Search Results - "Cowley, MA"

The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis by Cone, RD, Cowley, MA, Butler, AA, Fan, W, Marks, DL, Low, MJ

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Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis by Dhillon, Harveen, Zigman, Jeffrey M., Ye, Chianping, Lee, Charlotte E., McGovern, Robert A., Tang, Vinsee, Kenny, Christopher D., Christiansen, Lauryn M., White, Ryan D., Edelstein, Elisabeth A., Coppari, Roberto, Balthasar, Nina, Cowley, Michael A., Chua, Streamson, Elmquist, Joel K., Lowell, Bradford B.

“…Leptin, an adipocyte-derived hormone, acts directly on the brain to control food intake and energy expenditure. An important question is the identity of…”
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Gut hormone PYY3-36 physiologically inhibits food intake by BATTERHAM, Rachel L, COWLEY, Michael A, CONE, Roger D, BLOOM, Stephen R, SMALL, Caroline J, HERZOG, Herbert, COHEN, Mark A, DAKIN, Catherine L, WREN, Alison M, BRYNES, Audrey E, LOW, Malcolm J, GHATEI, Mohammad A

“…Peptide YY3-36 (PYY3-36), a Y2R agonist, is released from the gastrointestinal tract postpradially in proporation to the calorie content of a meal. Batterham…”
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The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis by Cone, R D, Cowley, M A, Butler, A A, Fan, W, Marks, D L, Low, M J

“…Arcuate nucleus neurons are known to be responsive to a wide array of hormones and nutrients, including leptin, insulin, gonadal steroids and glucose. In…”
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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus by Diano, Sabrina, Horvath, Tamas L, Smart, James L, Cowley, Michael A, Cone, Roger D, Low, Malcolm J, Rubinstein, Marcelo, Cerdán, Marcelo G

“…The administration of leptin to leptin-deficient humans, and the analogous Lepob/Lepob mice, effectively reduces hyperphagia and obesity. But common obesity is…”
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The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis by Cowley, Michael A, Smith, Roy G, Diano, Sabrina, Tschöp, Matthias, Pronchuk, Nina, Grove, Kevin L, Strasburger, Christian J, Bidlingmaier, Martin, Esterman, Michael, Heiman, Mark L, Garcia-Segura, Luis Miguel, Nillni, Eduardo A, Mendez, Pablo, Low, Malcolm J, Sotonyi, Peter, Friedman, Jeffrey M, Liu, Hongyan, Pinto, Shirly, Colmers, William F, Cone, Roger D, Horvath, Tamas L

“…The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via hypothalamic actions. We discovered expression of ghrelin in a…”
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Peptide YY Is a Regulator of Energy Homeostasis in Obese Children before and after Weight Loss by Roth, Christian L., Enriori, Pablo J., Harz, Katia, Woelfle, Joachim, Cowley, Michael A., Reinehr, Thomas

“…Context: The gut hormone peptide YY3–36 (PYY) reduces food intake via hypothalamic Y2 receptors in the brain. There is not much known about PYY in obese…”
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Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus: Evidence of a Cellular Basis for the Adipostat by Cowley, Michael A., Pronchuk, Nina, Fan, Wei, Dinulescu, Daniela M., Colmers, William F., Cone, Roger D.

“…Energy stores are held relatively constant in many mammals. The circuitry necessary for maintaining energy homeostasis should (1) sense the amount of energy…”
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Activation of Central Melanocortin Pathways by Fenfluramine by Heisler, Lora K., Cowley, Michael A., Tecott, Laurence H., Fan, Wei, Low, Malcolm J., Smart, James L., Rubinstein, Marcelo, Tatro, Jeffrey B., Marcus, Jacob N., Holstege, Henne, Lee, Charlotte E., Cone, Roger D., Elmquist, Joel K.

“…D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of…”
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The electrophysiology of feeding circuits by Jobst, Erin E., Enriori, Pablo J., Cowley, Michael A.

