Search Results - "Cox, Andrea"

Approaches, Progress, and Challenges to Hepatitis C Vaccine Development by Bailey, Justin R., Barnes, Eleanor, Cox, Andrea L.

“…Risk factors for hepatitis C virus (HCV) infection vary, and there were an estimated 1.75 million new cases worldwide in 2015. The World Health Organization…”
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Challenges and Promise of a Hepatitis C Virus Vaccine by Cox, Andrea L

“…An estimated 1.5-2 million new hepatitis C virus (HCV) infections occur globally each year. Critical to the World Health Organization's (WHO) HCV elimination…”
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Progress towards elimination goals for viral hepatitis by Cox, Andrea L., El-Sayed, Manal H., Kao, Jia-Horng, Lazarus, Jeffrey V., Lemoine, Maud, Lok, Anna S., Zoulim, Fabien

“…The global burden of viral hepatitis is substantial; in terms of mortality, hepatitis B virus and hepatitis C virus infections are on a par with HIV, malaria…”
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Balancing Research, Teaching, Clinical Care, and Family: Can Physician-Scientists Have it All? by Cox, Andrea L

“…Unprecedented opportunities for research into basic biologic mechanisms, novel diagnostic approaches and therapies, population and outcomes medicine, health…”
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Herpes simplex virus type 1 inflammasome activation in proinflammatory human macrophages is dependent on NLRP3, ASC, and caspase-1 by Karaba, Andrew H, Figueroa, Alexis, Massaccesi, Guido, Botto, Sara, DeFilippis, Victor R, Cox, Andrea L

“…The proinflammatory cytokines interleukin (IL)-1β and IL-18 are products of activation of the inflammasome, an innate sensing system, and important in the…”
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Innovations Toward Immunopeptidomics by Abelin, Jennifer G., Cox, Andrea L.

“…Over the past 30 years, immunopeptidomics has grown alongside improvements in mass spectrometry technology, genomics, transcriptomics, T cell receptor…”
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HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon by Chattergoon, Michael A, Latanich, Rachel, Quinn, Jeffrey, Winter, Matthew E, Buckheit, 3rd, Robert W, Blankson, Joel N, Pardoll, Drew, Cox, Andrea L

“…Innate immune sensing of viral infection results in type I interferon (IFN) production and inflammasome activation. Type I IFNs, primarily IFN-α and IFN-β, are…”
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The BNT162b2 mRNA Vaccine Elicits Robust Humoral and Cellular Immune Responses in People Living With Human Immunodeficiency Virus (HIV) by Woldemeskel, Bezawit A, Karaba, Andrew H, Garliss, Caroline C, Beck, Evan J, Wang, Kristy H, Laeyendecker, Oliver, Cox, Andrea L, Blankson, Joel N

“…Abstract Previous studies have shown that certain vaccines induce suboptimal responses in people living with human immunodeficiency virus (HIV, PLWH). However,…”
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Randomized Trial of a Vaccine Regimen to Prevent Chronic HCV Infection by Page, Kimberly, Melia, Michael T, Veenhuis, Rebecca T, Winter, Matthew, Rousseau, Kimberly E, Massaccesi, Guido, Osburn, William O, Forman, Michael, Thomas, Elaine, Thornton, Karla, Wagner, Katherine, Vassilev, Ventzislav, Lin, Lan, Lum, Paula J, Giudice, Linda C, Stein, Ellen, Asher, Alice, Chang, Soju, Gorman, Richard, Ghany, Marc G, Liang, T. Jake, Wierzbicki, Michael R, Scarselli, Elisa, Nicosia, Alfredo, Folgori, Antonella, Capone, Stefania, Cox, Andrea L

“…In this trial, the safety and efficacy of a recombinant chimpanzee adenovirus 3 vector priming vaccination and a recombinant modified vaccinia Ankara boost was…”
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Markers of endothelial cell activation are associated with the severity of pulmonary disease in COVID-19 by Osburn, William O, Smith, Kimberly, Yanek, Lisa, Amat-Alcaron, Nuria, Thiemann, David R, Cox, Andrea L, Leucker, Thorsten M, Lowenstein, Charles J

“…Severe coronavirus disease-19 (COVID-19) is characterized by vascular inflammation and thrombosis. We and others have proposed that the inflammatory response…”
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Immunological Monitoring in Hepatitis C Virus Controlled Human Infection Model by Shoukry, Naglaa H, Cox, Andrea L, Walker, Christopher M

“…Abstract Controlled human infection model trials for hepatitis C virus represent an important opportunity to identify correlates of protective immunity against…”
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Controlled Human Infection Model — Fast Track to HCV Vaccine? by Liang, T. Jake, Feld, Jordan J, Cox, Andrea L, Rice, Charles M

“…The moratorium on experimentation with chimpanzees has impeded the progress of research on a vaccine against hepatitis C virus. Given the availability of…”
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Can Broadly Neutralizing Monoclonal Antibodies Lead to a Hepatitis C Virus Vaccine? by Kinchen, Valerie J., Cox, Andrea L., Bailey, Justin R.

