Search Results - "Cowen, Stephen L."

Mitigating the Effects of Electrode Biofouling-Induced Impedance for Improved Long-Term Electrochemical Measurements In Vivo by Seaton, Blake T, Hill, Daniel F, Cowen, Stephen L, Heien, Michael L

“…Biofouling is a prevalent issue in studies that involve prolonged implantation of electrochemical probes in the brain. In long-term fast-scan cyclic…”
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Preclinical evidence in support of repurposing sub-anesthetic ketamine as a treatment for L-DOPA-induced dyskinesia by Bartlett, Mitchell J., Flores, Andrew J., Ye, Tony, Smidt, Saskia I., Dollish, Hannah K., Stancati, Jennifer A., Farrell, Drew C., Parent, Kate L., Doyle, Kristian P., Besselsen, David G., Heien, Michael L., Cowen, Stephen L., Steece-Collier, Kathy, Sherman, Scott J., Falk, Torsten

“…Parkinson's disease (PD) is the second most common neurodegenerative disease. Pharmacotherapy with L-DOPA remains the gold-standard therapy for PD, but is…”
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Cortical kappa opioid receptors integrate negative affect and sleep disturbance by Lillo Vizin, Robson C., Ito, Hisakatsu, Kopruszinski, Caroline M., Ikegami, Megumi, Ikegami, Daigo, Yue, Xu, Navratilova, Edita, Moutal, Aubin, Cowen, Stephen L., Porreca, Frank

“…Sleep disruption and negative affect are attendant features of many psychiatric and neurological conditions that are often co-morbid including major depressive…”
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Ten-Hour Exposure to Low-Dose Ketamine Enhances Corticostriatal Cross-Frequency Coupling and Hippocampal Broad-Band Gamma Oscillations by Ye, Tony, Bartlett, Mitchell J, Schmit, Matthew B, Sherman, Scott J, Falk, Torsten, Cowen, Stephen L

“…Treatment-resistant depression, post-traumatic stress disorder, chronic pain, and L-DOPA-induced dyskinesia in Parkinson's disease are characterized by…”
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Early Intervention via Stimulation of the Medial Septal Nucleus Improves Cognition and Alters Markers of Epileptogenesis in Pilocarpine-Induced Epilepsy by Izadi, Ali, Schedlbauer, Amber, Ondek, Katelynn, Disse, Gregory, Ekstrom, Arne D, Cowen, Stephen L, Shahlaie, Kiarash, Gurkoff, Gene G

“…Over one-third of patients with temporal lobe epilepsy are refractory to medication. In addition, anti-epileptic drugs often exacerbate cognitive…”
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Recovery of Theta Frequency Oscillations in Rats Following Lateral Fluid Percussion Corresponds With a Mild Cognitive Phenotype by Ondek, Katelynn, Pevzner, Aleksandr, Tercovich, Kayleen, Schedlbauer, Amber M, Izadi, Ali, Ekstrom, Arne D, Cowen, Stephen L, Shahlaie, Kiarash, Gurkoff, Gene G

“…Whether from a fall, sports concussion, or even combat injury, there is a critical need to identify when an individual is able to return to play or work…”
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Phase Precession in Hippocampal Interneurons Showing Strong Functional Coupling to Individual Pyramidal Cells by Maurer, Andrew P, Cowen, Stephen L, Burke, Sara N, Barnes, Carol A, McNaughton, Bruce L

“…Although hippocampal interneurons typically do not show discrete regions of elevated firing in an environment, such as seen in pyramidal cell place fields,…”
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Sleep Spindles and Fragmented Sleep as Prodromal Markers in a Preclinical Model of LRRK2-G2019S Parkinson's Disease by Crown, Lindsey M., Bartlett, Mitchell J., Wiegand, Jean-Paul L., Eby, Allison J., Monroe, Emily J., Gies, Kathleen, Wohlford, Luke, Fell, Matthew J., Falk, Torsten, Cowen, Stephen L.

“…Sleep disturbances co-occur with and precede the onset of motor symptoms in Parkinson's disease (PD). We evaluated sleep fragmentation and thalamocortical…”
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Organization of hippocampal cell assemblies based on theta phase precession by Maurer, Andrew P., Cowen, Stephen L., Burke, Sara N., Barnes, Carol A., McNaughton, Bruce L.

