Search Results - "Cowley, M."

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates by Millard, Christopher J., Watson, Peter J., Celardo, Ivana, Gordiyenko, Yuliya, Cowley, Shaun M., Robinson, Carol V., Fairall, Louise, Schwabe, John W.R.

“…Class I histone deacetylases (HDAC1, HDAC2, and HDAC3) are recruited by cognate corepressor proteins into specific transcriptional repression complexes that…”
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Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex by Adams, Grace E, Chandru, Aditya, Cowley, Shaun M

“…At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-repressor complex, that is, a multi-protein complex recruited to…”
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Short‐term high‐fat diet increases the presence of astrocytes in the hypothalamus of C57BL6 mice without altering leptin sensitivity by Balland, E., Cowley, M. A.

“…Diet‐induced obesity is associated with hypothalamic inflammation and this phenomenon has been proposed to explain leptin resistance. In the present study, we…”
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The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts by Kelly, Richard D W, Cowley, Shaun M

“…HDACs (histone deacetylases) 1 and 2 are ubiquitous long-lived proteins, which are often found together in three major multiprotein co-repressor complexes:…”
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Enhancer decommissioning by LSD1 during embryonic stem cell differentiation by Whyte, Warren A., Bilodeau, Steve, Orlando, David A., Hoke, Heather A., Frampton, Garrett M., Foster, Charles T., Cowley, Shaun M., Young, Richard A.

“…In embryonic stem cells, the histone demethylase LSD1 occupies the enhancers of active genes and, together with the NuRD complex, decommissions the enhancers…”
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Bifunctional HDAC Therapeutics: One Drug to Rule Them All? by Smalley, Joshua P, Cowley, Shaun M, Hodgkinson, James T

“…Histone deacetylase (HDAC) enzymes play crucial roles in epigenetic gene expression and are an attractive therapeutic target. Five HDAC inhibitors have been…”
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Insights into the activation mechanism of class I HDAC complexes by inositol phosphates by Watson, Peter J., Millard, Christopher J., Riley, Andrew M., Robertson, Naomi S., Wright, Lyndsey C., Godage, Himali Y., Cowley, Shaun M., Jamieson, Andrew G., Potter, Barry V. L., Schwabe, John W. R.

“…Histone deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large transcriptional repression complexes. Unexpectedly, the enzymatic activity…”
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Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation by Dovey, Oliver M, Foster, Charles T, Cowley, Shaun M

“…Histone deacetylases (HDAC) 1 and 2 are highly similar enzymes that help regulate chromatin structure as the core catalytic components of corepressor…”
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OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation by Simandi, Zoltan, Horvath, Attila, Wright, Lyndsey C., Cuaranta-Monroy, Ixchelt, De Luca, Isabella, Karolyi, Katalin, Sauer, Sascha, Deleuze, Jean-Francois, Gudas, Lorraine J., Cowley, Shaun M., Nagy, Laszlo

“…Cell type specification relies on the capacity of undifferentiated cells to properly respond to specific differentiation-inducing signals. Using genomic…”
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Breastmilk-Saliva Interactions Boost Innate Immunity by Regulating the Oral Microbiome in Early Infancy by Al-Shehri, Saad S, Knox, Christine L, Liley, Helen G, Cowley, David M, Wright, John R, Henman, Michael G, Hewavitharana, Amitha K, Charles, Bruce G, Shaw, Paul N, Sweeney, Emma L, Duley, John A

“…Xanthine oxidase (XO) is distributed in mammals largely in the liver and small intestine, but also is highly active in milk where it generates hydrogen…”
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The composition of Australian Plantago seeds highlights their potential as nutritionally-rich functional food ingredients by Cowley, James M., O’Donovan, Lisa A., Burton, Rachel A.

“…When wetted, Plantago seeds become covered with a polysaccharide-rich gel called mucilage that has value as a food additive and bulking dietary fibre…”
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The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure by Turnbull, Robert E., Fairall, Louise, Saleh, Almutasem, Kelsall, Emma, Morris, Kyle L., Ragan, T. J., Savva, Christos G., Chandru, Aditya, Millard, Christopher J., Makarova, Olga V., Smith, Corinne J., Roseman, Alan M., Fry, Andrew M., Cowley, Shaun M., Schwabe, John W. R.

