituitary by Laporte, Emma, Hermans, Florian, De Vriendt, Silke, Vennekens, Annelies, Lambrechts, Diether, Nys, Charlotte, Cox, Benoit, Vankelecom, Hugo

“…The pituitary represents the endocrine master regulator. In mouse, the gland undergoes active maturation immediately after birth. Here, we in detail portrayed…”
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Setup of human liver-chips integrating 3D models, microwells and a standardized microfluidic platform as proof-of-concept study to support drug evaluation by Cox, Benoit, Barton, Patrick, Class, Reiner, Coxhead, Hannah, Delatour, Claude, Gillent, Eric, Henshall, Jamie, Isin, Emre M., King, Lloyd, Valentin, Jean-Pierre

“…•Microwells allow combining up to 100 human primary liver spheroids in one system.•The model is set up in a 96-well (liver-plate) and microfluidic format…”
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Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening by Boretto, Matteo, Maenhoudt, Nina, Luo, Xinlong, Hennes, Aurélie, Boeckx, Bram, Bui, Bich, Heremans, Ruben, Perneel, Lisa, Kobayashi, Hiroto, Van Zundert, Indra, Brems, Hilde, Cox, Benoit, Ferrante, Marc, Uji-i, Hiroshi, Koh, Kian Peng, D’Hooghe, Thomas, Vanhie, Arne, Vergote, Ignace, Meuleman, Christel, Tomassetti, Carla, Lambrechts, Diether, Vriens, Joris, Timmerman, Dirk, Vankelecom, Hugo

“…Endometrial disorders represent a major gynaecological burden. Current research models fail to recapitulate the nature and heterogeneity of these diseases,…”
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The role of the efflux transporter, P‐glycoprotein, at the blood–brain barrier in drug discovery by Cox, Benoit, Nicolaï, Johan, Williamson, Beth

“…The blood–brain barrier (BBB) expresses a high abundance of transporters, particularly P‐glycoprotein (P‐gp), that regulate endogenous and exogenous molecule…”
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Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland by Vennekens, Annelies, Laporte, Emma, Hermans, Florian, Cox, Benoit, Modave, Elodie, Janiszewski, Adrian, Nys, Charlotte, Kobayashi, Hiroto, Malengier-Devlies, Bert, Chappell, Joel, Matthys, Patrick, Garcia, Marie-Isabelle, Pasque, Vincent, Lambrechts, Diether, Vankelecom, Hugo

“…Stem cells in the adult pituitary are quiescent yet show acute activation upon tissue injury. The molecular mechanisms underlying this reaction are completely…”
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Major depletion of SOX2+ stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling by Roose, Heleen, Cox, Benoit, Boretto, Matteo, Gysemans, Conny, Vennekens, Annelies, Vankelecom, Hugo

“…The pituitary gland contains SOX2-expressing stem cells. However, their functional significance remains largely unmapped. We investigated their importance by…”
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Developing Organoids from Ovarian Cancer as Experimental and Preclinical Models by Maenhoudt, Nina, Defraye, Charlotte, Boretto, Matteo, Jan, Ziga, Heremans, Ruben, Boeckx, Bram, Hermans, Florian, Arijs, Ingrid, Cox, Benoit, Van Nieuwenhuysen, Els, Vergote, Ignace, Van Rompuy, Anne-Sophie, Lambrechts, Diether, Timmerman, Dirk, Vankelecom, Hugo

“…Ovarian cancer (OC) represents the most dismal gynecological cancer. Pathobiology is poorly understood, mainly due to lack of appropriate study models…”
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Extirpation of Atlantic Cod from a Northwest Atlantic ecosystem in the absence of predator control: inference from an ecosystem model of intermediate complexity by Rossi, Steven P, Benoît, Sean P. Cox. Hugues P

“…Atlantic cod (Gadus morhua) in the southern Gulf of St. Lawrence (sGSL) declined to low abundance in the early 1990s and have since failed to recover due to…”
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