Search Results - "Cowley, Thelma R"

Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli by Barrett, James P, Costello, Derek A, O'Sullivan, Joan, Cowley, Thelma R, Lynch, Marina A

“…Lipopolysaccharide (LPS) and interferon-γ (IFNγ) increase expression of tumour necrosis factor-α (TNFα) that characterizes the M1 activation state of…”
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The Neuroprotective Effect of a Specific P2X7 Receptor Antagonist Derives from its Ability to Inhibit Assembly of the NLRP3 Inflammasome in Glial Cells by Murphy, Niamh, Cowley, Thelma R., Richardson, Jill C., Virley, David, Upton, Neil, Walter, Daryl, Lynch, Marina A.

“…Release of interleukin (IL)‐1β from immunocompetent cells requires formation of the NACHT, LLR and PYD domains‐containing protein 3 (NLRP3) inflammasome and…”
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The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation by Murphy, Niamh, Cowley, Thelma R, Blau, Christoph W, Dempsey, Colin N, Noonan, Janis, Gowran, Aoife, Tanveer, Riffat, Olango, Weredeselam M, Finn, David P, Campbell, Veronica A, Lynch, Marina A

“…Several factors contribute to the deterioration in synaptic plasticity which accompanies age and one of these is neuroinflammation. This is characterized by…”
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The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability by Blau, Christoph W, Cowley, Thelma R, O'Sullivan, Joan, Grehan, Belinda, Browne, Tara C, Kelly, Laura, Birch, Amy, Murphy, Niamh, Kelly, Aine M, Kerskens, Christian M, Lynch, Marina A

“…Abstract In view of the increase in the aging population and the unavoidable parallel increase in the incidence of age-related neurodegenerative diseases, a…”
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Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP by Cowley, Thelma R, O'Sullivan, Joan, Blau, Christoph, Deighan, Brian F, Jones, Raasay, Kerskens, Christian, Richardson, Jill C, Virley, David, Upton, Neil, Lynch, Marina A

“…Abstract Neuroinflammation is a significant and consistent feature of many neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's…”
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Age-related changes in the hippocampus (loss of synaptophysin and glial–synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL by Ojo, Bunmi, Rezaie, Payam, Gabbott, Paul L, Davies, Heather, Colyer, Frances, Cowley, Thelma R, Lynch, Marina, Stewart, Michael G

“…Highlight ► Hippocampal age-related reductions in astrocyte–synaptic contacts, and increases in microglia–synaptic contacts were attenuated using the NCAM…”
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A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL by Downer, Eric J, Cowley, Thelma R, Lyons, Anthony, Mills, Kingston H.G, Berezin, Vladimir, Bock, Elisabeth, Lynch, Marina A

“…Abstract Age-related cognitive deficits in hippocampus are correlated with neuroinflammatory changes, typified by increased pro-inflammatory cytokine…”
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The impact of glial activation in the aging brain by Lynch, Aileen M, Murphy, Kevin J, Deighan, Brian F, O'Reilly, Julie-Ann, Gun'ko, Yuri K, Cowley, Thelma R, Gonzalez-Reyes, Rodrigo E, Lynch, Marina A

“…The past decade or so has witnessed a rekindling of interest in glia requiring a re-evaluation of the early descriptions of astrocytes as merely support cells,…”
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synthetic NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory properties via IGF-1 and interferon-γ modulation by Downer, Eric J, Cowley, Thelma R, Cox, Fionnuala, Maher, Francis O, Berezin, Vladimir, Bock, Elisabeth, Lynch, Marina A

“…Microglial cell activity increases in the rat hippocampus during normal brain aging. The neural cell adhesion molecule (NCAM)-derived mimetic peptide, FG loop…”
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The Age-related Gliosis and Accompanying Deficit in Spatial Learning are Unaffected by Dimebon by Cowley, Thelma R., González-Reyes, Rodrigo Esteban, Richardson, Jill C., Virley, David, Upton, Neil, Lynch, Marina A.