“…While licensed vaccines elicit protective antibody responses against a variety of viral infections, an effective vaccine for hepatitis C virus (HCV) has…”
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Hepatitis C virus clearance, reinfection, and persistence, with insights from studies of injecting drug users: towards a vaccine by Grebely, Jason, Dr, Prins, Maria, Prof, Hellard, Margaret, Prof, Cox, Andrea L, Prof, Osburn, William O, PhD, Lauer, Georg, MD, Page, Kimberly, PhD, Lloyd, Andrew R, Prof, Dore, Gregory J, Prof

“…Summary Hepatitis C virus (HCV) was discovered more than two decades ago, but progress towards a vaccine has been slow. HCV infection will spontaneously clear…”
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Metabolic programs define dysfunctional immune responses in severe COVID-19 patients by Thompson, Elizabeth A., Cascino, Katherine, Ordonez, Alvaro A., Zhou, Weiqiang, Vaghasia, Ajay, Hamacher-Brady, Anne, Brady, Nathan R., Sun, Im-Hong, Wang, Rulin, Rosenberg, Avi Z., Delannoy, Michael, Rothman, Richard, Fenstermacher, Katherine, Sauer, Lauren, Shaw-Saliba, Kathyrn, Bloch, Evan M., Redd, Andrew D., Tobian, Aaron A.R., Horton, Maureen, Smith, Kellie, Pekosz, Andrew, D’Alessio, Franco R., Yegnasubramanian, Srinivasan, Ji, Hongkai, Cox, Andrea L., Powell, Jonathan D.

“…It is unclear why some SARS-CoV-2 patients readily resolve infection while others develop severe disease. By interrogating metabolic programs of immune cells…”
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TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer by Park, Benjamin V, Freeman, Zachary T, Ghasemzadeh, Ali, Chattergoon, Michael A, Rutebemberwa, Alleluiah, Steigner, Jordana, Winter, Matthew E, Huynh, Thanh V, Sebald, Suzanne M, Lee, Se-Jin, Pan, Fan, Pardoll, Drew M, Cox, Andrea L

“…Programmed death-1 (PD-1) is a coinhibitory receptor that downregulates the activity of tumor-infiltrating lymphocytes (TIL) in cancer and of virus-specific T…”
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Lessons from Nature: Understanding Immunity to HCV to Guide Vaccine Design by Freeman, Zachary T, Cox, Andrea L

“…Humans who have previously cleared a primary infection go on to resolve subsequent infections 83% of the time [14]. [...]these individuals have decreased viral…”
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Durable SARS-CoV-2 B cell immunity after mild or severe disease by Ogega, Clinton O, Skinner, Nicole E, Blair, Paul W, Park, Han-Sol, Littlefield, Kirsten, Ganesan, Abhinaya, Dhakal, Santosh, Ladiwala, Pranay, Antar, Annukka Ar, Ray, Stuart C, Betenbaugh, Michael J, Pekosz, Andrew, Klein, Sabra L, Manabe, Yukari C, Cox, Andrea L, Bailey, Justin R

“…Multiple studies have shown loss of severe acute respiratory syndrome coronavirus 2-specific (SARS-CoV-2-specific) antibodies over time after infection,…”
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Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses by Osburn, William O., Snider, Anna E., Wells, Brittany L., Latanich, Rachel, Bailey, Justin R., Thomas, David L., Cox, Andrea L., Ray, Stuart C.

“…The contribution of humoral immune responses to spontaneous control of hepatitis C virus (HCV) infection remains unclear. We assessed neutralizing antibody…”
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Differential Cytokine Signatures of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Influenza Infection Highlight Key Differences in Pathobiology by Karaba, Andrew H, Zhou, Weiqiang, Hsieh, Leon L, Figueroa, Alexis, Massaccesi, Guido, Rothman, Richard E, Fenstermacher, Katherine Z J, Sauer, Lauren, Shaw-Saliba, Kathryn, Blair, Paul W, Robinson, Matthew L, Leung, Sherry, Wesson, Russell, Alachkar, Nada, El-Diwany, Ramy, Ji, Hongkai, Cox, Andrea L

“…Abstract Background Several inflammatory cytokines are upregulated in severe coronavirus disease 2019 (COVID-19). We compared cytokines in COVID-19 versus…”
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