“…Obesity is quickly becoming one of the most common and debilitating disorders of the developed world. More than 60% of American adults are now overweight or…”
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Hypothalamic melanocortin neurons integrate signals of energy state by Cowley, Michael A.

“…Neurons of the arcuate nucleus of the hypothalamus appear to be sites of convergence of central and peripheral signals of energy stores, and profoundly…”
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Paradoxical Effect of Gonadotrophin-Inhibiting Hormone to Negatively Regulate Neuropeptide Y Neurones in Mouse Arcuate Nucleus by Jacobi, J. S., Coleman, H. A., Enriori, P. J., Parkington, H. C., Li, Q., Pereira, A., Cowley, M. A., Clarke, I. J.

“…Regulation of reproduction and energy homeostasis are linked, although our understanding of the central neural mechanisms subserving this connection is…”
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Is ghrelin a signal for the development of metabolic systems? by Grove, Kevin L, Cowley, Michael A

“…Ghrelin, produced in the stomach, acts on growth hormone secretagogue receptors (GHSRs) in hypothalamic neurons to potently increase food intake. However, male…”
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Ghrelin—Satisfying a Hunger for the Mechanism by Cowley, Michael A, Grove, Kevin L

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Electrophysiological Actions of Peripheral Hormones on Melanocortin Neurons by COWLEY, MICHAEL A., CONE, ROGER D., ENRIORI, PABLO, LOUISELLE, INGRID, WILLIAMS, SARAH M., EVANS, ANNE E.

“…: Neurons of the arcuate nucleus of the hypothalamus (ARH) appear to be sites of convergence of central and peripheral signals of energy stores, and profoundly…”
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Peptide YY(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques by KOEGLER, Frank H, ENRIORI, Pablo J, BILLES, Sonja K, TAKAHASHI, Diana L, MARTIN, Meghan S, CLARK, Randall L, EVANS, Anne E, GROVE, Kevin L, CAMERON, Judy L, COWLEY, Michael A

“…Peptide YY (3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques Frank H. Koegler 1 2 , Pablo J. Enriori 1 , Sonja…”
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Central Serotonin and Melanocortin Pathways Regulating Energy Homeostasis by HEISLER, LORA K., COWLEY, MICHAEL A., KISHI, TOSHIRO, TECOTT, LAURENCE H., FAN, WEI, LOW, MALCOLM J., SMART, JAMES L., RUBINSTEIN, MARCELO, TATRO, JEFFREY B., ZIGMAN, JEFFREY M., CONE, ROGER D., ELMQUIST, JOEL K.

“…: It is now established that the hypothalamus is essential in coordinating endocrine, autonomic, and behavioral responses to changes in energy availability…”
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The role of pharmacotherapy in the prevention and treatment of paediatric metabolic syndrome--Implications for long-term health: part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni by Sabin, M A, Magnussen, C G, Juonala, M, Cowley, M A, Shield, J P H

“…The metabolic syndrome (MetS) is defined as a clustering of risk factors predisposing to the future development of cardiovascular disease and Type 2 diabetes…”
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Coenzyme Q Induces Nigral Mitochondrial Uncoupling and Prevents Dopamine Cell Loss in a Primate Model of Parkinson’s Disease by Horvath, Tamas L, Diano, Sabrina, Leranth, Csaba, Garcia-Segura, Luis Miguel, Cowley, Michael A, Shanabrough, Marya, Elsworth, John D, Sotonyi, Peter, Roth, Robert H, Dietrich, Edwin H, Matthews, Russel T, Barnstable, Colin J, Redmond, D. Eugene

“…Parkinson’s disease is characterized by dopamine cell loss of the substantia nigra. Parkinson’s disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6…”
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Hypothalamic circuitry of neuropeptide Y regulation of neuroendocrine function and food intake via the Y5 receptor subtype by Campbell, R E, ffrench-Mullen, J M, Cowley, M A, Smith, M S, Grove, K L

“…Neuropeptide Y (NPY) displays diverse modes of action in the CNS including the modulation of feeding behavior, gonadotropin releasing hormone release, and…”
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