“…MiDAC is one of seven distinct, large multi-protein complexes that recruit class I histone deacetylases to the genome to regulate gene expression. Despite…”
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Industrial hemp seed: from the field to value-added food ingredients by Burton, Rachel A, Andres, Mike, Cole, Martin, Cowley, James M, Augustin, Mary Ann

“…Industrial hemp, with low levels of the intoxicating cannabinoid tetrahydrocannabinol (THC), is grown for fibre and seeds. The industrial hemp industry is…”
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THE MYC/MAX/MAD NETWORK AND THE TRANSCRIPTIONAL CONTROL OF CELL BEHAVIOR by Grandori, Carla, Cowley, Shaun M, James, Leonard P, Eisenman, Robert N

“…The Myc/Max/Mad network comprises a group of transcription factors whose distinct interactions result in gene-specific transcriptional activation or…”
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Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells by Jamaladdin, Shereen, Kelly, Richard D. W., O'Regan, Laura, Dovey, Oliver M., Hodson, Grace E., Millard, Christopher J., Portolano, Nicola, Fry, Andrew M., Schwabe, John W. R., Cowley, Shaun M.

“…Histone deacetylases 1 and 2 (HDAC1/2) form the core catalytic components of corepressor complexes that modulate gene expression. In most cell types, deletion…”
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Ghrelin by Müller, T.D, Nogueiras, R, Andermann, M.L, Andrews, Z.B, Anker, S.D, Argente, J, Batterham, R.L, Benoit, S.C, Bowers, C.Y, Broglio, F, Casanueva, F.F, D'Alessio, D, Depoortere, I, Geliebter, A, Ghigo, E, Cole, P.A, Cowley, M, Cummings, D.E, Dagher, A, Diano, S, Dickson, S.L, Diéguez, C, Granata, R, Grill, H.J, Grove, K, Habegger, K.M, Heppner, K, Heiman, M.L, Holsen, L, Holst, B, Inui, A, Jansson, J.O, Kirchner, H, Korbonits, M, Laferrère, B, LeRoux, C.W, Lopez, M, Morin, S, Nakazato, M, Nass, R, Perez-Tilve, D, Pfluger, P.T, Schwartz, T.W, Seeley, R.J, Sleeman, M, Sun, Y, Sussel, L, Tong, J, Thorner, M.O, van der Lely, A.J, van der Ploeg, L.H.T, Zigman, J.M, Kojima, M, Kangawa, K, Smith, R.G, Horvath, T, Tschöp, M.H

“…Abstract Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor…”
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The use of instability to train the core musculature by Behm, David G, Drinkwater, Eric J, Willardson, Jeffrey M, Cowley, Patrick M

“…Training of the trunk or core muscles for enhanced health, rehabilitation, and athletic performance has received renewed emphasis. Instability resistance…”
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SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer by Harris, N L E, Vennin, C, Conway, J R W, Vine, K L, Pinese, M, Cowley, M J, Shearer, R F, Lucas, M C, Herrmann, D, Allam, A H, Pajic, M, Morton, J P, Biankin, A V, Ranson, M, Timpson, P, Saunders, D N

“…Pancreatic cancer has a devastating prognosis, with an overall 5-year survival rate of ~8%, restricted treatment options and characteristic molecular…”
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Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability by Foster, Charles T., Dovey, Oliver M., Lezina, Larissa, Luo, Jin Li, Gant, Timothy W., Barlev, Nick, Bradley, Allan, Cowley, Shaun M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A rapid RT-LAMP SARS-CoV-2 screening assay for collapsing asymptomatic COVID-19 transmission by Allsopp, Rebecca C, Cowley, Caroline M, Barber, Ruth C, Jones, Carolyn, Holmes, Christopher W, Bird, Paul W, Gohil, Shailesh G, Blackmore, Claire, Tobin, Martin D, Brunskill, Nigel, Baker, Philip N, Shaw, Jacqui A

“…To demonstrate the diagnostic performance of rapid SARS-CoV-2 RT-LAMP assays, comparing the performance of genomic versus sub-genomic sequence target with…”
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