Search Results - "Cox, Andrew G."

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling by Cox, Andrew G, Winterbourn, Christine C, Hampton, Mark B

“…Prxs (peroxiredoxins) are a family of proteins that are extremely effective at scavenging peroxides. The Prxs exhibit a number of intriguing properties that…”
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β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis by Rosenbluh, Joseph, Nijhawan, Deepak, Cox, Andrew G., Li, Xingnan, Neal, James T., Schafer, Eric J., Zack, Travis I., Wang, Xiaoxing, Tsherniak, Aviad, Schinzel, Anna C., Shao, Diane D., Schumacher, Steven E., Weir, Barbara A., Vazquez, Francisca, Cowley, Glenn S., Root, David E., Mesirov, Jill P., Beroukhim, Rameen, Kuo, Calvin J., Goessling, Wolfram, Hahn, William C.

“…Wnt/β-catenin signaling plays a key role in the pathogenesis of colon and other cancers; emerging evidence indicates that oncogenic β-catenin regulates several…”
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The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration by Cox, Andrew G, Goessling, Wolfram

“…The liver is an essential organ that plays a pivotal role in metabolism, digestion and nutrient storage. Major efforts have been made to develop zebrafish (…”
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Mitochondrial dysfunction remodels one-carbon metabolism in human cells by Bao, Xiaoyan Robert, Ong, Shao-En, Goldberger, Olga, Peng, Jun, Sharma, Rohit, Thompson, Dawn A, Vafai, Scott B, Cox, Andrew G, Marutani, Eizo, Ichinose, Fumito, Goessling, Wolfram, Regev, Aviv, Carr, Steven A, Clish, Clary B, Mootha, Vamsi K

“…Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from rare, inborn errors of metabolism to common, age-associated diseases…”
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Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth by Cox, Andrew G., Hwang, Katie L., Brown, Kristin K., Evason, Kimberley J., Beltz, Sebastian, Tsomides, Allison, O’Connor, Keelin, Galli, Giorgio G., Yimlamai, Dean, Chhangawala, Sagar, Yuan, Min, Lien, Evan C., Wucherpfennig, Julia, Nissim, Sahar, Minami, Akihiro, Cohen, David E., Camargo, Fernando D., Asara, John M., Houvras, Yariv, Stainier, Didier Y. R., Goessling, Wolfram

“…The Hippo pathway is an important regulator of organ size and tumorigenesis. It is unclear, however, how Hippo signalling provides the cellular building blocks…”
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Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk by Grimm, Lin, Nakajima, Hiroyuki, Chaudhury, Smrita, Bower, Neil I, Okuda, Kazuhide S, Cox, Andrew G, Harvey, Natasha L, Koltowska, Katarzyna, Mochizuki, Naoki, Hogan, Benjamin M

“…Lymphatic vascular development involves specification of lymphatic endothelial progenitors that subsequently undergo sprouting, proliferation and tissue growth…”
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Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo by Harris, James M., Esain, Virginie, Frechette, Gregory M., Harris, Lauren J., Cox, Andrew G., Cortes, Mauricio, Garnaas, Maija K., Carroll, Kelli J., Cutting, Claire C., Khan, Tahsin, Elks, Philip M., Renshaw, Stephen A., Dickinson, Bryan C., Chang, Christopher J., Murphy, Michael P., Paw, Barry H., Vander Heiden, Matthew G., Goessling, Wolfram, North, Trista E.

“…Many pathways regulating blood formation have been elucidated, yet how each coordinates with embryonic biophysiology to modulate the spatiotemporal production…”
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Measuring the redox state of cellular peroxiredoxins by immunoblotting by Cox, Andrew G, Winterbourn, Christine C, Hampton, Mark B

“…The peroxiredoxins (Prxs) are a family of thiol peroxidases that scavenge hydroperoxides and peroxynitrite. The abundance and reactivity of these proteins…”
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Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins by Cox, Andrew G, Pearson, Andree G, Pullar, Juliet M, Jönsson, Thomas J, Lowther, W Todd, Winterbourn, Christine C, Hampton, Mark B

“…The Prxs (peroxiredoxins) are a family of cysteine-dependent peroxidases that decompose hydrogen peroxide. Prxs become hyperoxidized when a sulfenic acid…”
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Redox Potential and Peroxide Reactivity of Human Peroxiredoxin 3 by Cox, Andrew G, Peskin, Alexander V, Paton, Louise N, Winterbourn, Christine C, Hampton, Mark B