“…The factors that control the spatial tuning of hippocampal neurons are incompletely understood, and there is no generally agreed upon definition of what…”
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Spectral signatures of L-DOPA-induced dyskinesia depend on L-DOPA dose and are suppressed by ketamine by Ye, Tony, Bartlett, Mitchell J., Sherman, Scott J., Falk, Torsten, Cowen, Stephen L.

“…L-DOPA-induced dyskinesias (LID) are debilitating motor symptoms of dopamine-replacement therapy for Parkinson's disease (PD) that emerge after years of L-DOPA…”
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Anterior cingulate neurons in the rat map anticipated effort and reward to their associated action sequences by Cowen, Stephen L, Davis, Glen A, Nitz, Douglas A

“…Goal-directed behaviors require the consideration and expenditure of physical effort. The anterior cingulate cortex (ACC) appears to play an important role in…”
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REM sleep in naps differentially relates to memory consolidation in typical preschoolers and children with Down syndrome by Spanò, Goffredina, Gómez, Rebecca L., Demara, Bianca I., Alt, Mary, Cowen, Stephen L., Edgin, Jamie O.

“…Sleep is recognized as a physiological state associated with learning, with studies showing that knowledge acquisition improves with naps. Little work has…”
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Aged Rats Exhibit Altered Behavior-Induced Oscillatory Activity, Place Cell Firing Rates, and Spatial Information Content in the CA1 Region of the Hippocampus by Crown, Lindsey M, Gray, Daniel T, Schimanski, Lesley A, Barnes, Carol A, Cowen, Stephen L

“…Hippocampal gamma and theta oscillations are associated with mnemonic and navigational processes and adapt to changes in the behavioral state of an animal to…”
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Dopamine Release Dynamics in the Nucleus Accumbens Are Modulated by the Timing of Electrical Stimulation Pulses When Applied to the Medial Forebrain Bundle and Medial Prefrontal Cortex by Hamilton, Andrea R., Vishwanath, Abhilasha, Weintraub, Nathan C., Cowen, Stephen L., Heien, M. Leandro

“…Electrical brain stimulation has been used in vivo and in vitro to investigate neural circuitry. Historically, stimulation parameters such as amplitude,…”
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Automated system for training and assessing reaching and grasping behaviors in rodents by Jordan, Gianna A, Vishwanath, Abhilasha, Holguin, Gabriel, Bartlett, Mitchell J, Tapia, Andrew K, Winter, Gabriel M, Sexauer, Morgan R, Stopera, Carolyn J, Falk, Torsten, Cowen, Stephen L

“…Reaching, grasping, and pulling behaviors are studied across species to investigate motor control and problem solving. String pulling is a distinct reaching…”
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Age Is Associated with Reduced Sharp-Wave Ripple Frequency and Altered Patterns of Neuronal Variability by Wiegand, Jean-Paul L, Gray, Daniel T, Schimanski, Lesley A, Lipa, Peter, Barnes, C A, Cowen, Stephen L

“…Spatial and episodic memory performance declines with age, and the neural basis for this decline is not well understood. Sharp-wave ripples are brief (∼70 ms)…”
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Firing rate modulation: A simple statistical view of memory trace reactivation by Battaglia, Francesco P., Sutherland, Gary R., Cowen, Stephen L., Mc Naughton, Bruce L., Harris, Kenneth D.

“…Memory trace reactivation in hippocampal ensembles during sleep has been suggested as a coordinating mechanism for consolidation of new memories. Here we…”
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Age‐associated changes in waking hippocampal sharp‐wave ripples by Cowen, Stephen L., Gray, Daniel T., Wiegand, Jean‐Paul L., Schimanski, Lesley A., Barnes, Carol A.

“…Hippocampal sharp‐wave ripples are brief high‐frequency (120–250 Hz) oscillatory events that support mnemonic processes during sleep and awake behavior…”
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Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats by Cowen, Stephen L., Phelps, Caroline E., Navratilova, Edita, McKinzie, David L., Okun, Alec, Husain, Omar, Gleason, Scott D., Witkin, Jeffrey M., Porreca, Frank

“…Cognitive flexibility, the ability to adapt behavior to changing outcomes, is critical to survival. The prefrontal cortex is a key site of cognitive control,…”
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Spontaneous alternation: A potential gateway to spatial working memory in Drosophila by Lewis, Sara A., Negelspach, David C., Kaladchibachi, Sevag, Cowen, Stephen L., Fernandez, Fabian

“…•Drosophila show alternating patterns of search in a classic rodent exploration paradigm, the Y-maze.•Drosophila have facilities for novelty seeking resembling…”
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