Search Results - "Cowell, Catherine F"

Progression from ductal carcinoma in situ to invasive breast cancer: Revisited by Cowell, Catherine F., Weigelt, Britta, Sakr, Rita A., Ng, Charlotte K.Y., Hicks, James, King, Tari A., Reis-Filho, Jorge S.

“…Ductal carcinoma in situ (DCIS) is an intraductal neoplastic proliferation of epithelial cells that is separated from the breast stroma by an intact layer of…”
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Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast by Piscuoglio, Salvatore, Ng, Charlotte K. Y., Geyer, Felipe C., Burke, Kathleen A., Cowell, Catherine F., Martelotto, Luciano G., Natrajan, Rachael, Popova, Tatiana, Maher, Christopher A., Lim, Raymond S., Bruijn, Ino de, Mariani, Odette, Norton, Larry, Vincent-Salomon, Anne, Weigelt, Britta, Reis-Filho, Jorge S.

“…Metaplastic breast cancer (MBC) is a rare special histologic type of triple-negative breast cancer, characterized by the presence of neoplastic cells showing…”
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Mitochondrial diacylglycerol initiates protein-kinase-D1-mediated ROS signaling by Cowell, Catherine F, Döppler, Heike, Yan, Irene K, Hausser, Angelika, Umezawa, Yoshio, Storz, Peter

“…Increases in reactive oxygen species (ROS) have been implicated in age-related diseases, including cancer. The serine/threonine kinase protein kinase D1 (PKD1)…”
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Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification by Ng, Charlotte K Y, Martelotto, Luciano G, Gauthier, Arnaud, Wen, Huei-Chi, Piscuoglio, Salvatore, Lim, Raymond S, Cowell, Catherine F, Wilkerson, Paul M, Wai, Patty, Rodrigues, Daniel N, Arnould, Laurent, Geyer, Felipe C, Bromberg, Silvio E, Lacroix-Triki, Magali, Penault-Llorca, Frederique, Giard, Sylvia, Sastre-Garau, Xavier, Natrajan, Rachael, Norton, Larry, Cottu, Paul H, Weigelt, Britta, Vincent-Salomon, Anne, Reis-Filho, Jorge S

“…HER2 is overexpressed and amplified in approximately 15% of invasive breast cancers, and is the molecular target and predictive marker of response to anti-HER2…”
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Metaplastic breast carcinoma: more than a special type by Weigelt, Britta, Eberle, Carey, Cowell, Catherine F., Ng, Charlotte K. Y., Reis-Filho, Jorge S.

“…Metaplastic breast carcinoma (MBC) accounts for 0.2–5% of invasive breast cancers. The majority of MBCs have a triple-negative phenotype, are highly…”
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PI3K Pathway Activation in High-Grade Ductal Carcinoma In Situ―Implications for Progression to Invasive Breast Carcinoma by SAKR, Rita A, WEIGELT, Britta, KING, Tari A, CHANDARLAPATY, Sarat, ANDRADE, Victor P, GUERINI-ROCCO, Elena, GIRI, Dilip, NG, Charlotte K. Y, COWELL, Catherine F, ROSEN, Neal, REIS, Jorge S

“…To assess the prevalence of phosphoinositide 3-kinase (PI3K) pathway alterations in pure high-grade ductal carcinoma in situ (DCIS) and DCIS associated with…”
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Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast by Piscuoglio, Salvatore, Ng, Charlotte K.Y., Martelotto, Luciano G., Eberle, Carey A., Cowell, Catherine F., Natrajan, Rachael, Bidard, François-Clement, De Mattos-Arruda, Leticia, Wilkerson, Paul M., Mariani, Odette, Vincent-Salomon, Anne, Weigelt, Britta, Reis-Filho, Jorge S.

“…Papillary carcinoma (PC) is a rare type of breast cancer, which comprises three histologic subtypes: encapsulated PC (EPC), solid PC (SPC) and invasive PC…”
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Loss of cell-cell contacts induces NF-κB via RhoA-mediated activation of protein kinase D1 by Cowell, Catherine F., Yan, Irene K., Eiseler, Tim, Leightner, Amanda C., Döppler, Heike, Storz, Peter

“…Cell–cell contacts mediated by cadherins are known to inhibit the small Rho‐GTPase RhoA. We here show that in epithelial cells the disruption of these…”
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Abstract A17: Loss of DEPTOR increases resistance to EGFR tyrosine kinase inhibitors by upregulating EGFR and MAPK signaling by Cowell, Catherine F., De Bruin, Elza C., Howell, Michael, Downward, Julian

“…Abstract Epidermal growth factor (EGFR) activating mutations occur in 10% to 40% of non-small cell lung cancer (NSCLC), and can be successfully targeted with…”
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Abstract LB-398: Identification of novel mechanisms of resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer by de Bruin, Elza C., Cowell, Catherine F., Howell, Michael, Varmus, Harold E., Politi, Katerina, Downward, Julian

“…Abstract Most lung adenocarcinoma patients with activating mutations in the Epidermal Growth Factor Receptor (EGFR) gene initially respond to EGFR tyrosine…”
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Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1 by Cowell, Catherine F, Yan, Irene K, Eiseler, Tim, Leightner, Amanda C, Döppler, Heike, Storz, Peter

“…Cell-cell contacts mediated by cadherins are known to inhibit the small Rho-GTPase RhoA. We here show that in epithelial cells the disruption of these…”
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