“…Peroxiredoxins (Prxs) are a ubiquitous family of thiol peroxidases that protect cells from peroxides and have a putative role in redox signaling. In this…”
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S-Nitrosothiol Signaling Regulates Liver Development and Improves Outcome following Toxic Liver Injury by Cox, Andrew G., Saunders, Diane C., Kelsey, Peter B., Conway, Allie A., Tesmenitsky, Yevgenia, Marchini, Julio F., Brown, Kristin K., Stamler, Jonathan S., Colagiovanni, Dorothy B., Rosenthal, Gary J., Croce, Kevin J., North, Trista E., Goessling, Wolfram

“…Toxic liver injury is a leading cause of liver failure and death because of the organ’s inability to regenerate amidst massive cell death, and few therapeutic…”
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Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis by Cox, Andrew G., Pullar, Juliet M., Hughes, Gillian, Ledgerwood, Elizabeth C., Hampton, Mark B.

“…It is hypothesized that activation of death receptors disrupts the redox homeostasis of cells and that this contributes to the induction of apoptosis. The…”
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Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity by Zhang, Yang, Guillermier, Christelle, De Raedt, Thomas, Cox, Andrew G., Maertens, Ophelia, Yimlamai, Dean, Lun, Mingyue, Whitney, Adam, Maas, Richard L., Goessling, Wolfram, Cichowski, Karen, Steinhauser, Matthew L.

“…Malignant tumors exhibit high degrees of genomic heterogeneity at the cellular level, leading to the view that subpopulations of tumor cells drive growth and…”
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Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3 by Peskin, Alexander V, Cox, Andrew G, Nagy, Péter, Morgan, Philip E, Hampton, Mark B, Davies, Michael J, Winterbourn, Christine C

“…Prxs (peroxiredoxins) are a ubiquitous family of cysteine-dependent peroxidases that react rapidly with H2O2 and alkyl hydroperoxides and provide defence…”
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Development of a hepatic cryoinjury model to study liver regeneration by Sande-Melon, Marcos, Bergemann, David, Fernández-Lajarín, Miriam, González-Rosa, Juan Manuel, Cox, Andrew G

“…The liver is a remarkable organ that can regenerate in response to injury. Depending on the extent of injury, the liver can undergo compensatory hyperplasia or…”
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YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth by Vaidyanathan, Srimayee, Salmi, Talhah M., Sathiqu, Rasan M., McConville, Malcolm J., Cox, Andrew G., Brown, Kristin K.

“…The coordinated regulation of growth control and metabolic pathways is required to meet the energetic and biosynthetic demands associated with proliferation…”
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YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow by Lundin, Vanessa, Sugden, Wade W., Theodore, Lindsay N., Sousa, Patricia M., Han, Areum, Chou, Stephanie, Wrighton, Paul J., Cox, Andrew G., Ingber, Donald E., Goessling, Wolfram, Daley, George Q., North, Trista E.

“…Hematopoietic stem and progenitor cells (HSPCs), first specified from hemogenic endothelium (HE) in the ventral dorsal aorta (VDA), support lifelong…”
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Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes by Chaturantabut, Saireudee, Shwartz, Arkadi, Evason, Kimberley J., Cox, Andrew G., Labella, Kyle, Schepers, Arnout G., Yang, Song, Acuña, Mariana, Houvras, Yariv, Mancio-Silva, Liliana, Romano, Shannon, Gorelick, Daniel A., Cohen, David E., Zon, Leonard I., Bhatia, Sangeeta N., North, Trista E., Goessling, Wolfram

“…Patients with cirrhosis are at high risk for hepatocellular carcinoma (HCC) and often have increased serum levels of estrogen. It is not clear how estrogen…”
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Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth by Cox, Andrew G, Tsomides, Allison, Yimlamai, Dean, Hwang, Katie L, Miesfeld, Joel, Galli, Giorgio G, Fowl, Brendan H, Fort, Michael, Ma, Kimberly Y, Sullivan, Mark R, Hosios, Aaron M, Snay, Erin, Yuan, Min, Brown, Kristin K, Lien, Evan C, Chhangawala, Sagar, Steinhauser, Matthew L, Asara, John M, Houvras, Yariv, Link, Brian, Vander Heiden, Matthew G, Camargo, Fernando D, Goessling, Wolfram

“…The Hippo pathway and its nuclear effector Yap regulate organ size and cancer formation. While many modulators of Hippo activity have been identified, little…”
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The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis by Ong, Athena Jessica S, Bladen, Cerys E, Tigani, Tara A, Karamalakis, Anthony P, Evason, Kimberley J, Brown, Kristin K, Cox, Andrew G

“…The maintenance of redox and metabolic homeostasis is integral to embryonic development. Nuclear factor erythroid 2-related factor 2 (NRF2) is a stress-induced…”
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