“…A non-selective antihistamine, dimebon, has recently emerged as a potential treatment for Alzheimer’s disease and Huntington’s disease. Dimebon exerts several…”
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An NCAM Mimetic, FGL, Alters Hippocampal Cellular Morphometry in Young Adult (4 Month-Old) Rats by Ojo, Bunmi, Gabbott, Paul L., Rezaie, Payam, Corbett, Nicola, Medvedev, Nikolay I., Cowley, Thelma R., Lynch, Marina A., Stewart, Michael G.

“…The neural cell adhesion molecule, NCAM, is ubiquitously expressed within the CNS and has roles in development, cognition, neural plasticity and regulation of…”
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A cell adhesion molecule mimetic, FGL peptide, induces alterations in synapse and dendritic spine structure in the dentate gyrus of aged rats: a three-dimensional ultrastructural study by Popov, Victor I., Medvedev, Nikolay I., Kraev, Igor V., Gabbott, Paul L., Davies, Heather A., Lynch, Marina, Cowley, Thelma R., Berezin, Vladimir, Bock, Elisabeth, Stewart, Michael G.

“…The FGL peptide is a neural cell adhesion molecule (NCAM) mimetic comprising a 15‐amino‐acid‐long sequence of the FG loop region of the second fibronectin type…”
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The effect of the PPAR gamma agonist rosiglitazone on age-related changes in grey matter magnetic resonance relaxometry in the rat by Blau, Christoph W, Cowley, Thelma R, O'Sullivan, Joan B, Jones, Raasay S, Kerskens, Christian M, Lynch, Marina A

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The effect of the PPAR gamma agonist rosiglitazone on age-related changes in grey matter magnetic resonance relaxometry in the rat by Blau, Christoph W, Cowley, Thelma R, O'Sullivan, Joan B, Jones, Raasay S, Kerskens, Christian M, Lynch, Marina A

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Interleukin-1α and HMGB1 Mediate Hippocampal Dysfunction in SIGIRR-Deficient Mice by Costello, Derek A., Watson, Melanie B., Cowley, Thelma R., Murphy, Niamh, Murphy Royal, Ciarán, Garlanda, Cecilia, Lynch, Marina A.

“…Single-Ig-interleukin-1 related receptor (SIGIRR) is a member of the interleukin (IL)-1/Toll-like receptor (TLR) family. It negatively regulates inflammation,…”
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The Neuroprotective Effect of a Specific P2X 7 Receptor Antagonist Derives from its Ability to Inhibit Assembly of the NLRP3 Inflammasome in Glial Cells by Murphy, Niamh, Cowley, Thelma R., Richardson, Jill C., Virley, David, Upton, Neil, Walter, Daryl, Lynch, Marina A.

“…Abstract Release of interleukin (IL)‐1β from immunocompetent cells requires formation of the NACHT, LLR and PYD domains‐containing protein 3 (NLRP3)…”
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A synthetic NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory properties via IGF-1 and interferon-[gamma] modulation by Downer, Eric J, Cowley, Thelma R, Cox, Fionnuala, Maher, Francis O, Berezin, Vladimir, Bock, Elisabeth, Lynch, Marina A

“…Microglial cell activity increases in the rat hippocampus during normal brain aging. The neural cell adhesion molecule (NCAM)-derived mimetic peptide, FG loop…”
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P4‐166: CD200Fc fusion protein alleviates beta amyloid‐induced glial‐activation and neurodegeneration in vitro and in vivo by Cowley, Thelma R., Miller, Anne‐Marie, Piazza, Alessia, Downer, Eric J., Lynch, Marina A.

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CD200Fc fusion protein alleviates beta amyloid-induced glial-activation and neurodegeneration in vitro and in vivo by Cowley, Thelma R, Miller, Anne-Marie, Piazza, Alessia, Downer, Eric J, Lynch, Marina A

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IC‐P‐005: The effect of the PPAR gamma agonist rosiglitazone on age‐related changes in grey matter magnetic resonance relaxometry in the rat by Blau, Christoph W., Cowley, Thelma R., O'Sullivan, Joan B., Jones, Raasay S., Kerskens, Christian M., Lynch, Marina A.

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